Michael J. Capper
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View article: A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor
A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor Open
Our study demonstrates that encapsulating tandem nitroreductase NfsB within encapsulins, along with pore mutations, enhances enzyme activity, with cryo-EM revealing its structural architecture and multiple pore states.
View article: Targeting <i>Pf</i>CLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment
Targeting <i>Pf</i>CLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment Open
Malaria still causes over 600,000 deaths annually, with rising resistance to frontline drugs by Plasmodium falciparum increasing this number each year. New medicines with novel mechanisms of action are, therefore, urgently needed. I…
View article: Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment
Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment Open
Malaria continues to pose a significant global health threat, with the number of deaths exceeding 600,000 annually. Acquired resistance to frontline drugs by the most deadly parasite, Plasmodium falciparum, means this number is increasing …
View article: Structural pharmacology and therapeutic potential of 5-methoxytryptamines
Structural pharmacology and therapeutic potential of 5-methoxytryptamines Open
View article: Trapping of a Polyketide Synthase Module after C−C Bond Formation Reveals Transient Acyl Carrier Domain Interactions
Trapping of a Polyketide Synthase Module after C−C Bond Formation Reveals Transient Acyl Carrier Domain Interactions Open
Modular polyketide synthases (PKSs) are giant assembly lines that produce an impressive range of biologically active compounds. However, our understanding of the structural dynamics of these megasynthases, specifically the delivery of acyl…
View article: Substrate binding and inhibition of the anion exchanger 1 transporter
Substrate binding and inhibition of the anion exchanger 1 transporter Open
View article: Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter
Substrate Binding and Inhibition of the Anion Exchanger 1 Transporter Open
Anion Exchanger 1 (AE1, SLC4A1) is the primary bicarbonate (HCO 3 - ) transporter expressed in erythrocyte membranes where it mediates transport of CO 2 between lungs and other tissues via import/export of bicarbonate. It is also a key reg…
View article: Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections
Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections Open
View article: <i>Prevotella intermedia</i> produces two proteins homologous to <i>Porphyromonas gingivalis</i> HmuY but with different heme coordination mode
<i>Prevotella intermedia</i> produces two proteins homologous to <i>Porphyromonas gingivalis</i> HmuY but with different heme coordination mode Open
As part of the infective process, Porphyromonas gingivalis must acquire heme which is indispensable for life and enables the microorganism to survive and multiply at the infection site. This oral pathogenic bacterium uses a newly discovere…
View article: How the ubiquitous GPCR receptor family selectively activates signalling pathways
How the ubiquitous GPCR receptor family selectively activates signalling pathways Open
View article: The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation Open
View article: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections Open
View article: Therapeutics development against the Apicomplexa Parasites Plasmodium falciparum and Toxoplasma gondii
Therapeutics development against the Apicomplexa Parasites Plasmodium falciparum and Toxoplasma gondii Open
Apicomplexa parasites are the cause of two of the world’s most widespread diseases; malaria and toxoplasmosis. Malaria affects two billion people worldwide in some of the poorest regions of the world. Over a million people a year die from …
View article: Antimalarial 4(1H)-pyridones bind to the Q <sub>i</sub> site of cytochrome <i>bc</i> <sub>1</sub>
Antimalarial 4(1H)-pyridones bind to the Q <sub>i</sub> site of cytochrome <i>bc</i> <sub>1</sub> Open
Significance X-ray crystallography greatly benefits drug discovery work by elucidating information about the binding of drug compounds to their target. Using this information, changes to the compounds can be made in a process known as rati…