David M. Haas
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View article: Placental MRI texture features in prenatal exposure to opioids and tobacco
Placental MRI texture features in prenatal exposure to opioids and tobacco Open
Opioid use disorder during pregnancy significantly increases the likelihood of adverse developmental outcomes in the offspring. Texture analysis serves as a quantitative technique that could be vital in identifying microstructural variatio…
View article: Fetal Polygenic Growth Score and Risk for Large for Gestational Age Birth Weight in Nulliparas: Secondary Analysis of a Prospective Cohort Study
Fetal Polygenic Growth Score and Risk for Large for Gestational Age Birth Weight in Nulliparas: Secondary Analysis of a Prospective Cohort Study Open
Background Large for gestational age birth weight is associated with both short- and long-term health consequences for offspring, and fetal genetics may contribute to risk for large for gestational age birth weight. Objectives We evaluated…
View article: The postural impact of the gravid uterus on the renal veins and its clinical significance
The postural impact of the gravid uterus on the renal veins and its clinical significance Open
These results highlight the potential for renal venous compression and the flow-protective potential of the left lateral posture. Imaging data demonstrates renal venous compression in the supine posture and self-reported sleep data demonst…
View article: Association of Mean Arterial, Systolic, and Diastolic Blood Pressure Trends in Early Pregnancy With Superimposed Preeclampsia With Severe Features in Pregnancies Complicated by Chronic Hypertension
Association of Mean Arterial, Systolic, and Diastolic Blood Pressure Trends in Early Pregnancy With Superimposed Preeclampsia With Severe Features in Pregnancies Complicated by Chronic Hypertension Open
OBJECTIVE: To evaluate the association of longitudinal systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) in early pregnancy with later development of superimposed preeclampsia with severe featu…
View article: Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus
Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus Open
Background C-reactive protein (CRP) is a well-established biomarker of systemic inflammation. In pregnancy, several studies show association of elevated CRP with gestational diabetes mellitus (GDM). However, the genetic contributions of CR…
View article: Neighbourhood Socioeconomic Disadvantage and Severe Maternal Morbidity: Secondary Analysis of a Prospective Cohort
Neighbourhood Socioeconomic Disadvantage and Severe Maternal Morbidity: Secondary Analysis of a Prospective Cohort Open
Objective To examine whether neighbourhood socioeconomic disadvantage, as measured by the Area Deprivation Index (ADI) in early pregnancy, was associated with severe maternal morbidity (SMM) at delivery hospitalisation. Design A prospectiv…
View article: A novel two-sample Mendelian randomization framework integrating common and rare variants: application to assess the effect of HDL-C on preeclampsia risk
A novel two-sample Mendelian randomization framework integrating common and rare variants: application to assess the effect of HDL-C on preeclampsia risk Open
Mendelian randomization (MR) has become an important technique for establishing causal relationships between risk factors and health outcomes. By using genetic variants as instrumental variables, it can mitigate bias due to confounding and…
View article: Diabetes polygenic risk scores and maternal characteristics in Hoosier Moms Cohort participants
Diabetes polygenic risk scores and maternal characteristics in Hoosier Moms Cohort participants Open
Background/Objective Gestational diabetes mellitus (GDM) increases the risk of adverse perinatal outcomes. Understanding genetic‐based risk for GDM is important for clinical risk prediction. The objective of this study was to examine parti…
View article: Pharmacokinetic Characterization of Labetalol in Pregnancy (The CLIP Study): A Prospective Observational Longitudinal Pharmacokinetic/Pharmacodynamic Cohort Study During Pregnancy and Postpartum
Pharmacokinetic Characterization of Labetalol in Pregnancy (The CLIP Study): A Prospective Observational Longitudinal Pharmacokinetic/Pharmacodynamic Cohort Study During Pregnancy and Postpartum Open
Background/Objectives: Hypertensive disorders of pregnancy are a leading cause of pregnancy-related deaths in the United States, accounting for 7% of maternal mortality. Labetalol and nifedipine are the first-line drugs for the management …
View article: Reference Range Determination for the sFlt-1/PlGF Ratio in a Diverse Cohort of Pregnant Women in the United States
Reference Range Determination for the sFlt-1/PlGF Ratio in a Diverse Cohort of Pregnant Women in the United States Open
Background The serum soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio is an established tool for predicting preeclampsia in many countries but is not widely adopted in the United States. This study aimed …
View article: Pregnant maternal brain dorsal anterior cingulate cortex choline/creatine ratios on 1H-MR spectroscopy in opioid exposure
Pregnant maternal brain dorsal anterior cingulate cortex choline/creatine ratios on 1H-MR spectroscopy in opioid exposure Open
There is growing interest in understanding the effects of opioid use on the brain, yet the effects of opioid use on the pregnant maternal brain are still relatively unknown. Pregnant women with opioid exposure during pregnancy are at high …
View article: Changes in address and the Child Opportunity Index after delivery in a cohort of first-time mothers
Changes in address and the Child Opportunity Index after delivery in a cohort of first-time mothers Open
Background The Child Opportunity Index (COI) characterizes social determinants of health across the United States including education, health and environment, and social and economic factors. Analysis of how people changing addresses after…
View article: Intersectionality of individual and neighborhood‐level adverse social determinants of health in early pregnancy
Intersectionality of individual and neighborhood‐level adverse social determinants of health in early pregnancy Open
Introduction Individual‐ and neighborhood‐level social determinants of health (SDOH) have been assessed separately in pregnancy, but their relationship to one another remains uncertain. We investigated the intersectionality of three neighb…
View article: The Relationship Between Diet Quality, Residing in a Food Desert, and Psychosocial Characteristics in Early Pregnancy
The Relationship Between Diet Quality, Residing in a Food Desert, and Psychosocial Characteristics in Early Pregnancy Open
Background: Access to high quality nutrition is an important part of a healthy pregnancy, and multiple risk factors for poor maternal nutrition have been identified. Objective: The objective of this study was to examine the relationship be…
View article: Changes in Address and the Child Opportunity Index after Delivery in a Cohort of First-time Mothers
Changes in Address and the Child Opportunity Index after Delivery in a Cohort of First-time Mothers Open
Background: The Child Opportunity Index (COI) characterizes social determinants of health across the United States including education, health and environment, and social and economic factors. The objective of the study was to determine if…
View article: Prenatal Screening for Trauma Exposure and PTSD: What Happens Next?
