Michael J. Barnett
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View article: The Serum Lipid Profile of Relapsing Multiple Sclerosis Differs Reproducibly From Healthy Controls
The Serum Lipid Profile of Relapsing Multiple Sclerosis Differs Reproducibly From Healthy Controls Open
Blood biomarkers that correlate with inflammatory demyelination or neurodegeneration are needed for early diagnosis and disease monitoring in multiple sclerosis (MS). This study aimed to identify serum lipids that are reproducibly altered …
View article: Analysis of crystallographic phase retrieval using iterative projection algorithms
Analysis of crystallographic phase retrieval using iterative projection algorithms Open
For protein crystals in which more than two thirds of the volume is occupied by solvent, the featureless nature of the solvent region often generates a constraint that is powerful enough to allow direct phasing of X-ray diffraction data. P…
View article: A note on the Hendrickson–Lattman phase probability distribution and its equivalence to the generalized von Mises distribution
A note on the Hendrickson–Lattman phase probability distribution and its equivalence to the generalized von Mises distribution Open
Hendrickson & Lattman [ Acta Cryst. (1970), B 26 , 136–143] introduced a method for representing crystallographic phase probabilities defined on the unit circle. Their approach could model the bimodal phase probability distributions that c…
View article: Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators
Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators Open
Optimization of compound 11L led to the identification of novel HIV capsid modulators, quinazolin-4-one-bearing phenylalanine derivatives, displaying potent antiviral activities against both HIV-1 and HIV-2. Notably, derivatives 12a2 and 2…
View article: Structure of a benzosulfonamide based inhibitor – 11l - bound to a disulfide stabilised HIV-1 capsid hexamer
Structure of a benzosulfonamide based inhibitor – 11l - bound to a disulfide stabilised HIV-1 capsid hexamer Open
The Human Immunodeficiency Virus Type 1 (HIV-1) continues to be a major global health issue, with infection leading to Acquired Immunodeficiency Syndrome (AIDS). Despite advances in antiviral therapy, the need for new and more effective tr…
View article: NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli
NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli Open
Trichomonas vaginalis is a human protozoan parasite that causes trichomoniasis, a prevalent sexually transmitted infection. Trichomoniasis is accompanied by a shift to a dysbiotic vaginal microbiome that is depleted of lactobacilli. Studie…
View article: Excellent real‐world outcomes of adults with Burkitt lymphoma treated with <scp>CODOX</scp>‐M/<scp>IVAC</scp> plus or minus rituximab
Excellent real‐world outcomes of adults with Burkitt lymphoma treated with <span>CODOX</span>‐M/<span>IVAC</span> plus or minus rituximab Open
Summary Treatment of Burkitt lymphoma ( BL ) with intensive, multi‐agent chemotherapy with aggressive central nervous system ( CNS ) prophylaxis results in high cure rates, although no regimen is standard of care. We examined population‐ba…
View article: Improving Revised International Prognostic Scoring System Pre-Allogeneic Stem Cell Transplantation Does Not Translate Into Better Post-Transplantation Outcomes for Patients with Myelodysplastic Syndromes: A Single-Center Experience
Improving Revised International Prognostic Scoring System Pre-Allogeneic Stem Cell Transplantation Does Not Translate Into Better Post-Transplantation Outcomes for Patients with Myelodysplastic Syndromes: A Single-Center Experience Open
The natural history of patients with myelodysplastic syndromes (MDS) is variable. The Revised International Prognostic Score (IPSS-R) is commonly used in practice to predict outcomes in patients with MDS at both diagnosis and before hemato…
View article: Outpatient Autologous Stem Cell Transplants for Multiple Myeloma—Analysis of Safety and Outcomes in a Tertiary Care Centre
Outpatient Autologous Stem Cell Transplants for Multiple Myeloma—Analysis of Safety and Outcomes in a Tertiary Care Centre Open
Background: High dose chemotherapy and autologous stem cell transplant (ASCT) is the preferred consolidation strategy in the treatment of eligible patients with multiple myeloma and related plasma cell dyscrasias. Given the high volume of …
View article: Pre-Transplant Vitamin D Deficiency is Associated with Inferior Overall Survival but not Associated with Relapse Free Survival or Cumulative Incidence of GVHD Post Adult Hematopoietic Cell Transplantation for Hematological Malignancies
Pre-Transplant Vitamin D Deficiency is Associated with Inferior Overall Survival but not Associated with Relapse Free Survival or Cumulative Incidence of GVHD Post Adult Hematopoietic Cell Transplantation for Hematological Malignancies Open
Vitamin D is known to have immuno-modulatory properties in autoimmunity and transplantation. Few previous retrospective studies in pediatric and adult hematopoietic cell transplantation (HCT) have shown variable association of pre-transpla…