Michael G. Bartlett
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View article: Mechanistic insights into P-glycoprotein-driven transport of anti-cancer PARP inhibitors
Mechanistic insights into P-glycoprotein-driven transport of anti-cancer PARP inhibitors Open
P-glycoprotein (Pgp), a membrane-bound transporter protein, plays significant roles in the development of multidrug resistance (MDR) and in drug disposition. Understanding the interactions between Pgp and its substrates is therefore crucia…
View article: Elucidating the Complex Structural and Molecular Mechanisms Driving P-Glycoprotein-Mediated Transport of Cardiac Glycosides
Elucidating the Complex Structural and Molecular Mechanisms Driving P-Glycoprotein-Mediated Transport of Cardiac Glycosides Open
P-glycoprotein (Pgp) plays a significant role in the disposition of cardiac glycoside (CG) drugs across the cell membrane. The relatively narrow therapeutic indices of these drugs, coupled with the co-administration of drugs that inhibit P…
View article: LC-MS analysis of RNA through hydrogen bonding of alkylamines
LC-MS analysis of RNA through hydrogen bonding of alkylamines Open
Nucleic acid oligonucleotides represent a promising therapy for treating disease. Production of these biopolymers happens synthetically which can produce impurities concomitant with the desired product. The use of liquid chromatography cou…
View article: Rapid Microwave Sintering and the Effect on Microstructural Development and Ionic Conductivity in Lithium Aluminum Germanium Phosphate
Rapid Microwave Sintering and the Effect on Microstructural Development and Ionic Conductivity in Lithium Aluminum Germanium Phosphate Open
Solid‐state electrolytes represent a significant advancement over liquid electrolytes in terms of safety, reliability, and energy density, but maximizing ionic conductivity requires energy‐inefficient high‐temperature thermal processing th…
View article: Identification of blood lipid markers of docetaxel treatment in prostate cancer patients
Identification of blood lipid markers of docetaxel treatment in prostate cancer patients Open
Docetaxel is commonly used for treatment of castration-resistant prostate cancer. Unfortunately, many prostate cancer patients develop resistance to docetaxel. Clinical markers less invasive than biopsies, such as blood samples, would be i…
View article: Ursolic Acid Conjugates: A New Frontier in Anticancer Drug Development
Ursolic Acid Conjugates: A New Frontier in Anticancer Drug Development Open
New Ursolic Acid (UA) conjugates were synthesized using optimized synthetic protocols through the molecular hybridization approach at C‐3 and C‐28. This resulted in the targeted molecules being produced in good yields. Some of the synthesi…
View article: Mobile Phase Aging and Its Impact on Electrospray Ionization of Oligonucleotides
Mobile Phase Aging and Its Impact on Electrospray Ionization of Oligonucleotides Open
The implementation of fluoroalcohol/alkylamine mobile phase systems in oligonucleotide LC-MS provides a good balance between chromatographic separations and MS sensitivity. Since its introduction, several parameters including mobile phase …
View article: Drug-Induced Conformational Dynamics of P-Glycoprotein Underlies the Transport of Camptothecin Analogs
Drug-Induced Conformational Dynamics of P-Glycoprotein Underlies the Transport of Camptothecin Analogs Open
P-glycoprotein (Pgp) plays a pivotal role in drug bioavailability and multi-drug resistance development. Understanding the protein’s activity and designing effective drugs require insight into the mechanisms underlying Pgp-mediated transpo…
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View article: Characterization of mRNA therapeutics
Characterization of mRNA therapeutics Open
Therapeutic messenger RNAs (mRNAs) have emerged as powerful tools in the treatment of complex diseases, especially for conditions that lack efficacious treatment. The successful application of this modality can be attributed to its ability…
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View article: Prodrug Strategies for the Development of β-<scp>l</scp>-5-((<i>E</i>)-2-Bromovinyl)-1-((2<i>S</i>,4<i>S</i>)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (<scp>l</scp>-BHDU) against Varicella Zoster Virus (VZV)
Prodrug Strategies for the Development of β-<span>l</span>-5-((<i>E</i>)-2-Bromovinyl)-1-((2<i>S</i>,4<i>S</i>)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (<span>l</span>-BHDU) against Varicella Zoster Virus (VZV) Open
Varicella zoster virus (VZV) establishes lifelong infection after primary disease and can reactivate. Several drugs are approved to treat VZV diseases, but new antivirals with greater potency are needed. Previously, we identified β-l-5-((E…
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View article: Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer
Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer Open
Androgen deprivation therapy has led to elevated cases of androgen receptor (AR) pathway–independent prostate cancer with dysregulated fatty acid metabolism. However, it is unclear how prostate cancer cells sustain dysregulated fatty acid …
View article: Supplementary Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer
Supplementary Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer Open
Table S1. ChIP-qPCR primer sequences 5 kb upstream of ACSL4 Table S2. Primer sequences used for shRNAs, RT-PCR and ACSL4 primers 9 Figure S1. ACSLs expression levels in prostate cancer cell lines. Figure S2, related to Figure 3. Identifica…
View article: Supplementary Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer
Supplementary Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer Open
Table S1. ChIP-qPCR primer sequences 5 kb upstream of ACSL4 Table S2. Primer sequences used for shRNAs, RT-PCR and ACSL4 primers 9 Figure S1. ACSLs expression levels in prostate cancer cell lines. Figure S2, related to Figure 3. Identifica…
View article: Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer
Data from Long-Chain Acyl-CoA Synthetase 4–Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway–Independent Prostate Cancer Open
Androgen deprivation therapy has led to elevated cases of androgen receptor (AR) pathway–independent prostate cancer with dysregulated fatty acid metabolism. However, it is unclear how prostate cancer cells sustain dysregulated fatty acid …
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No abstract is available for this article.
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No abstract is available for this article.
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No abstract is available for this article.
View article: Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice
Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice Open
The brain of WT mice, in particular WT male mice, might be especially susceptible to the effects of chronic SHS exposure. In WT males, independent pathways involving ascorbate, flavin adenine dinucleotide, or palmitoleic acid might contrib…
View article: The patient perspective of alpha-1 antitrypsin deficiency: disease burden and unmet needs
The patient perspective of alpha-1 antitrypsin deficiency: disease burden and unmet needs Open
Three people with alpha-1 antitrypsin deficiency (AATD) share their experiences of living with this rare, genetic condition. They reflect on living with AATD and its impact on their lives including inequality of access to treatment across …