Michael H. Woodworth
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View article: Knowledge and Acceptability of Fecal Microbiota Transplantation Among Patients, Caregivers, and Health Care Providers in Ethiopia
Knowledge and Acceptability of Fecal Microbiota Transplantation Among Patients, Caregivers, and Health Care Providers in Ethiopia Open
Background Malnutrition and antimicrobial-resistant infections are major causes of morbidity and mortality in low-income countries. These conditions have been associated with the gut microbiome, although little is known about the acceptabi…
View article: Microbiota Transplantation Among Patients Receiving Long-Term Care
Microbiota Transplantation Among Patients Receiving Long-Term Care Open
Importance Intestinal multidrug-resistant organism (MDRO) colonization is highly prevalent in long-term acute care hospital (LTACH) patients and is associated with MDRO infection and transmission. However, there are no therapies approved b…
View article: State-of-the-Art Review: Infectious Diarrhea
State-of-the-Art Review: Infectious Diarrhea Open
In this review, we describe a multidisciplinary approach to the care of a patient with diarrhea, known or suspected to be the result of an infection, incorporating infectious disease, gastroenterology, microbiology, and pharmacy clinical p…
View article: Evaluation of swabbing methods for culture and non-culture-based recovery of multidrug-resistant organisms from environmental surfaces
Evaluation of swabbing methods for culture and non-culture-based recovery of multidrug-resistant organisms from environmental surfaces Open
Objectives: Sponge-Sticks (SS) and ESwabs are frequently utilized for detection of multidrug-resistant organisms (MDROs) in the environment. Head-to-head comparisons of SS and ESwabs across recovery endpoints are limited. Design: We compar…
View article: Fgl2 regulates FcγRIIB+CD8+ T cell responses during infection
Fgl2 regulates FcγRIIB+CD8+ T cell responses during infection Open
While the inhibitory receptor FcγRIIB has been shown to be upregulated on activated CD8+ T cells in both mice and humans, its effect on T cell fate during infection has not been fully elucidated. We identified an increase in FcγRIIB-expres…
View article: Leveraging strain competition to address antimicrobial resistance with microbiota therapies
Leveraging strain competition to address antimicrobial resistance with microbiota therapies Open
The enteric microbiota is an established reservoir for multidrug-resistant organisms that present urgent clinical and public health threats. Observational data and small interventional studies suggest that microbiome interventions, such as…
View article: A theoretical exploration of protocols for treating prosthetic joint infections with combinations of antibiotics and bacteriophage
A theoretical exploration of protocols for treating prosthetic joint infections with combinations of antibiotics and bacteriophage Open
With the increase in the placement of prosthetic joints and other hardware in the body has come an increase in associated infections. These infections are particularly difficult to treat due to the underlying bacteria generating matrices w…
View article: 431. Engraftment of donor derived anaerobic taxa and durable long-term multidrug resistant organism decolonization following fecal microbiota transplantation
431. Engraftment of donor derived anaerobic taxa and durable long-term multidrug resistant organism decolonization following fecal microbiota transplantation Open
Background Microbiome restoration through fecal microbiota transplantation (FMT) is a promising decolonization approach that leads to reduction in multidrug resistant organism (MDRO) colonization and infections. The precise mechanisms by w…
View article: Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome
Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome Open
Doxycycline post-exposure prophylaxis (doxy-PEP) reduces bacterial sexually transmitted infections among men who have sex with men and transgender women. Although poised for widespread clinical implementation, the impact of doxy-PEP on ant…
View article: Evaluating Real‐World Experience With Maribavir for Treatment of Refractory/Resistant Cytomegalovirus in Renal Transplant Recipients
Evaluating Real‐World Experience With Maribavir for Treatment of Refractory/Resistant Cytomegalovirus in Renal Transplant Recipients Open
