Explanipedia

Designed for simplicity, used for complexity: The systemic pressures shaping walk-in clinic practices and outcomes Open

Braeden A. Terpou, Lauren Lapointe‐Shaw, Ruoxi Wang, Danielle Martin, Mina Tadrous , et al. · 2025

Walk-in clinics (WICs), appreciated for their accessibility and convenience, have become an increasingly popular healthcare option in Ontario for patients with and without primary care enrolment. Despite their utility, WICs face criticism …

Chronic disease prevalence and preventive care among Ontario social housing residents compared with the general population: a population-based cohort study Open

Gina Agarwal, Homa Keshavarz, Ricardo Angeles, Melissa Pirrie, Francine Marzanek , et al. · 2025

Background Older adults living in social housing report poor health and access to healthcare services. This study aimed to estimate the prevalence of chronic diseases, influenza vaccination and cancer screenings among social housing reside…

SARS-CoV-2 testing, test positivity and vaccination in social housing residents compared with the general population: a retrospective population-based cohort study Open

Gina Agarwal, Homa Keshavarz, Ricardo Angeles, Melissa Pirrie, Francine Marzanek , et al. · 2024

Background The consideration of unique social housing needs has largely been absent from the COVID-19 response, particularly in tailoring strategies to improve access to testing and vaccine uptake among vulnerable and high-risk populations…

Health Care Utilization After a Visit to a Within-Group Family Physician vs a Walk-In Clinic Physician Open

Christine Salahub, Peter C. Austin, Li Bai, Simon Berthelot, R. Sacha Bhatia , et al. · 2024

Compared to visiting a walk-in clinic physician, seeing a within-group physician after hours might decrease downstream emergency department visits. This finding could be explained by better continuity of care and can inform primary care se…

An update on ICES’ Applied Health Research Question (AHRQ) program: Informing public health policy and practice using linked, population-based administrative health data in a collaborative model. Open

Diana An, Minnie Ho, J. Michael Paterson, Refik Saskin, Luke Mondor , et al. · 2024

ObjectiveTo provide an update on the key characteristics, refinements to project flow, and future opportunities for a program providing customized research evidence to health system policymakers and providers. ApproachWith a goal to inform…

Conceptualizing community data governance for race-related, population data: a scoping review and key informant interviews Open

Elise Leong-Sit, Laura Legere, Sabella Yussuf-Homenauth, Astrid Guttmann, Baiju R. Shah , et al. · 2024

ObjectiveThere is growing recognition of the importance of community data governance to build accountability of research institutions to communities. Our organization, a steward of health and administrative population-level data, has previ…

Cost Evaluation of the Ontario Virtual Urgent Care Pilot Program: Population-Based, Matched Cohort Study Open

Jean‐Éric Tarride, Justin N. Hall, Shawn Mondoux, Katie N. Dainty, Joy McCarron , et al. · 2024

Background In 2020, the Ministry of Health (MoH) in Ontario, Canada, introduced a virtual urgent care (VUC) pilot program to provide alternative access to urgent care services and reduce the need for in-person emergency department (ED) vis…

Association between immigration status and total knee arthroplasty outcomes in Ontario, Canada: a population-based matched cohort study Open

Johnathan R. Lex, Daniel Pincus, J. Michael Paterson, Jessica Widdifield, Harman Chaudhry , et al. · 2024

Compared with Canadian-born patients, immigrants and refugees have favourable surgical outcomes and similar rates of resource utilization after TKA. We observed an underutilization of these procedures in Ontario relative to their proportio…

Hyponatremia‐associated hospital visits are not reduced by early electrolyte testing in older adults starting antidepressants Open

Natasha E. Lane, Li Bai, Dallas Seitz, David N. Juurlink, J. Michael Paterson , et al. · 2024

Background Clinical practice guidelines recommend early serum electrolyte monitoring when starting antidepressants in older adults due to the increased risk of hyponatremia. It is unclear whether this monitoring improves outcomes. Methods …

Opioid-related deaths between 2019 and 2021 across 9 Canadian provinces and territories Open

Shaleesa Ledlie, David N. Juurlink, Mina Tadrous, Muhammad Mamdani, J. Michael Paterson , et al. · 2024

Across Canada, the burden of premature opioid-related deaths doubled between 2019 and 2021, representing more than one-quarter of deaths among younger adults. The disproportionate loss of life in this demographic group highlights the criti…

Risk of Arterial and Venous Thrombotic Events Among Patients with COVID-19: A Multi-National Collaboration of Regulatory Agencies from Canada, Europe, and United States Open

Vincent Lo Re, Noelle M. Cocoros, Rebecca A. Hubbard, Sarah K. Dutcher, Craig Newcomb , et al. · 2024

There was heterogeneity by country in 90-day absolute risk of ATE and VTE after ambulatory COVID-19 diagnosis both before and during COVID-19 vaccine availability.

