Michael Gombert
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View article: Supplementary Figure Legends, Table Legends, Figures S1 - S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Figure Legends, Table Legends, Figures S1 - S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
The PDF includes legends for Supplementary Tables S1 - S5 as well as legends for Supplementary Figures S1 - S3. Supplementary Figure S1 indicates pathogens detected in mice held in the SPF and conventional animal facility. Supplementary Fi…
View article: Supplementary Table S1 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S1 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Health monitoring report of PAx5+/- held in the SPF and conventional animal facility.
View article: Supplementary Table S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Pax5 target genes differentially express in p-BALL bearing Pax5+/- mice according to Delogu A. et al 2006, Schebesta A. et al 2007, and Revilla-i-Domingo R. et al 2012.
View article: Data from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Data from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Earlier in the past century, infections were regarded as the most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). However, there is a lack of relevant biologic evidence supporting this hypothesis. We prese…
View article: Supplementary Table S1 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S1 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Health monitoring report of PAx5+/- held in the SPF and conventional animal facility.
View article: Supplementary Table S2 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S2 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Differentially expressed genes in bone marrow tumors from Pax5+/- mice compared to wild-type B220+ bone marrow B cells.
View article: Supplementary Table S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Pax5 target genes differentially express in p-BALL bearing Pax5+/- mice according to Delogu A. et al 2006, Schebesta A. et al 2007, and Revilla-i-Domingo R. et al 2012.
View article: Data from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Data from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Earlier in the past century, infections were regarded as the most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). However, there is a lack of relevant biologic evidence supporting this hypothesis. We prese…
View article: Supplementary Table S5 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S5 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
SNVs detected by whole exam sequencing in the three index Pax5+/- pB-ALL.
View article: Supplementary Table S5 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S5 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
SNVs detected by whole exam sequencing in the three index Pax5+/- pB-ALL.
View article: Supplementary Table S4 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S4 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Total numbers and percentage of hematopoietic subsets in young Pax5+/- and wild type mice.
View article: Supplementary Figure Legends, Table Legends, Figures S1 - S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Figure Legends, Table Legends, Figures S1 - S3 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
The PDF includes legends for Supplementary Tables S1 - S5 as well as legends for Supplementary Figures S1 - S3. Supplementary Figure S1 indicates pathogens detected in mice held in the SPF and conventional animal facility. Supplementary Fi…
View article: Supplementary Table S4 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S4 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Total numbers and percentage of hematopoietic subsets in young Pax5+/- and wild type mice.
View article: Supplementary Table S2 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility
Supplementary Table S2 from Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of <i>Pax5</i>-Inherited Susceptibility Open
Differentially expressed genes in bone marrow tumors from Pax5+/- mice compared to wild-type B220+ bone marrow B cells.
View article: Table S4 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL
Table S4 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL Open
Differentially expressed genes in bone marrow tumors from Sca1-BCR-ABLp190+Pax5+/- mice compared to wild-type B220+ bone marrow B cells. (17032 genes-probesets with FDR = 0.05)
View article: Supplementary Table 4 from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases
Supplementary Table 4 from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases Open
Supplementary Table 4: Differentially expressed genes in bone marrow proB and preB cells from ETV6-RUNX1 mice compared to wild-type bone marrow proB and preB cells. (12423 genes-probesets with FDR = 0.1).
View article: Supplementary Tables 1-3, 5-9,Supplementary Figures 1-5 from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases
Supplementary Tables 1-3, 5-9,Supplementary Figures 1-5 from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases Open
Contents: Supplementary Table 1: Characteristics of the pediatric patients enrolled in whole-genome- and whole-exome-sequencing. Supplementary Table 2: Conventional Facility Health Monitoring Report. Supplementary Table 3: Percentage of he…
View article: Data from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases
Data from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases Open
ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. As few ETV6-RUNX1 carriers develop precursor B-cell acute lymphocytic leukemia (pB-ALL), the underlying genetic basis for development of full-blown leukemia remai…
View article: Table S2 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL
Table S2 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL Open
Differentially expressed genes in bone marrow tumors from Sca1-BCR-ABLp190 mice compared to wild-type B220+ bone marrow B cells. (3692 genes-probesets with FDR = 0.05)
View article: Supplementary Figures S1-S12 and Supplementary Tables S1 and S3 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL
Supplementary Figures S1-S12 and Supplementary Tables S1 and S3 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL Open
Supplementary Figure 1: Mouse generation and GSEA enrichment analysis of Sca1-BCR-ABLp190 mice. Supplementary Figure 2: Time course of the percentage of B220+ cells in PB of Sca1-BCR-ABLp190 and Sca1-BCR-ABLp190+Pax5+/- mice. Supplementary…
View article: Supplementary Table 4 from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases
Supplementary Table 4 from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases Open
Supplementary Table 4: Differentially expressed genes in bone marrow proB and preB cells from ETV6-RUNX1 mice compared to wild-type bone marrow proB and preB cells. (12423 genes-probesets with FDR = 0.1).
View article: Supplementary Information from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL
Supplementary Information from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL Open
Supplementary Figures and Table legends as well as supplementary methods
View article: Data from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases
Data from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases Open
ETV6-RUNX1 is associated with the most common subtype of childhood leukemia. As few ETV6-RUNX1 carriers develop precursor B-cell acute lymphocytic leukemia (pB-ALL), the underlying genetic basis for development of full-blown leukemia remai…
View article: Data from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL
Data from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL Open
Preleukemic clones carrying BCR-ABLp190 oncogenic lesions are found in neonatal cord blood, where the majority of preleukemic carriers do not convert into precursor B-cell acute lymphoblastic leukemia (pB-ALL). However, the critical questi…
View article: Supplementary Figures S1-S12 and Supplementary Tables S1 and S3 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL
Supplementary Figures S1-S12 and Supplementary Tables S1 and S3 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL Open
Supplementary Figure 1: Mouse generation and GSEA enrichment analysis of Sca1-BCR-ABLp190 mice. Supplementary Figure 2: Time course of the percentage of B220+ cells in PB of Sca1-BCR-ABLp190 and Sca1-BCR-ABLp190+Pax5+/- mice. Supplementary…
View article: Supplementary Tables 1-3, 5-9,Supplementary Figures 1-5 from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases
Supplementary Tables 1-3, 5-9,Supplementary Figures 1-5 from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases Open
Contents: Supplementary Table 1: Characteristics of the pediatric patients enrolled in whole-genome- and whole-exome-sequencing. Supplementary Table 2: Conventional Facility Health Monitoring Report. Supplementary Table 3: Percentage of he…
View article: Supplementary Information from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL
Supplementary Information from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL Open
Supplementary Figures and Table legends as well as supplementary methods
View article: Table S4 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL
Table S4 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL Open
Differentially expressed genes in bone marrow tumors from Sca1-BCR-ABLp190+Pax5+/- mice compared to wild-type B220+ bone marrow B cells. (17032 genes-probesets with FDR = 0.05)
View article: Table S2 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL
Table S2 from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL Open
Differentially expressed genes in bone marrow tumors from Sca1-BCR-ABLp190 mice compared to wild-type B220+ bone marrow B cells. (3692 genes-probesets with FDR = 0.05)
View article: Data from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL
Data from Loss of Pax5 Exploits Sca1-BCR-ABL<sup>p190</sup> Susceptibility to Confer the Metabolic Shift Essential for pB-ALL Open
Preleukemic clones carrying BCR-ABLp190 oncogenic lesions are found in neonatal cord blood, where the majority of preleukemic carriers do not convert into precursor B-cell acute lymphoblastic leukemia (pB-ALL). However, the critical questi…