Michael J. Elmore
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View article: A full-length 16S survey using Nanopore sequencing to uncover the bacterial microbiome in Ixodes ricinus ticks from a single UK woodland, collected across three springs (2019-2021)
A full-length 16S survey using Nanopore sequencing to uncover the bacterial microbiome in Ixodes ricinus ticks from a single UK woodland, collected across three springs (2019-2021) Open
Ixodes ricinus is a key vector of several bacterial pathogens, including Borrelia and Rickettsia species. To assess bacterial prevalence and diversity, we characterised the microbiome of ticks collected from a single UK woodland, comparing…
View article: A Full-Length 16s Nanopore Sequencing Survey of the Bacterial Microbiome in Ixodes Ricinus Ticks, Comparing Life Stage and Habitat in a Single UK Woodland Across Three Springs (2019-2021)
A Full-Length 16s Nanopore Sequencing Survey of the Bacterial Microbiome in Ixodes Ricinus Ticks, Comparing Life Stage and Habitat in a Single UK Woodland Across Three Springs (2019-2021) Open
View article: Corrigendum: Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2
Corrigendum: Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2 Open
Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our princi…
View article: Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2
Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS-CoV-2 Open
The 2',5'- oligoadenylate synthetase (OAS) – ribonuclease L (RNAseL) - phosphodiesterase 12 (PDE12) pathway is an essential interferon-induced effector mechanism against RNA virus infection. Inhibition of PDE12 leads to selective amplifica…
View article: Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes
Linked Mutations in the Ebola Virus Polymerase Are Associated with Organ Specific Phenotypes Open
Ebola virus infection can have dramatic effects on the human body which manifest in Ebola virus disease. The outcome of infection is either survival or death and in the former group with the potential of longer-term health consequences and…
View article: Inhibition of Phosphodiesterase 12 results in Antiviral Activity against several RNA Viruses including SARS-CoV-2
Inhibition of Phosphodiesterase 12 results in Antiviral Activity against several RNA Viruses including SARS-CoV-2 Open
Phosphodiesterase 12 (PDE12) is a negative regulator of the type 1 interferon (IFN) response and here we show that PDE12 inhibitors (lead compounds 63 and 17) are associated with increased RNAseL activity, are well tolerated at the therape…
View article: Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction Open
Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic target. Clinically used heparins demonstrat…
View article: A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19 Open
View article: A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19 Open
SARS-CoV-2 remains a global threat to human health particularly as escape mutants emerge. There is an unmet need for effective treatments against COVID-19 for which neutralizing single domain antibodies (nanobodies) have significant potent…
View article: Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19 Open
View article: Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 Open
View article: Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations
Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations Open
Background and Purpose Currently, there are no licensed vaccines and limited antivirals for the treatment of COVID‐19. Heparin (delivered systemically) is currently used to treat anticoagulant anomalies in COVID‐19 patients. Additionally, …
View article: Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 Open
View article: Comparison of Rhesus and Cynomolgus macaques as an authentic model for COVID-19
Comparison of Rhesus and Cynomolgus macaques as an authentic model for COVID-19 Open
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to understand the pathogenesis of emerging diseases and to the…
View article: Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease
Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease Open
View article: A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction Open
View article: Unfractionated heparin inhibits live wild-type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.
Unfractionated heparin inhibits live wild-type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. Open
Background and Purpose: Currently there are no licensed vaccines and limited antivirals for the treatment of COVID-19. Heparin (delivered systemically) is currently being used to treat anticoagulant anomalies in COVID-19 patients. In addit…
View article: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 Open
View article: Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction Open
Summary Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a co-receptor with the ACE2 protein for recognition of the S1 spike protein on SARS-CoV-2 virus, providing a tractable new target for therapeutic interven…
View article: Development and Assessment of a Diagnostic DNA Oligonucleotide Microarray for Detection and Typing of Meningitis-Associated Bacterial Species
Development and Assessment of a Diagnostic DNA Oligonucleotide Microarray for Detection and Typing of Meningitis-Associated Bacterial Species Open
Meningitis is commonly caused by infection with a variety of bacterial or viral pathogens. Acute bacterial meningitis (ABM) can cause severe disease, which can progress rapidly to a critical life-threatening condition. Rapid diagnosis of A…
View article: Virus genomes reveal factors that spread and sustained the Ebola epidemic
Virus genomes reveal factors that spread and sustained the Ebola epidemic Open
View article: Whole genome protein microarrays for serum profiling of immunodominant antigens of Bacillus anthracis
Whole genome protein microarrays for serum profiling of immunodominant antigens of Bacillus anthracis Open
A commercial Bacillus anthracis (Anthrax) whole genome protein microarray has been used to identify immunogenic Anthrax proteins (IAP) using sera from groups of donors with (a) confirmed B. anthracis naturally acquired cutaneous infection,…
View article: Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa
Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa Open