Prenatal Screening for Trauma Exposure and PTSD: What Happens Next? Open
Background: The perinatal period is an exceptionally vulnerable time to experience posttraumatic stress disorder (PTSD). PTSD is a psychiatric disorder that occurs after experiencing at least one traumatic event and is characterized by int…
View article: First Trimester Herbicide Concentrations and Gestational Diabetes in Nulliparas
First Trimester Herbicide Concentrations and Gestational Diabetes in Nulliparas Open
Background: Environmental exposures, such as pesticides, during pregnancy have been associated with several adverse pregnancy outcomes, including miscarriage and shorter gestational length at birth. However, their relationship with gestati…
View article: Randomized Trial of Group Postpartum Care Model Improves Knowledge and Clinical Outcomes
Randomized Trial of Group Postpartum Care Model Improves Knowledge and Clinical Outcomes Open
Background In sub-Saharan Africa, the risk of obstetric complications remains high throughout the postpartum period. Objective We developed and tested a novel, integrated model of group postpartum care titled Focused-Postpartum Care (Focus…
View article: Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries
Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries Open
Enhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately po…
View article: Radon Exposure and Gestational Diabetes
Radon Exposure and Gestational Diabetes Open
Importance Understanding environmental risk factors for gestational diabetes (GD) is crucial for developing preventive strategies and improving pregnancy outcomes. Objective To examine the association of county-level radon exposure with GD…
View article: Association of neighborhood-level socioeconomic disadvantage and Life's Essential 8 in early pregnancy
Association of neighborhood-level socioeconomic disadvantage and Life's Essential 8 in early pregnancy Open
We examined whether neighborhood-level socioeconomic disadvantage per the Area Deprivation Index (ADI) was associated with maternal cardiovascular health (CVH) in early pregnancy per the American Heart Association Life's Essential 8 (LE8).…
View article: A comprehensive and bias-free machine learning approach for risk prediction of preeclampsia with severe features in a nulliparous study cohort
A comprehensive and bias-free machine learning approach for risk prediction of preeclampsia with severe features in a nulliparous study cohort Open
Preeclampsia is one of the leading causes of maternal morbidity, with consequences during and after pregnancy. Because of its diverse clinical presentation, preeclampsia is an adverse pregnancy outcome that is uniquely challenging to predi…
View article: AI-based analysis of fetal growth restriction in a prospective obstetric cohort quantifies compound risks for perinatal morbidity and mortality and identifies previously unrecognized high risk clinical scenarios
AI-based analysis of fetal growth restriction in a prospective obstetric cohort quantifies compound risks for perinatal morbidity and mortality and identifies previously unrecognized high risk clinical scenarios Open
Background Fetal growth restriction (FGR) is a leading risk factor for stillbirth, yet the diagnosis of FGR confers considerable prognostic uncertainty, as most infants with FGR do not experience any morbidity. Our objective was to use dat…
View article: Dietary Inflammatory Index Is Differentially Associated With Cardiometabolic Health After Pregnancy on the Basis of Adverse Pregnancy Outcome Exposure
Dietary Inflammatory Index Is Differentially Associated With Cardiometabolic Health After Pregnancy on the Basis of Adverse Pregnancy Outcome Exposure Open
Background Inflammatory diets may influence risk of cardiovascular disease. Subsequent cardiovascular disease is also influenced by adverse pregnancy outcomes (APOs) such as preterm birth, small‐for‐gestational‐age birth, gestational diabe…
View article: Early prediction of preeclampsia using the first trimester vaginal microbiome
Early prediction of preeclampsia using the first trimester vaginal microbiome Open
Preeclampsia is a severe obstetrical syndrome which contributes to 10-15% of all maternal deaths. Although the mechanisms underlying systemic damage in preeclampsia—such as impaired placentation, endothelial dysfunction, and immune dysregu…