Michael Groessl
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View article: Characterization of Steroid Metabolic Pathways in Established Human and Mouse Cell Models
Characterization of Steroid Metabolic Pathways in Established Human and Mouse Cell Models Open
Immortalized adrenal, placental and gonadal cell models are often termed steroidogenic based on steroid hormone production and steroidogenic enzymes. Profiling of ‘classic’ steroid metabolites is common; however, downstream untargeted meta…
View article: Landscape of Steroid Dynamics in Pregnancy: Insights From the Maternal-Placental-Fetal Unit and Placental Models
Landscape of Steroid Dynamics in Pregnancy: Insights From the Maternal-Placental-Fetal Unit and Placental Models Open
Recent advances in analytical methods have revolutionized our understanding of steroid biochemistry. The emergence of novel steroids such as 11-oxy androgens and 11-oxy progesterones has necessitated a reevaluation of steroid biosynthesis …
View article: Safety and efficacy of once-daily dexfadrostat phosphate in patients with primary aldosteronism: a randomised, parallel group, multicentre, phase 2 trial
Safety and efficacy of once-daily dexfadrostat phosphate in patients with primary aldosteronism: a randomised, parallel group, multicentre, phase 2 trial Open
View article: Structural and clinical characterization of CYP11B2 inhibition by dexfadrostat phosphate
Structural and clinical characterization of CYP11B2 inhibition by dexfadrostat phosphate Open
Aldosterone synthase (CYP11B2) represents a promising drug target because its genetic dysregulation is causally associated with cardiovascular disease, its autonomous activity leads to primary aldosteronism, and its deficiency leads to sal…
View article: THU207 11-oxygenated Androgens Are Strongly Associated With Treatment Quality In Children With Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
THU207 11-oxygenated Androgens Are Strongly Associated With Treatment Quality In Children With Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency Open
Disclosure: O. Abawi: None. T. Du Toit: None. G. Sommer: None. C.D. Vögel: None. M. Groessl: None. U. Halbsguth: None. S.E. Hannema: None. C. de Bruin: None. E. Charmandari: None. E.L. van den Akker: None. C.E. Flueck: None. Introduction: …
View article: FRI382 High Androgen And Progesterone Metabolite Concentrations In Naturally Matured Follicles Are Concurrent With High Serum Anti-Müllerian Hormone Concentrations
FRI382 High Androgen And Progesterone Metabolite Concentrations In Naturally Matured Follicles Are Concurrent With High Serum Anti-Müllerian Hormone Concentrations Open
Disclosure: T. Du Toit: None. M. Von Wolff: None. A.C. Swart: None. M. Groessl: None. C.E. Flueck: None. Infertility in women is routinely evaluated with the assessment of circulating steroid levels. Profiling steroid levels in follicular …
View article: THU208 Predicting Treatment Quality Assessment Of Children With Congenital Adrenal Hyperplasia Using 24h Urine Metabolomics Profiling And A Machine Learning-assisted Approach
THU208 Predicting Treatment Quality Assessment Of Children With Congenital Adrenal Hyperplasia Using 24h Urine Metabolomics Profiling And A Machine Learning-assisted Approach Open
Disclosure: O. Abawi: None. G. Sommer: None. M. Groessl: None. U. Halbsguth: None. S.E. Hannema: None. C. de Bruin: None. E. Charmandari: None. E.L. van den Akker: None. A.B. Leichtle: None. C.E. Flueck: None. Introduction: Current treatme…
View article: The serum steroid signature of PCOS hints at the involvement of novel pathways for excess androgen biosynthesis
The serum steroid signature of PCOS hints at the involvement of novel pathways for excess androgen biosynthesis Open
Novel alternative pathways contribute to the androgen production in healthy and PCOS women. Hyperandrogenism in PCOS is characterized by an overall increase of serum androgens in the classic, backdoor and C11-oxy pathways. While monogeneti…
View article: The Serum Steroid Signature of Pcos Hints at the Involvement of Novel Pathways for Excess Androgen Biosynthesis
The Serum Steroid Signature of Pcos Hints at the Involvement of Novel Pathways for Excess Androgen Biosynthesis Open
View article: The Androgen Metabolome of Preterm Infants Reflects Fetal Adrenal Gland Involution
The Androgen Metabolome of Preterm Infants Reflects Fetal Adrenal Gland Involution Open
Context The human adrenal cortex changes with fetal-neonatal transition from the fetal to the adult organ, accompanied by changes in the steroid metabolome. Objective As it is unclear how the observed developmental changes differ between p…
View article: Electrocautery smoke exposure and efficacy of smoke evacuation systems in minimally invasive and open surgery: a prospective randomized study
Electrocautery smoke exposure and efficacy of smoke evacuation systems in minimally invasive and open surgery: a prospective randomized study Open
View article: Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry
Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry Open
We developed and validated a liquid chromatography high-resolution mass spectrometry method for the absolute quantification of 51 steroids for clinical analysis of human serum and, for the first time, peritoneal fluid. Data acquisition was…
View article: Supplementary Material
Supplementary Material Open
The androgen metabolome of preterm infants reflects fetal adrenal gland involution
View article: Supplementary Material
Supplementary Material Open
The androgen metabolome of preterm infants reflects fetal adrenal gland involution
View article: Effects of Aerobic Exercise on Systemic Insulin Degludec Concentrations in People with Type 1 Diabetes
Effects of Aerobic Exercise on Systemic Insulin Degludec Concentrations in People with Type 1 Diabetes Open
Background: There is conflicting evidence on the effect of exercise on systemic insulin concentrations in adults with type 1 diabetes. Methods: This prospective single-arm study examined the effect of exercise on systemic insulin degludec …
View article: Sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults
Sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults Open
Objective Diagnostic ratios calculated from urinary steroid hormone metabolites are used as a measure for the relative activity of steroidogenic enzymes or pathways in the clinical investigation of steroid metabolism disorders. However, po…
View article: Correction: Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis
Correction: Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis Open
[This corrects the article DOI: 10.1371/journal.pone.0214549.].