Introduction Maribavir was recently approved by the FDA, expanding treatment options for post–solid‐organ transplant refractory/resistant CMV. We sought to describe the post–marketing experience with maribavir at a large academic transplan…
View article: The Role of the Gut, Urine, and Vaginal Microbiomes in the Pathogenesis of Urinary Tract Infection in Women and Consideration of Microbiome Therapeutics
The Role of the Gut, Urine, and Vaginal Microbiomes in the Pathogenesis of Urinary Tract Infection in Women and Consideration of Microbiome Therapeutics Open
The gut, urine, and vaginal microbiomes play significant roles in the pathogenesis of recurrent urinary tract infections (rUTIs). Analysis of these microbiota has shown distinct associations with urinary tract infections. Encouraging data …
View article: Recurrent <i>Clostridioides difficile</i> Infection and Outcome of Fecal Microbiota Transplantation Use: A Population-Based Assessment
Recurrent <i>Clostridioides difficile</i> Infection and Outcome of Fecal Microbiota Transplantation Use: A Population-Based Assessment Open
Background Fecal microbiota transplantation (FMT) is recommended for the treatment of recurrent Clostridioides difficile infection (rCDI). In the current study, we evaluated rates of rCDI and subsequent FMT in a large metropolitan area. We…
View article: Doxycycline post-exposure prophylaxis for sexually transmitted infections impacts the gut antimicrobial resistome
Doxycycline post-exposure prophylaxis for sexually transmitted infections impacts the gut antimicrobial resistome Open
Doxycycline post-exposure prophylaxis (doxy-PEP) reduces bacterial sexually transmitted infections (STIs) among men who have sex with men and transgender women. While poised for widespread clinical implementation, the impact of doxy-PEP on…
View article: Escape Velocity—the Launch of Microbiome Therapies
Escape Velocity—the Launch of Microbiome Therapies Open
Food and Drug Administration approval of the first microbiome therapies represents a true expansion the treatment paradigm for Clostridioides difficile but raises new questions about the future role of fecal microbiota transplantation. The…
View article: The Burden and Impact of Early Post-transplant Multidrug-Resistant Organism Detection Among Renal Transplant Recipients, 2005–2021
The Burden and Impact of Early Post-transplant Multidrug-Resistant Organism Detection Among Renal Transplant Recipients, 2005–2021 Open
Background Reducing the burden of multidrug-resistant organism (MDRO) colonization and infection among renal transplant recipients (RTRs) may improve patient outcomes. We aimed to assess whether the detection of an MDRO or a comparable ant…
View article: Advancing cytomegalovirus prevention in solid organ transplant recipients: The promise of cell‐mediated immune assays
Advancing cytomegalovirus prevention in solid organ transplant recipients: The promise of cell‐mediated immune assays Open
Cytomegalovirus (CMV) infections are a major source of morbidity and mortality in solid organ transplant recipients. Prophylactic, preemptive, and hybrid prevention strategies have traditionally been the mainstay of CMV prevention but ther…
View article: Impact of an ultrasensitive <i>Cytomegalovirus</i> quantitative nucleic acid test on <i>Cytomegalovirus</i> detection and therapy in renal transplant recipients
Impact of an ultrasensitive <i>Cytomegalovirus</i> quantitative nucleic acid test on <i>Cytomegalovirus</i> detection and therapy in renal transplant recipients Open
Background Cytomegalovirus (CMV) infection has broad implications for morbidity and mortality in renal transplant recipients (RTR). Routine surveillance for CMV replication with PCR‐based quantitative nucleic acid testing (qNAT) assays is …
View article: 312. Strain Engraftment and Gene Transfer in a Fecal Microbiota Transplantation Cohort
312. Strain Engraftment and Gene Transfer in a Fecal Microbiota Transplantation Cohort Open
Background Fecal microbiota transplantation (FMT) is a procedure that has gained popularity due to the high efficacy in treating recurrent Clostridioides difficile infections (RCDI) and other conditions associated with a dysbiotic gut micr…
View article: 703. Prevalence of Toxigenic and Non-Toxigenic <i>C. difficile</i> in Patients Admitted to an Academic-Affiliated Long Term Acute Care Hospital