Characteristics of Walk-In Clinic Physicians and Patients in Ontario, Canada: A Cross-Sectional Study Open

Lauren Lapointe‐Shaw, Christine Salahub, Peter C. Austin, Li Bai, Sundeep Banwatt , et al. · 2024

Objective We aimed to describe family physicians who primarily practice in a walk-in clinic setting and compare them to family physicians who provide longitudinal care. Design A cross-sectional study that linked results from an annual phys…

Exposure to valsartan products containing nitrosamine impurities in the US, Canada, and Denmark Open

Efe Eworuke, Mayura Shinde, Laura Hou, J. Michael Paterson, Peter Bjødstrup Jensen , et al. · 2023

Background Following the mass recall of valsartan products with nitrosamine impurities in July 2018, the number of patients exposed to these valsartan products, the duration of exposure, and the potential for cancer remains unknown. Theref…

Estimating the completeness of physician billing claims for diabetes case ascertainment: a multiprovince investigation Open

Joellyn Ellison, Yong Jun Gao, Kimberley Hutchings, Sharon Bartholomew, Hélène Gardiner , et al. · 2023

Introduction Previous research has suggested that how physicians are paid may affect the completeness of billing claims for estimating chronic disease. The purpose of this study is to estimate the completeness of physician billings for di…

Prescription ranitidine use and population exposure in 6 Canadian provinces, 1996 to 2019: a serial cross-sectional analysis Open

Adrian R. Levy, David Stock, J. Michael Paterson, Hala Tamim, Dan Château , et al. · 2023

Over the 24-year period in 6 provinces, patients aged 65 years and older were dispensed 2.4 million prescriptions of ranitidine and younger adults were dispensed 1.7 million prescriptions of ranitidine. These estimates of ranitidine exposu…

Validity of diagnoses of SARS-CoV-2 infection in Canadian administrative health data: a multiprovince, population-based cohort study Open

Lisa M. Lix, Christel Renoux, Carolina Moriello, Ko Long Choi, Colin R. Dormuth , et al. · 2023

We found variations in the validity of diagnoses for SARS-CoV-2 infection recorded in different health care settings, geographic areas and over time. Our multiprovince validation study provides evidence about the potential use of inpatient…

Prescription of oxycodone versus codeine after childbirth and risk of persistent opioid use: a population-based cohort study Open

Jonathan S. Zipursky, Karl Everett, Tara Gomes, J. Michael Paterson, Ping Li , et al. · 2023

Initiation of oxycodone (v. codeine) was not associated with an increased risk of persistent opioid use, except after vaginal delivery.

Residual Risk of Breast Cancer After Bariatric Surgery Open

Aristithes G. Doumouras, Olivia Lovrics, J. Michael Paterson, Rinku Sutradhar, Lawrence Paszat , et al. · 2023

Importance Excess adiposity confers higher risk of breast cancer for women. For women who have lost substantial weight, it is unclear whether previous obesity confers residual increased baseline risk of breast cancer compared with peers wi…

Walk-in clinic patient characteristics and utilization patterns in Ontario, Canada: a cross-sectional study Open

Lauren Lapointe‐Shaw, Tara Kiran, Christine Salahub, Peter C. Austin, Simon Berthelot , et al. · 2023

Our findings suggest that proximity of walk-in clinics and after-hours access may be contributing to walk-in clinic use among patients enrolled with a family physician. These findings have implications for policy development to improve the…

Changing patterns of opioid initiation for pain management in Ontario, Canada: A population-based cross-sectional study Open

Tara Gomes, Siyu Men, Tonya Campbell, Mina Tadrous, Muhammad Mamdani , et al. · 2022

