Michael Glendinning
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View article: Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke
Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke Open
The integrity of adherens and tight junctions is critical for blood-brain barrier (BBB) function in the healthy brain. Disassembly of cell junctions due to degradation of adherens and tight junction-associated proteins leads to acute BBB d…
View article: miR-126 modulates neural progenitor cell development
miR-126 modulates neural progenitor cell development Open
Summary Noncoding microRNAs (miRNAs) play important roles in controlling signaling pathways by targeting multiple genes and altering their expression levels. MiR-126 is a known endothelial-specific miRNA that regulates vascular integrity a…
View article: Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke
Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke Open
SUMMARY Adherens (AJ) and tight junction (TJ) integrity is critical for blood-brain barrier (BBB) function in the healthy brain. Junction disassembly due to degradation of AJ and TJ proteins leads to acute BBB dysfunction after ischemic st…
View article: Single-cell RNA-sequencing implicates venous endothelial cells as a source of VEGF-A-mediated neo-angiogenesis in neuroinflammation
Single-cell RNA-sequencing implicates venous endothelial cells as a source of VEGF-A-mediated neo-angiogenesis in neuroinflammation Open
Histopathological studies of multiple sclerosis (MS), a demyelinating disease of the central nervous system (CNS), and its animal model, experimental autoimmune encephalomyelitis (EAE), have found newly formed leaky vessels in demyelinated…
View article: COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital
COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital Open
Many patients with SARS-CoV-2 infection develop neurological signs and symptoms; although, to date, little evidence exists that primary infection of the brain is a significant contributing factor. We present the clinical, neuropathological…
View article: COVID-19 Neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital
COVID-19 Neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital Open
Many patients with SARS-CoV-2 infection develop neurological signs and symptoms, though, to date, little evidence exists that primary infection of the brain is a significant contributing factor. We present the clinical, neuropathological, …
View article: miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta
miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta Open