Michael Grunert
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View article: Web-based nutrient management with the software webBESyD–Scientific principles, software architecture and model validation
Web-based nutrient management with the software webBESyD–Scientific principles, software architecture and model validation Open
Efficient on-farm nutrient management is a prerequisite for achieving high crop yields, high product quality, high nutrient use efficiency, and low nutrient losses to the environment. So far, software tools are only available for individua…
View article: The mutational landscape and its longitudinal dynamics in relapsed and refractory classic Hodgkin lymphoma
The mutational landscape and its longitudinal dynamics in relapsed and refractory classic Hodgkin lymphoma Open
In classic Hodgkin-lymphoma (cHL), only a few cases recur, and only a limited fraction of patients is primary-refractory to standard-polychemotherapy. Underlying genomic features of unfavorable clinical courses remain sparsely characterize…
View article: Interobserver Agreement in Ultrasound Risk Stratification Systems for Thyroid Nodules on Static Images Versus Cine-Loop Video Sequences
Interobserver Agreement in Ultrasound Risk Stratification Systems for Thyroid Nodules on Static Images Versus Cine-Loop Video Sequences Open
Purpose: To evaluate the impact of video sequences (cine-loops) on the interobserver agreement (IOA) using risk stratification systems (RSSs) for thyroid nodules (TNs). Methods: Twenty TNs were randomly selected from a large database and e…
View article: Molecular tumor board: molecularly adjusted therapy upon identification and functional validation of a novel <i>ALK</i> resistance mutation in a case of lung adenocarcinoma
Molecular tumor board: molecularly adjusted therapy upon identification and functional validation of a novel <i>ALK</i> resistance mutation in a case of lung adenocarcinoma Open
We report a case of a long-term surviving patient with EML4/ALK translocated non–small cell adenocarcinoma of the lung in UICC8 stage IVA. During recurrence under continuous crizotinib therapy, a hitherto insufficiently characterized misse…
View article: Late Onset of Primary Hemophagocytic Lymphohistiocytosis (HLH) with a Novel Constellation of Compound Heterozygosity Involving Two Missense Variants in the PRF1 Gene
Late Onset of Primary Hemophagocytic Lymphohistiocytosis (HLH) with a Novel Constellation of Compound Heterozygosity Involving Two Missense Variants in the PRF1 Gene Open
Hemophagocytic lymphohistiocytosis (HLH) is a rare but in most cases life-threatening immune-mediated disease of the hematopoietic system frequently associated with hematologic neoplasms. Here, we report on a case in which we detected a no…
View article: Comparison of the Effective Radiation Dose in the Region of the Facial Skull Between Multidetector CT, Dental Conebeam CT and Intraoperative 3D C-Arms
Comparison of the Effective Radiation Dose in the Region of the Facial Skull Between Multidetector CT, Dental Conebeam CT and Intraoperative 3D C-Arms Open
Study Design Experimental single-centre study of X-ray absorption using a phantom skull. Objective This experimental study aimed to compare the radiation doses of different 3D imaging devices used in maxillofacial surgery, including one Mu…
View article: Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986
Chernobyl’s Aftermath: Multiple Manifestations of Basalioma in a Patient after Radioactive Contamination in 1986 Open
Background: The Chernobyl nuclear disaster is still considered the worst nuclear accident in history. The particles were dispersed over the former USSR and large parts of Western Europe, leading to radioactive exposure to more than 10 mill…
View article: Nitrogen stabilization in fertilization practice: optimization by regionalization based on meteorological and edaphic parameters
Nitrogen stabilization in fertilization practice: optimization by regionalization based on meteorological and edaphic parameters Open
Within the R&D project StaPrax-Regio, highly efficient N-stabilized fertilization strategies are identified based on site-specific agrometeorological and soil characteristics. Derived strategies will be transferred to fertilization pra…
