Michael J. Lenaeus
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View article: Modeling TCIRG1 Neutropenia by Utilizing Patient Derived Induced Pluripotent Stem Cells
Modeling TCIRG1 Neutropenia by Utilizing Patient Derived Induced Pluripotent Stem Cells Open
Congenital neutropenia is characterized by a reduced neutrophil count, decreased innate immunity and increased susceptibility to recurrent infections. While congenital neutropenia has various genetic causes, recent studies have linked TCIR…
View article: Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin
Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin Open
View article: Structural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine
Structural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine Open
View article: Fenestropathy of Voltage-Gated Sodium Channels
Fenestropathy of Voltage-Gated Sodium Channels Open
Voltage-gated sodium channels (Na v ) are responsible for the initiation and propagation of action potentials in excitable cells. From pain to heartbeat, these integral membrane proteins are the ignition stations for every sensation and ac…
View article: Data for EMSL Project 51781 from January 2022
Data for EMSL Project 51781 from January 2022 Open
View article: Data for EMSL Project 51781 from July 2022
Data for EMSL Project 51781 from July 2022 Open
View article: Open-state structure and pore gating mechanism of the cardiac sodium channel
Open-state structure and pore gating mechanism of the cardiac sodium channel Open
View article: Data for EMSL Project 51781 from September 2021
Data for EMSL Project 51781 from September 2021 Open
View article: Data for EMSL Project 51781 from January 2021
Data for EMSL Project 51781 from January 2021 Open
View article: Data for EMSL Project 51781 from January 2021
Data for EMSL Project 51781 from January 2021 Open
View article: Data for EMSL Project 51781 from January 2021
Data for EMSL Project 51781 from January 2021 Open
View article: Data for EMSL Project 51781 from February 2021
Data for EMSL Project 51781 from February 2021 Open
View article: Data for EMSL Project 51781 from September 2021
Data for EMSL Project 51781 from September 2021 Open
View article: Structure of the Cardiac Sodium Channel
Structure of the Cardiac Sodium Channel Open
View article: Structural Basis for Diltiazem Block of a Voltage-Gated Ca2+ Channel
Structural Basis for Diltiazem Block of a Voltage-Gated Ca2+ Channel Open
View article: Fenestrations Control the Resting State Block of a Voltage Gated Sodium Channel
Fenestrations Control the Resting State Block of a Voltage Gated Sodium Channel Open
View article: Fenestrations control resting-state block of a voltage-gated sodium channel
Fenestrations control resting-state block of a voltage-gated sodium channel Open
Potency of drug action is usually determined by binding to a specific receptor site on target proteins. In contrast to this conventional paradigm, we show here that potency of local anesthetics (LAs) and antiarrhythmic drugs (AADs) that bl…
View article: Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb
Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb Open
Homotetrameric bacterial voltage-gated sodium channels share major biophysical features with their more complex eukaryotic counterparts, including a slow-inactivation mechanism that reduces ion-conductance activity during prolonged depolar…
View article: NavAb Voltage-gated Sodium Channel, I217C, in Complex with Class 1C Anti-arrhythmic Flecainide
NavAb Voltage-gated Sodium Channel, I217C, in Complex with Class 1C Anti-arrhythmic Flecainide Open
Potency of drug action is usually determined by binding to a specific receptor site on target proteins. In contrast to this conventional paradigm, we show here that potency of local anesthetics (LAs) and antiarrhythmic drugs (AADs) that bl…
View article: Routine Chest Radiographs after Uncomplicated Thoracentesis
Routine Chest Radiographs after Uncomplicated Thoracentesis Open
The “Things We Do for No Reason” series reviews practices which have become common parts of hospital care, but which may provide little value to our patients. Practices reviewed in the TWDFNR series do not represent “black and white” concl…
View article: Structures of closed and open states of a voltage-gated sodium channel
Structures of closed and open states of a voltage-gated sodium channel Open
Significance Bacterial voltage-gated sodium channels serve as models of their vertebrate counterparts because they have similar functional components in a simpler structure. We present high-resolution structures of tightly closed and open …
View article: Open and Closed States of the Na V Ab Activation Gate
Open and Closed States of the Na V Ab Activation Gate Open