Michael Groszmann
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View article: Clinical effectiveness of drop-in mental health services in paediatric healthcare settings: a non-randomised multi-site study for children, young people and their families
Clinical effectiveness of drop-in mental health services in paediatric healthcare settings: a non-randomised multi-site study for children, young people and their families Open
Background Despite the high prevalence of mental health disorders in children and young people with long-term health conditions, access to timely and effective treatment is often difficult. This study aimed to evaluate the clinical effecti…
View article: High water use efficiency due to maintenance of photosynthetic capacity in sorghum under water stress
High water use efficiency due to maintenance of photosynthetic capacity in sorghum under water stress Open
Environmental change requires more crop production per water use to meet the rising global food demands. However, improving crop intrinsic water use efficiency (iWUE) usually comes at the expense of carbon assimilation. Sorghum is a key cr…
View article: Clinical effectiveness of drop-in mental health services at paediatric hospitals: A non-randomised multi-site study for children and young people and their families – study protocol
Clinical effectiveness of drop-in mental health services at paediatric hospitals: A non-randomised multi-site study for children and young people and their families – study protocol Open
Background Despite the high prevalence of mental health difficulties in children and young people with long-term health conditions (LTCs), these difficulties and experiences are often overlooked and untreated. Previous research demonstrate…
View article: Arabidopsis plasma membrane intrinsic protein (AtPIP2;1) is implicated in a salinity conditional influence on seed germination
Arabidopsis plasma membrane intrinsic protein (AtPIP2;1) is implicated in a salinity conditional influence on seed germination Open
Dynamic changes in aquaporin gene expression occur during seed germination. One example is the ~30-fold increase in Arabidopsis thaliana PIP2;1 transcripts within 24 h of seed imbibition. To investigate whether AtPIP2;1 can influence seed …
View article: A high-throughput yeast approach to characterize aquaporin permeabilities: Profiling the Arabidopsis PIP aquaporin sub-family
A high-throughput yeast approach to characterize aquaporin permeabilities: Profiling the Arabidopsis PIP aquaporin sub-family Open
Introduction Engineering membrane transporters to achieve desired functionality is reliant on availability of experimental data informing structure-function relationships and intelligent design. Plant aquaporin (AQP) isoforms are capable o…
View article: 1881 Referrals to UCLH child and adolescent psychiatry liaison service: observations to guide service development and comparisons with local/national trends
1881 Referrals to UCLH child and adolescent psychiatry liaison service: observations to guide service development and comparisons with local/national trends Open
Objectives The University College London Hospital (UCLH) Child and Adolescent Psychological Medicine service provides psychiatric care to individuals under the age of 18. We provide mental health care for children and young people under th…
View article: A cross‐scale analysis to understand and quantify the effects of photosynthetic enhancement on crop growth and yield across environments
A cross‐scale analysis to understand and quantify the effects of photosynthetic enhancement on crop growth and yield across environments Open
Photosynthetic manipulation provides new opportunities for enhancing crop yield. However, understanding and quantifying the importance of individual and multiple manipulations on the seasonal biomass growth and yield performance of target …
View article: A Rapid Method for Detecting Normal or Modified Plant and Algal Carbonic Anhydrase Activity Using Saccharomyces cerevisiae
A Rapid Method for Detecting Normal or Modified Plant and Algal Carbonic Anhydrase Activity Using Saccharomyces cerevisiae Open
In recent years, researchers have attempted to improve photosynthesis by introducing components from cyanobacterial and algal CO2-concentrating mechanisms (CCMs) into terrestrial C3 plants. For these attempts to succeed, we need to underst…
View article: Mesophyll conductance is unaffected by expression of Arabidopsis <i>PIP1</i> aquaporins in the plasmalemma of <i>Nicotiana</i>
Mesophyll conductance is unaffected by expression of Arabidopsis <i>PIP1</i> aquaporins in the plasmalemma of <i>Nicotiana</i> Open
