Michael Glatza
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Culturing human iPSC-derived neural progenitor cells on nanowire arrays: mapping the impact of nanowire length and array pitch on proliferation, viability, and membrane deformation Open
We tested the growth of human iPSC-derived NPCs on nanowire arrays across a wide range of array characteristics. The proliferation, viability, and interaction with the nanowire arrays were mapped depending on the array pitch and nanowire l…
Modeling Parkinson’s disease in midbrain-like organoids Open
Modeling Parkinson’s disease (PD) using advanced experimental in vitro models is a powerful tool to study disease mechanisms and to elucidate unexplored aspects of this neurodegenerative disorder. Here, we demonstrate that three-dimensiona…
Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease Open
Induced pluripotent stem cells (iPSCs) have recapitulated several aspects of Parkinson's disease (PD), but most iPSCs are derived from familial cases, which account for only about 15% of patients. Thus, while the emphasis has justifiably b…
Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors Open
Significance Understanding of myelin diseases and development of new treatment options are at least partly hampered by the limited availability of human oligodendrocytes. Induced pluripotent stem cells (iPSC) may be an ideal tool to circum…