Introduction The recent publication of a national guideline and quality standards in Canada have provided clinicians with new, evidence-based recommendations on safe, appropriate opioid use. We sought to characterize how well opioid initia…

Patterns of antiemetic medication use during pregnancy: A multi-country retrospective cohort study Open

Anat Fisher, J. Michael Paterson, Brandace Winquist, Fangyun Wu, Pascal Reynier , et al. · 2022

Objective To compare patterns in use of different antiemetics during pregnancy in Canada, the United Kingdom, and the United States, between 2002 and 2014. Methods We constructed population-based cohorts of pregnant women using administrat…

Risk of SARS-CoV-2 infection following initial COVID-19 vaccination: Population-based cohort study Open

Mina Tadrous, Hannah Chung, Siyu Men, Cherry Chu, Tonya Campbell , et al. · 2022

Background Anecdotally there are reports of newly diagnosed SARS-CoV-2 infection shortly after vaccination. This has led some to speculate that vaccination itself might inadvertently increase the short-term risk of COVID potentially due to…

Characteristics of new users of recent antidiabetic drugs in Canada and the United Kingdom Open

Vanessa C. Brunetti, Audray St-Jean, Sophie Dell’Aniello, Anat Fisher, Oriana Hoi Yun Yu , et al. · 2022

Background Characteristics of patients using newer 2 nd and 3 rd line antidiabetic drugs in a real-world setting are poorly understood. We described the characteristics of new users of sodium-glucose co-transporter-2 inhibitors (SGLT-2i), …

Survival after surgery for spinal metastases: a population-based study Open

Kunal Bhanot, Jessica Widdifield, Anjie Huang, J. Michael Paterson, David Shultz , et al. · 2022

We identified differential survivorship based on primary tumour type and a shift in the distribution of operations performed for specific primary cancers over the past 2 decades in Ontario. Overall reductions in mortality associated with t…

Pivoting data and analytic capacity to support Ontario’s COVID-19 response Open

Hannah Chung, Mahmoud Azimaee, Susan E. Bronskill, Rosario G Cartagena, Astrid Guttmann , et al. · 2022

IntroductionHealth care systems have faced unprecedented challenges due to the COVID-19 pandemic. Access to timely population-based data has been vital to informing public health policy and practice. MethodsWe describe how ICES, an indepen…

How much is enough for total knee arthroplasty? Open

Caesar Wek, Tosan Okoro, Sebastian Tomescu, J. Michael Paterson, Bheeshma Ravi · 2021

We welcome Professor Randsborg's suggestions that in addition to surgical volume, environmental factors such as institutional structures and patient demographics also impact on patient outcomes following total knee arthroplasty (TKA). Howe…

Comparison of 4-Year Health Care Expenditures Associated With Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy Open

Jean‐Éric Tarride, Aristithes G. Doumouras, Dennis Hong, J. Michael Paterson, Semra Tibebu , et al. · 2021

In this Canadian population-based study, key results indicated that 4-year health care expenditures, all-cause mortality, and number of hospital admissions associated with RYGB did not significantly differ from those for sleeve gastrectomy…

Association of Surgical Experience With Risk of Complication in Total Hip Arthroplasty Among Patients With Severe Obesity Open

Alexander Charalambous, Daniel Pincus, Sasha High, Fok‐Han Leung, Suriya Aktar , et al. · 2021

Increased surgeon experience performing THA in patients with severe obesity was associated with fewer major surgical complications. These findings suggest that surgeon experience is required to mitigate the unique anatomical challenges pos…

Acute Care Visits for Assault and Maltreatment Before vs During the COVID-19 Pandemic in Ontario, Canada Open

Natasha Saunders, Lesley Plumptre, Christina Diong, Sima Gandhi, Michael J. Schull , et al. · 2021

This cross-sectional study compares rates of emergency department visits and hospitalizations for assault and maltreatment by age category and sex in Ontario, Canada, before vs during the COVID-10 pandemic.

Impact of changes in opioid funding and clinical policies on rapid tapering of opioids in Ontario, Canada Open

Diana Martins, Wayne Khuu, Mina Tadrous, Simón Greaves, Beth Sproule , et al. · 2021

Reports have emerged of abrupt tapering among recipients of long-term prescription opioids to conform new prescribing guidelines. We conducted a population-based, repeated cross-sectional time-series study among very high-dose (≥200 MME) o…

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