Michael J. Lee
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View article: Clinicopathologic Features of Untreated Colorectal Cancer with Acellular Mucin–Only Lymph Nodes
Clinicopathologic Features of Untreated Colorectal Cancer with Acellular Mucin–Only Lymph Nodes Open
Lymph nodes (LNs) containing only acellular mucin are considered negative for metastasis in treated colorectal cancers (CRCs). However, no data exist on how to stage these LNs in untreated CRCs. We collected 63 untreated CRC cases with LNs…
View article: Disseminated Histoplasmosis in an Immunocompetent Patient from Southern Arizona
Disseminated Histoplasmosis in an Immunocompetent Patient from Southern Arizona Open
In this review, we present a case report of an immunocompetent 58-year-old male who presented with disseminated histoplasmosis (DH) outside of the known endemic regions. Due to his atypical clinical presentation that did not fit the classi…
View article: The evolution of minimally invasive inguinal hernia repairs
The evolution of minimally invasive inguinal hernia repairs Open
Groin hernia repairs are one of the most common surgeries performed in the world. The first repairs dates back to ancient Egypt in which physicians reduced the hernia and applied heat to the hernia sac. This review article explores the evo…
View article: Mitochondria of lung venular capillaries mediate lung-liver cross talk in pneumonia
Mitochondria of lung venular capillaries mediate lung-liver cross talk in pneumonia Open
We report that mitochondrial injury in lung venular capillaries underlies barrier failure in pneumonia, and venular capillary uncoupling protein 2 (UCP2) causes neutrophil-mediated liver congestion. Using in situ imaging, we found that epi…
View article: A review of liver fibrosis and cirrhosis regression
A review of liver fibrosis and cirrhosis regression Open
Cirrhosis has traditionally been considered an irreversible process of end-stage liver disease. With new treatments for chronic liver disease, there is regression of fibrosis and cirrhosis, improvement in clinical parameters (i.e. liver fu…
View article: Functional interaction of torsinA and its activators in liver lipid metabolism
Functional interaction of torsinA and its activators in liver lipid metabolism Open
TorsinA is an atypical ATPase that lacks intrinsic activity unless it is bound to its activators lamina-associated polypeptide 1 (LAP1) in the perinuclear space or luminal domain-like LAP1 (LULL1) throughout the endoplasmic reticulum. Howe…
View article: A review of liver fibrosis and cirrhosis regression
A review of liver fibrosis and cirrhosis regression Open
Cirrhosis has traditionally been considered an irreversible process of end-stage liver disease. With new treatments for chronic liver disease, there is regression of fibrosis and cirrhosis, improvement in clinical parameters (i.e. liver fu…
View article: A-17 | In-Hospital Outcomes of Patients With Gout Complicaited by Acute ST Elevation Myocardial Infarction (STEMI)
A-17 | In-Hospital Outcomes of Patients With Gout Complicaited by Acute ST Elevation Myocardial Infarction (STEMI) Open
Background: Previous studies have shown that elevated uric acid and gout could be important risk factors for increased cardiovascular disease. However, there is a scarcity of information regarding in-hospital outcomes for patients have a S…
View article: Synthesis of silicon-substituted hemicyanines for multimodal SWIR imaging
Synthesis of silicon-substituted hemicyanines for multimodal SWIR imaging Open
SWIR dyes offer many advantages over their more common NIR congeners; however, the available options are limited. New SWIR imaging agents can be accessed by remodeling existing NIR molecules (i.e., hemicyanines (HD)). In this study, we syn…
View article: Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension
Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension Open
Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors. H…
View article: Human Polyomavirus 9—An Emerging Cutaneous and Pulmonary Pathogen in Solid Organ Transplant Recipients
Human Polyomavirus 9—An Emerging Cutaneous and Pulmonary Pathogen in Solid Organ Transplant Recipients Open
Human polyomavirus 9 was associated with the widespread cutaneous eruption. All 3 patients had progression of cutaneous disease, accompanied by clinical deterioration, pulmonary failure, and death. One patient underwent autopsy and human p…
View article: Does lumbar spine fusion predispose patients to future total hip replacement?
