Michael Gill
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View article: The Role Of Cognitive Dissonance In Shaping Relationship Dynamics Among Teenagers And Adults
The Role Of Cognitive Dissonance In Shaping Relationship Dynamics Among Teenagers And Adults Open
Cognitive dissonance is an important aspect of influencing interactions between people, especially in the case of intimate relationships. It occurs when two or more conflicting beliefs, values, or behaviors cause psychological distress, pr…
View article: Whole genome sequencing study of identical twins discordant for psychosis
Whole genome sequencing study of identical twins discordant for psychosis Open
Monozygotic (MZ) twins are often thought to have identical genomes, but recent work has shown that early post-zygotic events can result in a spectrum of DNA variants that are different between MZ twins. Such variants may explain phenotypic…
View article: Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia Open
Genome-wide association studies (GWASs) are highly effective at identifying common risk variants for schizophrenia. Rare risk variants are also important contributors to schizophrenia etiology but, with the exception of large copy number v…
View article: Dna methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
Dna methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia Open
We performed a systematic analysis of blood DNA methylation profiles from 4,483 participants from seven independent cohorts identifying differentially methylated positions (DMPs) associated with psychosis, schizophrenia and treatment-resis…
View article: MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume
MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume Open
Background/Objective. Enlarged lateral ventricle (LV) volume and decreased volume in the corpus callosum (CC) are hallmarks of schizophrenia (SZ). We previously showed an inverse correlation between LV and CC volumes in SZ, with global fun…
View article: Best (overlooked) books 2012
Best (overlooked) books 2012 Open
Our contributors nominate the books from 2012 (or, in a few cases cases, late 2011) that didn't get the attention they deserved. Sylvia Lawson reviews the book 'A train in winter: a story of resistance, friendship and survival', by Carolin…
View article: Biotechnology of regulation of reproductive functions of Bos primigenius taurus
Biotechnology of regulation of reproductive functions of Bos primigenius taurus Open
Since cattle are biologically capable of giving birth to only one calf per year, they are considered a single-fruited animal species. One of the cardinal methods of solving the problem of accelerated reproduction of livestock is biotechnol…
View article: Mortality among persons entering hiv care compared with the general u.s. population: An observational study
Mortality among persons entering hiv care compared with the general u.s. population: An observational study Open
Background: Understanding advances in the care and treatment of adults with HIV as well as remaining gaps requires comparing differences in mortality between persons entering care for HIV and the general population. Objective: To assess th…
View article: Surgical Stress: The Muscle and Cognitive Demands of Robotic and Laparoscopic Surgery
Surgical Stress: The Muscle and Cognitive Demands of Robotic and Laparoscopic Surgery Open
Introduction: Surgeons are among the most at-risk professionals for work-related musculoskeletal decline and experience high mental demands. This study examined the electromyographic (EMG) and electroencephalographic (EEG) activities of su…
View article: Ultrarare Missense Variants Implicated in Utah Pedigrees Multiply Affected With Schizophrenia
Ultrarare Missense Variants Implicated in Utah Pedigrees Multiply Affected With Schizophrenia Open
We have identified genes that are likely to increase schizophrenia risk in 3 of the 6 pedigrees examined, the strongest evidence being for a gene involved in calcium homeostasis. Further work is required to examine other classes of variant…
View article: Identity-by-descent analysis of a large Tourette’s syndrome pedigree from Costa Rica implicates genes involved in neuronal development and signal transduction
Identity-by-descent analysis of a large Tourette’s syndrome pedigree from Costa Rica implicates genes involved in neuronal development and signal transduction Open
Tourette Syndrome (TS) is a heritable, early-onset neuropsychiatric disorder that typically begins in early childhood. Identifying rare genetic variants that make a significant contribution to risk in affected families may provide importan…
View article: Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families
Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families Open
Multiplex families have higher recurrence risk of schizophrenia compared to the families of sporadic cases, but the source of this increased recurrence risk is unknown. We used schizophrenia genome-wide association study data ( N = 156,509…
View article: A novel group of genes that cause endocrine resistance in breast cancer identified by dynamic gene expression analysis
A novel group of genes that cause endocrine resistance in breast cancer identified by dynamic gene expression analysis Open
Breast cancer (BC) is the most common type of cancer diagnosed in women. Among female cancer deaths, BC is the second leading cause of death worldwide. For estrogen receptor-positive (ER-positive) breast cancers, endocrine therapy is an ef…
View article: A Novel Group of Genes that Causes Endocrine Resistance in Breast Cancer Identified by Dynamic Gene Expression Analysis
A Novel Group of Genes that Causes Endocrine Resistance in Breast Cancer Identified by Dynamic Gene Expression Analysis Open
Breast cancer (BC) is the most common type of cancer and the second leading cancer-related cause of death in women worldwide. Endocrine therapy is an effective therapeutic approach for estrogen receptor (ER)-positive breast cancer; however…
View article: The Genetic Architecture of Depression in Individuals of East Asian Ancestry
The Genetic Architecture of Depression in Individuals of East Asian Ancestry Open
These results support caution against generalizing findings about depression risk factors across populations and highlight the need to increase the ancestral and geographic diversity of samples with consistent phenotyping.
View article: A <scp>meta‐analysis</scp> of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the <scp>ENIGMA Consortium</scp>
A <span>meta‐analysis</span> of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the <span>ENIGMA Consortium</span> Open
Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta‐analysis, we employed the h…
View article: Characterisation of age and polarity at onset in bipolar disorder
Characterisation of age and polarity at onset in bipolar disorder Open
Background Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. Aims To exa…
View article: Carepath for overcoming psychosis early (COPE): first 5 years of clinical operation and prospective research in the Cavan–Monaghan early intervention service
Carepath for overcoming psychosis early (COPE): first 5 years of clinical operation and prospective research in the Cavan–Monaghan early intervention service Open
Objectives: As Ireland confronts the many challenges of broadening the introduction of early intervention services (EIS) for first episode psychosis (FEP) as national policy, this article describes Carepath for Overcoming Psychosis Early (…
View article: Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics
Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics Open
Broad-based cognitive deficits are an enduring and disabling symptom for many patients with severe mental illness, and these impairments are inadequately addressed by current medications. While novel drug targets for schizophrenia and depr…