View article: Personalized [177Lu]Lutetium-PSMA Therapy for Patients with Pre-Treated Castration-Resistant Prostate Cancer: A Single Institution Experience from a Comprehensive Cancer Centre
Personalized [177Lu]Lutetium-PSMA Therapy for Patients with Pre-Treated Castration-Resistant Prostate Cancer: A Single Institution Experience from a Comprehensive Cancer Centre Open
Castration resistant prostate cancer (CRPC) is characterized by an aggressive biological behavior with a relatively short survival time, especially in progressive tumors pretreated with new hormonal agents and taxane chemotherapy. [177Lu]-…
View article: Integrated Thyroid Imaging: Ultrasound and Scintigraphy
Integrated Thyroid Imaging: Ultrasound and Scintigraphy Open
Thyroid sonography has made substantial progress over the last decades in terms of spatial resolution and additional parameters including vascularity, perfusion, and elasticity of lesions. The improved depictability of thyroid nodules has …
View article: Optimization of Agricultural Fertilization Strategies based on Meteorological and Edaphic parameters: Analysis of Site-Specific Geoinformation to Support Decision Making
Optimization of Agricultural Fertilization Strategies based on Meteorological and Edaphic parameters: Analysis of Site-Specific Geoinformation to Support Decision Making Open
Within the framework of the project “StaPrax-Regio”, Nitrogen-(N)-fertilization strategies will be developed aiming at the minimization of emissions of N into the environment (groundwater, air) due to non-availability for the crops. The co…
View article: Introducing a Pole Concept for Nodule Growth in the Thyroid Gland: Taller-than-Wide Shape, Frequency, Location and Risk of Malignancy of Thyroid Nodules in an Area with Iodine Deficiency
Introducing a Pole Concept for Nodule Growth in the Thyroid Gland: Taller-than-Wide Shape, Frequency, Location and Risk of Malignancy of Thyroid Nodules in an Area with Iodine Deficiency Open
Purpose: (i) To examine the criterion taller-than-wide (TTW) for the sonographic assessment of thyroid nodules in areas of iodine deficiency in terms of frequency, anatomical distribution within the thyroid gland and risk of malignancy. (i…
View article: Diagnostic Performance of Kwak, EU, ACR, and Korean TIRADS as Well as ATA Guidelines for the Ultrasound Risk Stratification of Non-Autonomously Functioning Thyroid Nodules in a Region with Long History of Iodine Deficiency: A German Multicenter Trial
Diagnostic Performance of Kwak, EU, ACR, and Korean TIRADS as Well as ATA Guidelines for the Ultrasound Risk Stratification of Non-Autonomously Functioning Thyroid Nodules in a Region with Long History of Iodine Deficiency: A German Multicenter Trial Open
Germany has a long history of insufficient iodine supply and thyroid nodules occur in over 30% of the adult population, the vast majority of which are benign. Non-invasive diagnostics remain challenging, and ultrasound-based risk stratific…
View article: Target Heterogeneity in Oncology: The Best Predictor for Differential Response to Radioligand Therapy in Neuroendocrine Tumors and Prostate Cancer
Target Heterogeneity in Oncology: The Best Predictor for Differential Response to Radioligand Therapy in Neuroendocrine Tumors and Prostate Cancer Open
Tumor or target heterogeneity (TH) implies presence of variable cellular populations having different genomic characteristics within the same tumor, or in different tumor sites of the same patient. The challenge is to identify this heterog…
View article: What Animal Cancers teach us about Human Biology
What Animal Cancers teach us about Human Biology Open
Cancers in animals present a large, underutilized reservoir of biomedical information with critical implication for human oncology and medicine in general. Discussing two distinct areas of tumour biology in non-human hosts, we highlight th…
View article: Inhibition of PI3K signalling increases the efficiency of radiotherapy in glioblastoma cells
Inhibition of PI3K signalling increases the efficiency of radiotherapy in glioblastoma cells Open
Glioblastoma, the most common primary brain tumour, is also considered one of the most lethal cancers per se. It is highly refractory to therapeutic intervention, as highlighted by the mean patient survival of only 15 months, despite an ag…