Michael J. Hoy
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View article: Enhanced fungal specificity and <i>in vivo</i> therapeutic efficacy of a C-22-modified FK520 analog against <i>C. neoformans</i>
Enhanced fungal specificity and <i>in vivo</i> therapeutic efficacy of a C-22-modified FK520 analog against <i>C. neoformans</i> Open
Fungal infections are of mounting global concern, and the current limited treatment arsenal poses challenges when treating such infections. In particular, infections by Cryptococcus neoformans are associated with high mortality, emphasizin…
View article: Enhanced fungal specificity and<i>in vivo</i>therapeutic efficacy of a C-22 modified FK520 analog against<i>C. neoformans</i>
Enhanced fungal specificity and<i>in vivo</i>therapeutic efficacy of a C-22 modified FK520 analog against<i>C. neoformans</i> Open
Fungal infections are of mounting global concern, and the current limited treatment arsenal poses challenges when treating such infections. In particular, infections by Cryptococcus neoformans are associated with high mortality, emphasizin…
View article: Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit <i>In Vivo</i> Therapeutic Efficacy against Cryptococcus
Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit <i>In Vivo</i> Therapeutic Efficacy against Cryptococcus Open
Due to rising rates of antifungal drug resistance and a limited armamentarium of antifungal treatments, there is a paramount need for novel antifungal drugs to treat systemic fungal infections. Calcineurin has been established as an essent…
View article: Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus
Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus Open
Calcineurin is an essential virulence factor that is conserved across human fungal pathogens including Cryptococcus neoformans , Aspergillus fumigatus , and Candida albicans . Although an excellent target for antifungal drug development, t…
View article: Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents Open
Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) and regulatory…
View article: Evolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex
Evolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex Open
The unfolded protein response (UPR) pathway, consisting of the evolutionarily conserved Ire1 kinase/endonuclease and the bZIP transcription factor Hxl1, is critical for the pathogenicity of Cryptococcus neoformans ; however, its role remai…
View article: Faculty Opinions recommendation of Exogenous Stimulation of Type I Interferon Protects Mice with Chronic Granulomatous Disease from Aspergillosis through Early Recruitment of Host-Protective Neutrophils into the Lung.
Faculty Opinions recommendation of Exogenous Stimulation of Type I Interferon Protects Mice with Chronic Granulomatous Disease from Aspergillosis through Early Recruitment of Host-Protective Neutrophils into the Lung. Open
Invasive aspergillosis (IA) remains the primary cause of morbidity and mortality in chronic granulomatous disease (CGD) patients, often due to infection by Aspergillus species refractory to antifungals.This motivates the search for alterna…
View article: Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans
Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans Open
Metabolic network rewiring is the rerouting of metabolism through the use of alternate enzymes to adjust pathway flux and accomplish specific anabolic or catabolic objectives. Here, we report the first characterization of two parallel path…