Does lumbar spine fusion predispose patients to future total hip replacement? Open
OBJECTIVE Hip-spine syndrome has been well studied since it was first described by Offierski and MacNab in 1983. Today, strong evidence links symptoms of hip and spine pathology to postsurgical outcomes. Recent studies have reported increa…
View article: Cross-Circulation for Extracorporeal Liver Support in a Swine Model
Cross-Circulation for Extracorporeal Liver Support in a Swine Model Open
Although machine perfusion has gained momentum as an organ preservation technique in liver transplantation, persistent organ shortages and high waitlist mortality highlight unmet needs for improved organ salvage strategies. Beyond preserva…
View article: Gunshot Wounds to the Lumbosacral Spine: Systematic Review and Meta-Analysis
Gunshot Wounds to the Lumbosacral Spine: Systematic Review and Meta-Analysis Open
Study Design: Systematic review and meta-analysis. Objectives: Indications for surgical decompression of gunshot wounds to the lumbosacral spine are controversial and based on limited data. Methods: A systematic review of literature was co…
View article: Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering
Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering Open
Cartilage, especially articular cartilage, is a unique connective tissue consisting of chondrocytes and cartilage matrix that covers the surface of joints. It plays a critical role in maintaining joint durability and mobility by providing …
View article: Malakoplakia of the gastrointestinal tract: clinicopathologic analysis of 23 cases
Malakoplakia of the gastrointestinal tract: clinicopathologic analysis of 23 cases Open
Background Malakoplakia is an uncommon, tumor-like inflammatory disease characterized by impaired histiocytes that are unable to completely digest phagocytized bacteria. The genitourinary tract is the most common site of involvement, howev…
View article: COVID-19–Associated Hepatitis Complicating Recent Living Donor Liver Transplantation
COVID-19–Associated Hepatitis Complicating Recent Living Donor Liver Transplantation Open
We present a case of COVID-19 hepatitis in a living donor liver allograft recipient whose donor subsequently tested positive for COVID-19. The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, wi…
View article: The Clinical Utility of Additional Axillary and Velpeau Radiographs in the Evaluation of Suspected Shoulder Trauma
The Clinical Utility of Additional Axillary and Velpeau Radiographs in the Evaluation of Suspected Shoulder Trauma Open
Objectives: To investigate the clinical utility of additional axillary or Velpeau views in evaluating potential shoulder trauma after a standard radiograph series of anteroposterior, Grashey, and/or trans-scapular views. Design: Retrospect…
View article: Löwenstein-buschke: clinicopathologic analysis of 78 cases of large and giant condyloma acuminata of the anus
Löwenstein-buschke: clinicopathologic analysis of 78 cases of large and giant condyloma acuminata of the anus Open
Our findings suggest that Löwenstein-Buschke lesions are mega versions of conventional condyloma. Being verrucoid, large and minimally invasive, they can be conceptually regarded as a form of verrucous carcinoma, but they do not display th…
View article: Comparing Bleeding and Thrombotic Rates in Spine Surgery: An Analysis of 119 888 Patients
Comparing Bleeding and Thrombotic Rates in Spine Surgery: An Analysis of 119 888 Patients Open
Study Design: Retrospective, database review. Objectives: Examine the utilization rate of postoperative deep vein thrombosis (DVT) prophylaxis and compare the incidence and severity of bleeding and thrombotic complications in elective spin…
View article: National trends in the diagnosis and repair of SLAP lesions in the United States
National trends in the diagnosis and repair of SLAP lesions in the United States Open
Background: Since superior labrum anterior-to-posterior (SLAP) tear was introduced as an International Classification of Diseases-Ninth Revision, Clinical Modification diagnosis in 1994, awareness, diagnosis, and surgical treatment of this…
View article: Not All SLAPs Are Created Equal: A Comparison of Patients with Planned and Incidental SLAP Repair Procedures
Not All SLAPs Are Created Equal: A Comparison of Patients with Planned and Incidental SLAP Repair Procedures Open
Background . Epidemiological studies have shown a progressive increase in the rate of superior labrum anterior-posterior (SLAP) repair surgery after the year 2000. However, it is not clear whether this is due to increased recognition of is…
View article: Correlation of ROS1 Immunohistochemistry With ROS1 Fusion Status Determined by Fluorescence In Situ Hybridization
Correlation of ROS1 Immunohistochemistry With ROS1 Fusion Status Determined by Fluorescence In Situ Hybridization Open
Context.— The ability to determine ROS1 status has become mandatory for patients with lung adenocarcinoma, as many global authorities have approved crizotinib for patients with ROS1-positive lung adenocarcinoma. Objective.— To present anal…