Michael J. Geuenich
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View article: Integrated spatial proteomics of human PDAC uncovers an expanded tumour-immune-stroma spectrum with genomic associations
Integrated spatial proteomics of human PDAC uncovers an expanded tumour-immune-stroma spectrum with genomic associations Open
Distinctively, pancreatic ductal adenocarcinoma (PDAC) consists of sparse tumour lesions intertwined with extensive desmoplastic stroma. The complexity of tumour-microenvironment interactions within this desmoplasia poses a challenge for a…
View article: Supplementary Figure 3 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 3 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
CD8 T cell differentiation in PDA.
View article: Supplementary Figure 5 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 5 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Antigen specificity and functionality of predominant TCRs from tumors from immunotherapy treated mice.
View article: Supplementary Figure 9 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 9 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
IL15C synergizes with immunotherapy to target poorly immunogenic KPC2 tumors
View article: Data from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Data from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Agonistic anti-CD40 with anti–PD-1 can elicit objective responses in a small number of patients with pancreatic ductal adenocarcinoma (PDA). Better understanding of their individual effects on the pancreatic tumor microenvironment will hel…
View article: Supplementary Tables from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Tables from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Supplementary Tables 1-5
View article: Supplementary Figure 1 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 1 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Single cell transcriptional atlas following anti-PDL1 or agonistic anti-CD40
View article: Supplementary Figure 2 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 2 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Agonistic anti-CD40 + anti-PDL1 promotes tumor-specific CD8 T cell differentiation in spleen
View article: Supplementary Figure 7 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 7 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
A fraction of TSTEM and TEFF are in the vasculature in dLN and tumor
View article: Supplementary Figure 6 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 6 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
CD4 T cells and tumor antigen are required for anti-CD40 driven TSTEM accumulation in PDA
View article: Supplementary FIgure 8 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary FIgure 8 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
IL-15C promotes the activity of dual therapy by promoting T-bet in tumor-infiltrating T cells
View article: Supplementary Figure 4 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 4 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Comparison of human and murine tumor-infiltrating CD8 T cells.
View article: IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma
IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Agonistic anti-CD40 with anti–PD-1 can elicit objective responses in a small number of patients with pancreatic ductal adenocarcinoma (PDA). Better understanding of their individual effects on the pancreatic tumor microenvironment will hel…
View article: Interactive design and validation of antibody panels using single-cell RNA-seq atlases
Interactive design and validation of antibody panels using single-cell RNA-seq atlases Open
Single-cell RNA-sequencing holds promise for identifying novel markers of cellular variation for antibody-based technologies. However, antibody panel design is often difficult due to multiple experimental and biological constraints. We int…
View article: Inferring tumour microenvironment ecosystems from scRNA-seq atlases
Inferring tumour microenvironment ecosystems from scRNA-seq atlases Open
Accurate inference of granular cell states that co-occur within the tumour microenvironment (TME) is central to defining pro– and anti-tumour environments. Here, we describe how ecosystems of cell populations can be robustly inferred from …
View article: The impacts of active and self-supervised learning on efficient annotation of single-cell expression data
The impacts of active and self-supervised learning on efficient annotation of single-cell expression data Open
A crucial step in the analysis of single-cell data is annotating cells to cell types and states. While a myriad of approaches has been proposed, manual labeling of cells to create training datasets remains tedious and time-consuming. In th…
View article: The impacts of active and self-supervised learning on efficient annotation of single-cell expression data - source data
The impacts of active and self-supervised learning on efficient annotation of single-cell expression data - source data Open
Source data used to create all figures in the manuscript.
View article: The impacts of active and self-supervised learning on efficient annotation of single-cell expression data - source data
The impacts of active and self-supervised learning on efficient annotation of single-cell expression data - source data Open
Source data used to create all figures in the manuscript.
View article: The impacts of active and self-supervised learning on efficient annotation of single-cell expression data
The impacts of active and self-supervised learning on efficient annotation of single-cell expression data Open
A crucial step in the analysis of single-cell data is annotating cells to cell types and states. While a myriad of approaches have been proposed, manual labeling of cells to create training datasets remains tedious and time-consuming. In t…
View article: In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer
In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer Open
Functionally characterizing the genetic alterations that drive pancreatic cancer is a prerequisite for precision medicine. Here, we performed somatic CRISPR/Cas9 mutagenesis screens to assess the transforming potential of 125 recurrently m…
View article: The differential impacts of dataset imbalance in single-cell data integration
The differential impacts of dataset imbalance in single-cell data integration Open
Single-cell transcriptomic data measured across distinct samples has led to a surge in computational methods for data integration. Few studies have explicitly examined the common case of cell-type imbalance between datasets to be integrate…
View article: A noncoding single-nucleotide polymorphism at 8q24 drives <i>IDH1</i> -mutant glioma formation
A noncoding single-nucleotide polymorphism at 8q24 drives <i>IDH1</i> -mutant glioma formation Open
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase ( IDH) –mutant low-…
View article: <i>In vivo</i> CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer
<i>In vivo</i> CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer Open
Functionally characterizing the genetic alterations that drive pancreatic cancer progression is a prerequisite for Precision Medicine. Here, we developed a somatic CRISPR/Cas9 mutagenesis screen to assess the transforming potential of 125 …
View article: Automated assignment of cell identity from single-cell multiplexed imaging and proteomic data
Automated assignment of cell identity from single-cell multiplexed imaging and proteomic data Open
The creation of scalable single-cell and highly-multiplexed imaging technologies that profile the protein expression and phosphorylation status of heterogeneous cellular populations has led to multiple insights into disease processes inclu…