In plants with C3 photosynthesis, increasing the diffusion conductance for CO2 from the substomatal cavity to chloroplast stroma (mesophyll conductance) can improve the efficiencies of both CO2 assimilation and photosynthetic water use. In…
View article: Author response: Expression of a CO2-permeable aquaporin enhances mesophyll conductance in the C4 species Setaria viridis
Author response: Expression of a CO2-permeable aquaporin enhances mesophyll conductance in the C4 species Setaria viridis Open
View article: Working together better for mental health in children and young people during a pandemic: experiences from North Central London during the first wave of COVID-19
Working together better for mental health in children and young people during a pandemic: experiences from North Central London during the first wave of COVID-19 Open
Direct risk from infection from COVID-19 for children and young people (CYP) is low, but impact on services, education and mental health (so-called collateral damage) appears to have been more significant. In North Central London (NCL) dur…
View article: Permeability profiling of all 13 Arabidopsis PIP aquaporins using a high throughput yeast approach
Permeability profiling of all 13 Arabidopsis PIP aquaporins using a high throughput yeast approach Open
Plant aquaporins have many more functions than just transporting water. Within the diversity of plant aquaporins are isoforms capable of transporting signaling molecules, nutrients, metalloids and gases. It is established that aquaporin su…
View article: A consensus on the Aquaporin Gene Family in the Allotetraploid Plant, <i>Nicotiana tabacum</i>
A consensus on the Aquaporin Gene Family in the Allotetraploid Plant, <i>Nicotiana tabacum</i> Open
Aquaporins (AQPs) are membrane‐spanning channel proteins with exciting applications for plant engineering and industrial applications. Translational outcomes will be improved by better understanding the extensive diversity of plant AQPs. H…
View article: Expression of a CO <sub>2</sub> -permeable aquaporin enhances mesophyll conductance in the C <sub>4</sub> species <i>Setaria viridis</i>
Expression of a CO <sub>2</sub> -permeable aquaporin enhances mesophyll conductance in the C <sub>4</sub> species <i>Setaria viridis</i> Open
A fundamental limitation of photosynthetic carbon fixation is the availability of CO 4 . In C 4 plants, primary carboxylation occurs in mesophyll cytosol, and little is known about the role of CO 2 diffusion in facilitating C 4 photosynthe…
View article: Exploring the Plant Aquaporin Solute Transport Network: Functional characterisation of<i>Nicotiana tabacum</i>PIP, TIP and NIP isoforms
Exploring the Plant Aquaporin Solute Transport Network: Functional characterisation of<i>Nicotiana tabacum</i>PIP, TIP and NIP isoforms Open
Aquaporins (AQPs) are multifunctional membrane proteins which have greatly diversified in number and function in the plant Kingdom. In plants, AQPs have evolved to comprise a dynamic solute transport network occurring in all tissues and fa…
View article: Stomatal, mesophyll conductance, and biochemical limitations to photosynthesis during induction
Stomatal, mesophyll conductance, and biochemical limitations to photosynthesis during induction Open
The dynamics of leaf photosynthesis in fluctuating light affects carbon gain by plants. Mesophyll conductance (gm) limits CO2 assimilation rate (A) under the steady state, but the extent of this limitation under non-steady-state conditions…
View article: Genome-wide identification and characterisation of Aquaporins in Nicotiana tabacum and their relationships with other Solanaceae species
Genome-wide identification and characterisation of Aquaporins in Nicotiana tabacum and their relationships with other Solanaceae species Open
View article: Phosphorylation influences water and ion channel function of AtPIP2;1
Phosphorylation influences water and ion channel function of AtPIP2;1 Open
The phosphorylation states of two serine residues within the C-terminal domain of AtPIP2;1 (S280, S283) regulate its trafficking to the plasma membrane in response to salt and osmotic stress. Here we investigated whether the phosphorylatio…
View article: The Peptide Hormone Receptor CEPR1 Functions in the Reproductive Tissue to Control Seed Size and Yield
The Peptide Hormone Receptor CEPR1 Functions in the Reproductive Tissue to Control Seed Size and Yield Open
The interaction of C-TERMINALLY ENCODED PEPTIDES (CEPs) with CEP RECEPTOR1 (CEPR1) controls root growth and development, as well as nitrate uptake, but has no known role in determining yield. We used physiological, microscopic, molecular, …
View article: Manipulating Gibberellin Control Over Growth and Fertility as a Possible Target for Managing Wild Radish Weed Populations in Cropping Systems
