Michael Grau
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View article: Quality of life assessment in diffuse large B-cell lymphoma (DLBCL) in REFLECT: a prospective, non-interventional, multicenter, German study, assessing Sandoz rituximab in combination with CHOP
Quality of life assessment in diffuse large B-cell lymphoma (DLBCL) in REFLECT: a prospective, non-interventional, multicenter, German study, assessing Sandoz rituximab in combination with CHOP Open
Health-related quality of life (HRQoL) data are important indicators of health status in patients with lymphoma. The objective of this analysis was to assess the impact of treatment with Sandoz rituximab plus cyclophosphamide, doxorubicin,…
View article: Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination
Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination Open
The protease MALT1 promotes lymphocyte activation and lymphomagenesis by cleaving a limited set of cellular substrates, most of which control gene expression. Here, we identified the integrin-binding scaffold protein Tensin-3 as a MALT1 su…
View article: Transcriptional reprogramming by mutated IRF4 in lymphoma
Transcriptional reprogramming by mutated IRF4 in lymphoma Open
Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements (CE) and the interactio…
View article: Oncogene-induced MALT1 protease activity drives posttranscriptional gene expression in malignant lymphomas
Oncogene-induced MALT1 protease activity drives posttranscriptional gene expression in malignant lymphomas Open
Constitutive mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) activity drives survival of malignant lymphomas addicted to chronic B-cell receptor signaling, oncogenic CARD11, or the API2-MALT1 (also BIRC3::MALT1) …
View article: P1227: COMPREHENSIVE MOLECULAR SUBTYPING OF DIFFUSE LARGE B-CELL LYMPHOMA CELL LINES AND ASSOCIATION WITH TAFASITAMAB ACTIVITY
P1227: COMPREHENSIVE MOLECULAR SUBTYPING OF DIFFUSE LARGE B-CELL LYMPHOMA CELL LINES AND ASSOCIATION WITH TAFASITAMAB ACTIVITY Open
Topic: 20. Lymphoma Biology & Translational Research Background: Tafasitamab (tafa), an anti-CD19 immunotherapy that enhances antibody dependent cellular cytotoxicity (ADCC) and phagocytosis, achieved a 57.5% objective response rate in com…
View article: Activity of tafasitamab in combination with rituximab in subtypes of aggressive lymphoma
Activity of tafasitamab in combination with rituximab in subtypes of aggressive lymphoma Open
Background Despite recent advances in the treatment of aggressive lymphomas, a significant fraction of patients still succumbs to their disease. Thus, novel therapies are urgently needed. As the anti-CD20 antibody rituximab and the CD19-ta…
View article: Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms
Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms Open
Knowledge on the pathogenesis of FL is mainly based on data derived from advanced/systemic stages of FL (sFL) and only small cohorts of localized FL (lFL) have been characterized intensively so far. Comprehensive analysis with profiling of…
View article: Supplementary Movie 1 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation
Supplementary Movie 1 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation Open
Supplementary Movie S1. Follicular motility of Emu-Tcl1 leukemia cells. The Movie complements Figure 4J.
View article: Data from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation
Data from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation Open
In human chronic lymphocytic leukemia (CLL) pathogenesis, B-cell antigen receptor signaling seems important for leukemia B-cell ontogeny, whereas the microenvironment influences B-cell activation, tumor cell lodging, and provision of antig…
View article: Supplementary Methods, Figures S1 - S9 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation
Supplementary Methods, Figures S1 - S9 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation Open
Figure S1. Gating strategy to characterize and quantitate CD19+CD5+ leukemia Emu-Tcl1 cell frequencies and homeostatic chemokine receptor expression on splenic, LN, PB, and BM derived CD19+CD5+ gated Emu-Tcl1 tumor cells. This Figure compl…
View article: Supplementary Movie 2 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation
Supplementary Movie 2 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation Open
Supplemental Movie S2. Follicular motility of B cells. The Movie complements Figure 4J.
View article: Supplementary Movie 1 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation
Supplementary Movie 1 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation Open
Supplementary Movie S1. Follicular motility of Emu-Tcl1 leukemia cells. The Movie complements Figure 4J.
View article: Supplementary Methods, Figures S1 - S9 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation
Supplementary Methods, Figures S1 - S9 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation Open
Figure S1. Gating strategy to characterize and quantitate CD19+CD5+ leukemia Emu-Tcl1 cell frequencies and homeostatic chemokine receptor expression on splenic, LN, PB, and BM derived CD19+CD5+ gated Emu-Tcl1 tumor cells. This Figure compl…
View article: Data from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation
Data from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation Open
In human chronic lymphocytic leukemia (CLL) pathogenesis, B-cell antigen receptor signaling seems important for leukemia B-cell ontogeny, whereas the microenvironment influences B-cell activation, tumor cell lodging, and provision of antig…
View article: Supplementary Movie 2 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation
Supplementary Movie 2 from Access to Follicular Dendritic Cells Is a Pivotal Step in Murine Chronic Lymphocytic Leukemia B-cell Activation and Proliferation Open
Supplemental Movie S2. Follicular motility of B cells. The Movie complements Figure 4J.
View article: Supplementary Figure S5 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia
Supplementary Figure S5 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia Open
Eμ-Tcl1 leukemia-associated splenic neutrophils exhibit a unique gene expression profile.
View article: Supplementary Data Fig. S5 from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways
Supplementary Data Fig. S5 from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways Open
Vascular permeability and leukocyte transmigration
View article: Supplementary Figure S4 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia
Supplementary Figure S4 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia Open
Neutrophil depletion does not affect the pro-inflammatory cytokine milieu in Eμ-Tcl1 leukemia B cells.
View article: Supplementary Data Text from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways
Supplementary Data Text from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways Open
Supplementary Material+Methods, Legends, References
View article: Supplementary Data Fig. S1 from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways
Supplementary Data Fig. S1 from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways Open
PNAd detection on DLBCL
View article: Supplementary Data Fig. S2 from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways
Supplementary Data Fig. S2 from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways Open
Lack of inflammatory gene signatures
View article: Supplementary Figure S1 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia
Supplementary Figure S1 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia Open
Top pathways identified by gene set enrichment analysis.
View article: Supplementary Figure S5 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia
Supplementary Figure S5 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia Open
Eμ-Tcl1 leukemia-associated splenic neutrophils exhibit a unique gene expression profile.
View article: Supplementary Data Text from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways
Supplementary Data Text from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways Open
Supplementary Material+Methods, Legends, References
View article: Supplementary Figure S1 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia
Supplementary Figure S1 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia Open
Top pathways identified by gene set enrichment analysis.
View article: Supplementary Data Fig. S7 from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways
Supplementary Data Fig. S7 from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways Open
Solid tumors respond to VEGFR-2 inhibition
View article: Supplementary Table S1 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia
Supplementary Table S1 from Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia Open
Tumor-induced down- and upregulations of genes in the stroma.
View article: Data from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways
Data from Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways Open
Tumor-induced remodeling of the microenvironment relies on the formation of blood vessels, which go beyond the regulation of metabolism, shaping a maladapted survival niche for tumor cells. In high-grade B-cell lymphoma, angiogenesis corre…