703. Prevalence of Toxigenic and Non-Toxigenic <i>C. difficile</i> in Patients Admitted to an Academic-Affiliated Long Term Acute Care Hospital Open
Background Clostridioides difficile (C. difficile) is the leading hospital associated infection and is highly prevalent among patients admitted to long term care facilities (LTCFs). Both toxigenic and non-toxigenic strains of C. difficile …
View article: 2469. Comparative Genomics Uncovers Strain Diversity and Possible Unrecognized Transmission of MDROs among Hospitalized Patients
2469. Comparative Genomics Uncovers Strain Diversity and Possible Unrecognized Transmission of MDROs among Hospitalized Patients Open
Background Contamination of the healthcare environment by colonized patients is an important source of multidrug-resistant organism (MDRO) transmission. We aimed to determine MDRO room contamination of patients with MDRO clinical cultures …
View article: 1929. Evaluating Disparities in Recurrent <i>Clostridioides difficile</i> Infection (CDI) and Fecal Microbiota Transplant (FMT) Treatment using Geospatial and Social Vulnerability Analytic Tools
1929. Evaluating Disparities in Recurrent <i>Clostridioides difficile</i> Infection (CDI) and Fecal Microbiota Transplant (FMT) Treatment using Geospatial and Social Vulnerability Analytic Tools Open
Background Recurrent CDI (rCDI) can be deadly and live biotherapies such as fecal microbiota transplantation (FMT) are now recommended at 2nd recurrence. Although incidence of Clostridioides difficile infection (CDI) historically is higher…
View article: 2696. Impact of an Ultrasensitive <i>Cytomegalovirus</i> (CMV) Quantitative Nucleic Acid Test (qNAT) on CMV Detection and Therapy in Renal Transplant Recipients
2696. Impact of an Ultrasensitive <i>Cytomegalovirus</i> (CMV) Quantitative Nucleic Acid Test (qNAT) on CMV Detection and Therapy in Renal Transplant Recipients Open
Background Cytomegalovirus (CMV) infection in renal transplant recipients (RTR) impacts morbidity, mortality, and graft survival. Patients are risk-stratified based on their CMV serostatus as low risk (D-/R-), moderate risk (R+), and high …
View article: 291. A Longitudinal Study of The Effect of Fecal Microbiota Transplantation on <i>Klebsiella pneumoniae</i> and its Bacteriophages in a Patient with Long-Term Colonization
291. A Longitudinal Study of The Effect of Fecal Microbiota Transplantation on <i>Klebsiella pneumoniae</i> and its Bacteriophages in a Patient with Long-Term Colonization Open
Background Live biotherapeutic products such as fecal microbiota transplantation (FMT) show promise as therapies for conditions associated with gut microbiome composition and function, including colonization and recurrent infection with mu…
View article: Enteric Populations of<i>Escherichia coli</i>are Likely to be Resistant to Phages Due to O Antigen Expression
Enteric Populations of<i>Escherichia coli</i>are Likely to be Resistant to Phages Due to O Antigen Expression Open
There is a surfeit of bioinformatic data showing that bacteriophages abound in the enteric microbiomes of humans. What is the contribution of these viruses in shaping the bacterial strain and species composition of the gut microbiome and h…
View article: Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement
Fecal microbiota transplantation promotes reduction of antimicrobial resistance by strain replacement Open
Multidrug-resistant organism (MDRO) colonization is a fundamental challenge in antimicrobial resistance. Limited studies have shown that fecal microbiota transplantation (FMT) can reduce MDRO colonization, but its mechanisms are poorly und…
View article: ANI matrices for isolates from patients with metagenomic evidence of strain replacement
ANI matrices for isolates from patients with metagenomic evidence of strain replacement Open
Matrices of average nucleotide identity (ANI) values for all-vs-all comparisons of isolate genomes of the same species recovered from four participants in the PREMIX study. Genome IDs can be linked to publication by genome metadata found o…
View article: ANI matrices for isolates from patients with metagenomic evidence of strain replacement
ANI matrices for isolates from patients with metagenomic evidence of strain replacement Open
Matrices of average nucleotide identity (ANI) values for all-vs-all comparisons of isolate genomes of the same species recovered from four participants in the PREMIX study. Genome IDs can be linked to publication by genome metadata found o…