Manipulating Gibberellin Control Over Growth and Fertility as a Possible Target for Managing Wild Radish Weed Populations in Cropping Systems Open
Wild radish is a major weed of Australian cereal crops. A rapid establishment, fast growth, and abundant seed production are fundamental to its success as an invasive species. Wild radish has developed resistance to a number of commonly us…
View article: Deciphering aquaporin regulation and roles in seed biology
Deciphering aquaporin regulation and roles in seed biology Open
Seeds are the typical dispersal and propagation units of angiosperms and gymnosperms. Water movement into and out of seeds plays a crucial role from the point of fertilization through to imbibition and seed germination. A class of membrane…
View article: Additional file 3 of Genome-wide identification and characterisation of Aquaporins in Nicotiana tabacum and their relationships with other Solanaceae species
Additional file 3 of Genome-wide identification and characterisation of Aquaporins in Nicotiana tabacum and their relationships with other Solanaceae species Open
Additional file 3: Repository of sequences examined in this study. Genomic (gff3 format), CDS, and protein sequences for all 76 NtAQPs. CDS and protein sequences for all N.sylvestris and N.tomentosiformis AQPs. Amended sequences for potato…
View article: Additional file 1 of Genome-wide identification and characterisation of Aquaporins in Nicotiana tabacum and their relationships with other Solanaceae species
Additional file 1 of Genome-wide identification and characterisation of Aquaporins in Nicotiana tabacum and their relationships with other Solanaceae species Open
Additional file 1: Table S1. Tobacco AQP pseudo genes. Table of sequences that encode for incomplete AQPs within the tobacco TN90 genome sequence (Sierro et al. 2014), that we have subsequently assigned as pseudo genes. Notes on trans-memb…
View article: Research priorities for young people with cancer: a UK priority setting partnership with the James Lind Alliance
Research priorities for young people with cancer: a UK priority setting partnership with the James Lind Alliance Open
Objectives To conduct a UK-wide survey of young people who have experienced cancer, carers and professionals, to identify and prioritise research questions to inform decisions of research funders and support the case for research with this…
View article: Senescence and Defense Pathways Contribute to Heterosis
Senescence and Defense Pathways Contribute to Heterosis Open
Hybrids are used extensively in agriculture due to their superior performance in seed yield and plant growth, yet the molecular mechanisms underpinning hybrid performance are not well understood. Recent evidence has suggested that a decrea…
View article: Twenty-four–nucleotide siRNAs produce heritable trans-chromosomal methylation in F1 <i>Arabidopsis</i> hybrids
Twenty-four–nucleotide siRNAs produce heritable trans-chromosomal methylation in F1 <i>Arabidopsis</i> hybrids Open
Significance We show that the changes in DNA methylation that occur in F1 hybrids of Arabidopsis are mostly dependent on the presence of 24-nt siRNAs at the locus. The methylation change at a locus results in the two alleles becoming simil…
View article: Carbon dioxide and water transport through plant aquaporins
Carbon dioxide and water transport through plant aquaporins Open
Aquaporins are channel proteins that function to increase the permeability of biological membranes. In plants, aquaporins are encoded by multigene families that have undergone substantial diversification in land plants. The plasma membrane…
View article: Hormone-regulated defense and stress response networks contribute to heterosis in<i>Arabidopsis</i>F1 hybrids
Hormone-regulated defense and stress response networks contribute to heterosis in<i>Arabidopsis</i>F1 hybrids Open
Significance Hybrids are extensively used in agriculture to deliver increases in crop yields, yet the molecular basis of their superior performance (heterosis) is not well understood. We report that some Arabidopsis F1 hybrids show changes…
View article: Hybrid mimics and hybrid vigor in <i>Arabidopsis</i>
Hybrid mimics and hybrid vigor in <i>Arabidopsis</i> Open
Significance Hybrids have an important role in many crops used for global food production. The increased production levels of biomass and grain are restricted to the first-generation hybrid. We report stabilization of hybrid vigor traits i…
View article: Epigenetic Changes in Hybrids
Epigenetic Changes in Hybrids Open
Genome-wide approaches to the study of hybrid vigor have identified epigenetic changes in the hybrid nucleus in Arabidopsis (Arabidopsis thaliana), maize (Zea mays), and rice (Oryza sativa). DNA methylation associated with 24-nucleotide sm…