Michael J. Mancino
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View article: Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone.
Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone. Open
We assessed heart rate variability (HRV) as a measure of autonomic nervous system function during an ongoing double blind, placebo-controlled, trial of adjunct gabapentin during a buprenorphine-assisted taper and transition to injection na…
View article: Geographic and Racial/Ethnic Differences in Access to Methamphetamine Detoxification Services, United States, 2021
Geographic and Racial/Ethnic Differences in Access to Methamphetamine Detoxification Services, United States, 2021 Open
Introduction: Methamphetamine detoxification before entering formal and longer term treatment may have a positive impact on treatment retention and success. Understanding geographic distribution of methamphetamine specialty detox services …
View article: 484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults
484 A Preliminary Study on the Pharmacodynamics of Oral Cannabis Ingestion in Older Adults Open
OBJECTIVES/GOALS: Our study explores the dose-related effects of THC on cardiovascular measures, self-reported effects, balance, and cognitive function among older adults. We also evaluate the acceptability and feasibility of study procedu…
View article: Characteristics of patients undergoing medication-assisted treatment for opioid use disorder and their interest in Tai Chi practice
Characteristics of patients undergoing medication-assisted treatment for opioid use disorder and their interest in Tai Chi practice Open
Objectives: (1) To explore the characteristics of patients with opioid use disorder (OUD) maintained on either methadone or buprenorphine and (2) to determine the relative acceptability of integrating Tai Chi (TC) practice into an ongoing …
View article: Smartphone intervention to optimize medication-assisted treatment outcomes for opioid use disorder: study protocol for a randomized controlled trial
Smartphone intervention to optimize medication-assisted treatment outcomes for opioid use disorder: study protocol for a randomized controlled trial Open
View article: 289 Heart Rate Variability in Opioid Use Disordered Participants Undergoing Buprenorphine-Assisted Detoxification
289 Heart Rate Variability in Opioid Use Disordered Participants Undergoing Buprenorphine-Assisted Detoxification Open
OBJECTIVES/GOALS: This study explored whether gabapentin (GBN) differentially impacted heart rate variability (HRV) and whether HRV was associated with opioid withdrawal ratings among participants with opioid use disorder (OUD) undergoing …
View article: Smartphone intervention to optimize medication assisted treatment outcomes for opioid use disorder: study protocol for a randomized controlled trial
Smartphone intervention to optimize medication assisted treatment outcomes for opioid use disorder: study protocol for a randomized controlled trial Open
Background: Opioids accounted for 75% of drug overdoses in the United States in 2020, with rural states particularly impacted by the opioid crisis. While medication assisted treatment (MAT) with Suboxone remains one of the more efficacious…
View article: Utility of a controlled amphetamine withdrawal paradigm among adults who use methamphetamine: A pilot clinical trial
Utility of a controlled amphetamine withdrawal paradigm among adults who use methamphetamine: A pilot clinical trial Open
Background: The continued increase in prevalence of methamphetamine use in the United States has resulted in a significant increase in the number of patients entering treatment for methamphetamine use. However, no robustly efficacious phar…
View article: Development and validation of a rapid liquid chromatography/tandem mass spectrometry method to quantitate gabapentin and buprenorphine in human serum
Development and validation of a rapid liquid chromatography/tandem mass spectrometry method to quantitate gabapentin and buprenorphine in human serum Open
Rationale Gabapentin has shown initial promise as an opioid‐sparing medication in pain patients as well as a treatment for opioid withdrawal and liquid chriomatography/tandem mass spectrometry (LC/MS/MS) is often used for clinical monitori…
View article: Author response for "Development and Validation of a Rapid LC‐MS/MS based Method to Quantitate Gabapentin and Buprenorphine in Human Serum"
Author response for "Development and Validation of a Rapid LC‐MS/MS based Method to Quantitate Gabapentin and Buprenorphine in Human Serum" Open
View article: Feasibility and Preliminary Efficacy of Isradipine During Outpatient Buprenorphine Stabilization and Detoxification: A Pilot Randomized, Placebo-Controlled Trial
Feasibility and Preliminary Efficacy of Isradipine During Outpatient Buprenorphine Stabilization and Detoxification: A Pilot Randomized, Placebo-Controlled Trial Open
Background: Given the immense burden of the widespread use of opioids around the world, exploring treatments that improve drug use outcomes, and craving and withdrawal measures in individuals with opioid use disorder is crucial. This pilot…
View article: Survey of Treatment Preferences for Opioid Use Disorder.
Survey of Treatment Preferences for Opioid Use Disorder. Open
These preliminary results suggest that those with prior, failed experience with opioid agonist maintenance treatment are more likely to consider injection NTX therapy, suggesting it may be optimal as a second-line treatment for OUD.
View article: Prevention of Suicidal Behavior in prison: first Italian results
Prevention of Suicidal Behavior in prison: first Italian results Open
Background
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\nSuicide is one of the most common causes of death in custody worldwide, with rates substantially higher than in the general population. In 2014 a new biphasic protocol was created in Tuscany (Italy) with the aim to develop …
View article: 2255
2255 Open
OBJECTIVES/SPECIFIC AIMS: (1) Characterize the prevalence and initial pharmacological management of chronic pain syndromes during pregnancy in a women’s mental health program. (2) Describe the severity and qualitative characteristics of ch…
View article: Preventing prisoners’ suicide and autolesionism in Italy
Preventing prisoners’ suicide and autolesionism in Italy Open
View article: 1.I. Pitch presentations: Promoting mental health
1.I. Pitch presentations: Promoting mental health Open
Suicide is a complex phenomenon, and represents the 3rd cause of death in prison.In Italy about 10 suicides per 10,000 inmates and about 150 attempted suicides of 10,000 inmates occur.These data are considerably higher than the general pop…