Michael J. Moritz
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View article: Pregnancy after kidney transplantation: global insights based on registry data from three continents
Pregnancy after kidney transplantation: global insights based on registry data from three continents Open
Background Lack of data regarding pregnancy post-kidney transplantation challenges clinicians who are faced with complex, high-risk cases. Aiming at tackling knowledge gaps and limited cross-cultural data on pregnancy in kidney transplant …
View article: Prevalence of major malformations and small for gestational age in newborns of female transplant recipients on tacrolimus-containing regimens during pregnancy
Prevalence of major malformations and small for gestational age in newborns of female transplant recipients on tacrolimus-containing regimens during pregnancy Open
In female transplant recipients, immunosuppressant use during pregnancy raises potential concerns about adverse maternal and fetal outcomes. This noninterventional study used prospectively and retrospectively reported cases from the Transp…
View article: Micro- and nanoplastics reduce the phagocytosis and intracellular killing of E. coli by THP1-Blue™ NFκB monocytes
Micro- and nanoplastics reduce the phagocytosis and intracellular killing of E. coli by THP1-Blue™ NFκB monocytes Open
Purpose Micro- and nanoplastic particles occur ubiquitously in the environment and have been detected in various organs in animals and humans. We studied, how micro- and nanoplastic influence phagocytosis and intracellular killing of live …
View article: Pregnancy After Solid Organ Transplantation: Review of the Evidence and Recommendations
Pregnancy After Solid Organ Transplantation: Review of the Evidence and Recommendations Open
Solid organ transplantation (SOT) offers people with end-stage organ disease an increased quality of life, which includes the return of fertility and the potential for pregnancy. Although the number of pregnancies has increased, definitive…
View article: Heart Transplant and Pregnancy
Heart Transplant and Pregnancy Open
There was no difference in graft loss from delivery in HTRs who developed preeclampsia during pregnancy. Regardless of preeclampsia, pregnant HTRs are more likely than the general population to experience severe maternal morbidity. These f…
View article: Safety of a trial of labor after cesarean in kidney and liver transplant recipients: A multicenter cohort study
Safety of a trial of labor after cesarean in kidney and liver transplant recipients: A multicenter cohort study Open
Objective To evaluate the trends, safety, and feasibility of a trial of labor after cesarean (TOLAC) among kidney and liver transplant recipients. Methods This was a retrospective cohort study using the Transplant Pregnancy Registry Intern…
View article: Unintended Pregnancy After Kidney Transplantation
Unintended Pregnancy After Kidney Transplantation Open
OBJECTIVE: To define risk factors, obstetric morbidity, and allograft outcomes associated with an unintended pregnancy after kidney transplant. METHODS: This is a retrospective cohort study of pregnancies in women after kidney transplantat…
View article: Pregnancy in Transplant Patients
Pregnancy in Transplant Patients Open
Solid organ transplantation is not uncommon and survival rates have increased, thus there are greater numbers of women of childbearing potential who have had a transplant. This chapter reviews the outcomes of pregnancy after solid organ tr…
View article: Pregnancy after deceased donor vs living donor kidney transplant: associated obstetric and graft outcomes
Pregnancy after deceased donor vs living donor kidney transplant: associated obstetric and graft outcomes Open
Although our study demonstrated an association between deceased donor transplant and graft loss after pregnancy, it did not provide evidence that pregnancy itself causes graft loss. Recipients of a deceased donor kidney transplant should n…
View article: Outcomes With Belatacept Exposure During Pregnancy in Kidney Transplant Recipients: A Case Series
Outcomes With Belatacept Exposure During Pregnancy in Kidney Transplant Recipients: A Case Series Open
Background. Posttransplant fertility returns quickly, and female recipients of child-bearing age may conceive while on immunosuppression. However, pregnancy after transplantation confers risks to the recipient, transplant, and fetus, inclu…
View article: Emergent prelabor cesarean delivery in solid organ transplant recipients: associated risk factors and outcomes
Emergent prelabor cesarean delivery in solid organ transplant recipients: associated risk factors and outcomes Open
Almost one-third of kidney and liver transplant recipients admitted antepartum had an emergency prelabor cesarean delivery, and 63% of this cohort delivered outside of a transplant center. Pregnancies after transplantation should involve m…
View article: Mode of Obstetric Delivery in Kidney and Liver Transplant Recipients and Associated Maternal, Neonatal, and Graft Morbidity During 5 Decades of Clinical Practice
Mode of Obstetric Delivery in Kidney and Liver Transplant Recipients and Associated Maternal, Neonatal, and Graft Morbidity During 5 Decades of Clinical Practice Open
In this cohort study, TOL vs a scheduled CD was associated with improved neonatal outcomes among kidney and transplant recipients and not with increased severe maternal morbidity among kidney transplant recipients. These findings may be us…
View article: Donor-derived Ehrlichiosis: 2 Clusters Following Solid Organ Transplantation
Donor-derived Ehrlichiosis: 2 Clusters Following Solid Organ Transplantation Open
Ehrlichiosis has been infrequently described as transmissible through organ transplantation. Two donor-derived clusters of ehrlichiosis are described here. During the summer of 2020, 2 cases of ehrlichiosis were reported to the Organ Procu…
View article: Differentiating Acute Rejection From Preeclampsia After Kidney Transplantation
Differentiating Acute Rejection From Preeclampsia After Kidney Transplantation Open
OBJECTIVE: To evaluate the clinical and laboratory characteristics in pregnancy that differentiate preeclampsia from acute renal allograft rejection and to investigate the maternal, neonatal, and graft sequelae of these diagnoses. METHODS:…
View article: Belatacept during pregnancy in renal transplant recipients: Two case reports
Belatacept during pregnancy in renal transplant recipients: Two case reports Open
Impaired fertility is common among patients with chronic organ failure, including end-stage renal disease (ESRD). Women of childbearing age undergoing transplantation may experience rapid return of fertility. Pregnancy posttransplant prese…
View article: Reproductive health in women following abdominal organ transplant
Reproductive health in women following abdominal organ transplant Open
Fertility is commonly impaired in women with end-stage kidney and liver disease, although most women will have restoration of fertility within 1 year of transplant. Family planning is therefore critical to discuss with reproductive-aged tr…
View article: Update on the Teratogenicity of Maternal Mycophenolate Mofetil
Update on the Teratogenicity of Maternal Mycophenolate Mofetil Open
Mycophenolic acid (MPA) products, namely mycophenolate mofetil and mycophenolate sodium, are immunosuppressive medications used to prevent rejection in solid organ transplant recipients and to treat various autoimmune disorders. Mycophenol…