View article: Salivary cortisol in healthy dogs: a randomized cross-over study to evaluate different saliva stimulation methods and their effects on saliva volume and cortisol concentration
Salivary cortisol in healthy dogs: a randomized cross-over study to evaluate different saliva stimulation methods and their effects on saliva volume and cortisol concentration Open
Background Salivary cortisol collected at home is a useful test to diagnose and monitor Cushing’s syndrome in humans. The main problem in dogs is to retrieve a sufficient amount of saliva. The aim of this study was to evaluate different sa…
View article: Steroid hormone bioavailability is controlled by the lymphatic system
Steroid hormone bioavailability is controlled by the lymphatic system Open
The steroid hormone progesterone accounts for immune tolerance in pregnancy. Enhanced progesterone metabolism to 6α-OH-pregnanolone occurs in complicated pregnancies such as in preeclampsia with preterm delivery or intrauterine growth rest…
View article: Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells
Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells Open
Steroid hormones play a crucial role in supporting a successful pregnancy and ensuring proper fetal development. The placenta is one of the principal tissues in steroid production and metabolism, expressing a vast range of steroidogenic en…
View article: Rapid quantification of insulin degludec by immunopurification combined with liquid chromatography high-resolution mass spectrometry
Rapid quantification of insulin degludec by immunopurification combined with liquid chromatography high-resolution mass spectrometry Open
Insulin degludec is an ultra-long-acting insulin analogue that is increasingly being used in diabetes due to its favourable efficacy and safety profile. Thus, there is an increasing demand for a reliable and specific analytical method to q…
View article: Premature Adrenarche in Girls Characterized By Enhanced 17,20-Lyase and 17β-Hydroxysteroid Dehydrogenase Activities
Premature Adrenarche in Girls Characterized By Enhanced 17,20-Lyase and 17β-Hydroxysteroid Dehydrogenase Activities Open
Context Girls with premature adrenarche (PA) may have a higher risk of developing polycystic ovary syndrome (PCOS) and metabolic syndrome. The biological purpose of adrenarche is unknown and the role of novel biosynthetic pathways remains …
View article: Characterization of Two Novel Variants of the Steroidogenic Acute Regulatory Protein Identified in a Girl with Classic Lipoid Congenital Adrenal Hyperplasia
Characterization of Two Novel Variants of the Steroidogenic Acute Regulatory Protein Identified in a Girl with Classic Lipoid Congenital Adrenal Hyperplasia Open
Congenital adrenal hyperplasia (CAH) consists of several autosomal recessive disorders that inhibit steroid biosynthesis. We describe a case report diagnosed with adrenal insufficiency due to low adrenal steroids and adrenocorticotropic ho…
View article: SUN-073 Urine Steroid Profile of Girls with Premature Adrenarche
SUN-073 Urine Steroid Profile of Girls with Premature Adrenarche Open
Background: Adrenarche describes the development of the human adrenal cortex when the zona reticularis increases the synthesis of C19 steroids (DHEA/-S). Girls with premature adrenarche have a higher risk to develop adverse outcomes includ…
View article: Quantitative Fragmentation Model for Bottom-Up Shotgun Lipidomics
Quantitative Fragmentation Model for Bottom-Up Shotgun Lipidomics Open
Quantitative bottom-up shotgun lipidomics relies on molecular species-specific "signature" fragments consistently detectable in tandem mass spectra of analytes and standards. Molecular species of glycerophospholipids are typically quantifi…
View article: Collision cross sections of negative cluster ions of phosphoric acid in N2 determined by drift tube ion mobility and their use in travelling wave ion mobility
Collision cross sections of negative cluster ions of phosphoric acid in N2 determined by drift tube ion mobility and their use in travelling wave ion mobility Open
View article: Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis
Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis Open
This study gives unprecedented new insights into sex- and age-specificity of the human adult steroid metabolome and provides further information on the day/night variation of urinary steroid hormone excretion. The population-based referenc…
View article: Recommendations for reporting ion mobility Mass Spectrometry measurements
Recommendations for reporting ion mobility Mass Spectrometry measurements Open
Here we present a guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties of mobility …
View article: Urinary Sex Steroid and Glucocorticoid Hormones Are Associated With Muscle Mass and Strength in Healthy Adults
Urinary Sex Steroid and Glucocorticoid Hormones Are Associated With Muscle Mass and Strength in Healthy Adults Open
Sex steroids and glucocorticoids are strongly positively associated with skeletal muscle mass and strength in the upper limbs. The associations with muscle strength appear to be independent of muscle mass. Steroid hormones exert age-specif…
View article: Recommendations for Reporting Ion Mobility Mass Spectrometry Measurements
Recommendations for Reporting Ion Mobility Mass Spectrometry Measurements Open
Here we present a guide on ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties on mobility …