Michael J Properzi
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View article: Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test
Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test Open
Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disea…
View article: Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease
Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease Open
Physical inactivity is a recognized modifiable risk factor for Alzheimer's disease (AD), yet its relationship with progression of AD pathology in humans remains unclear, limiting the effective translation into prevention trials. Using pedo…
View article: Estimating the preclinical Alzheimer's disease course with multimodal data
Estimating the preclinical Alzheimer's disease course with multimodal data Open
INTRODUCTION In observational studies of preclinical AD, an arbitrary “baseline” can obscure where an individual is located along a theoretical continuum. Optimizing longitudinal trajectories can distill multiple, non‐linearly distributed …
View article: BrainAge moderates associations between Alzheimer’s disease biomarkers and cognitive decline: a meta-analysis across A4/LEARN, HABS and ADNI cohorts
BrainAge moderates associations between Alzheimer’s disease biomarkers and cognitive decline: a meta-analysis across A4/LEARN, HABS and ADNI cohorts Open
BrainAge delta, the difference between a person’s predicted brain age and their chronological age, is a promising marker of the accumulation of neurodegeneration that may increase vulnerability to Alzheimer’s disease (AD). We examined whet…
View article: Relationship between BrainAge Polygenetic Risk Score and plasma biomarkers in the A4/LEARN studies
Relationship between BrainAge Polygenetic Risk Score and plasma biomarkers in the A4/LEARN studies Open
Background and Objectives To examine the association between genetic predisposition to accelerated brain aging—measured with polygenic risk scores (PRS) derived from BrainAge models—and plasma biomarkers of Alzheimer’s disease (AD), with a…
View article: The Mobile Toolbox for remote, self‐administered cognitive assessment in older adults: associations with in‐clinic cognitive testing and Alzheimer's disease biomarkers
The Mobile Toolbox for remote, self‐administered cognitive assessment in older adults: associations with in‐clinic cognitive testing and Alzheimer's disease biomarkers Open
INTRODUCTION Remote, smartphone‐based cognitive assessments such as the Mobile Toolbox (MTB) may increase the accessibility of Alzheimer's disease (AD) clinical trials. We examined the feasibility of the MTB among cognitively unimpaired (C…
View article: Plasma Phosphorylated <scp>Tau181</scp> as a Biomarker for Alzheimer's Disease Co‐Pathology in Lewy Body Disease
Plasma Phosphorylated <span>Tau181</span> as a Biomarker for Alzheimer's Disease Co‐Pathology in Lewy Body Disease Open
Background Plasma phosphorylated tau181 (pTau181) is proving to be a useful predictor of Alzheimer's disease (AD). AD co‐pathology is frequently observed across the Lewy body disease (LBD) spectrum. Objective To determine whether pTau181 i…
View article: Associations between hormone therapy use and tau accumulation in brain regions vulnerable to Alzheimer’s disease
Associations between hormone therapy use and tau accumulation in brain regions vulnerable to Alzheimer’s disease Open
Elucidating the downstream impact of exogenous hormones on the aging brain will have far-reaching consequences for understanding why Alzheimer’s disease (AD) predominates in women almost twofold over men. We tested the extent to which meno…
View article: Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease
Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease Open
Cognitive resilience (CR) describes the phenomenon of individuals evading cognitive decline despite prominent Alzheimer's disease neuropathology. Operationalization and measurement of this latent construct is non-trivial as it cannot be di…
View article: Rethinking the residual approach for estimating cognitive resilience and resistance to AD pathology
Rethinking the residual approach for estimating cognitive resilience and resistance to AD pathology Open
Background The residual approach has found wide application in researching cognitive resilience, a phenomenon conceptually understood as cognitive performance being better‐than‐typical for an individual, despite apparent AD pathology. The …
View article: Accelerated Temporal Cortex Tau Accumulation Mediates the Effects of Low Physical Activity on Faster Cognitive Decline in Preclinical Alzheimer's Disease
Accelerated Temporal Cortex Tau Accumulation Mediates the Effects of Low Physical Activity on Faster Cognitive Decline in Preclinical Alzheimer's Disease Open
Background Physically inactivity is associated with increased risk of dementia including Alzheimer’s disease (AD). Prior work from the Harvard Aging Brain Study (HABS) suggests that lower baseline physical activity in cognitively unimpaire…
View article: Sex, menopause, and hormone therapy moderate the PET tau and Aβ association in cognitively unimpaired adults with Down Syndrome: Findings from the Alzheimer Biomarkers Consortium — Down Syndrome
Sex, menopause, and hormone therapy moderate the PET tau and Aβ association in cognitively unimpaired adults with Down Syndrome: Findings from the Alzheimer Biomarkers Consortium — Down Syndrome Open
Background Virtually all adults with Down Syndrome(DS) show Alzheimer’s disease(AD)‐related pathologic change by the age of 40 years. While sex differences in Aß‐dependent tauopathy are apparent during early sporadic AD, sex differences in…
View article: Sex, menopause, and hormone therapy moderate the PET tau and Aβ association in cognitively unimpaired adults with Down Syndrome: Findings from the Alzheimer Biomarkers Consortium — Down Syndrome
Sex, menopause, and hormone therapy moderate the PET tau and Aβ association in cognitively unimpaired adults with Down Syndrome: Findings from the Alzheimer Biomarkers Consortium — Down Syndrome Open
Background Virtually all adults with Down Syndrome(DS) show Alzheimer’s disease(AD)‐related pathologic change by the age of 40 years. While sex differences in Aβ‐dependent tauopathy are apparent during early sporadic AD, sex differences in…
View article: Left frontoparietal control network connectivity moderates the effect of amyloid on cognitive decline in preclinical Alzheimer’s disease
Left frontoparietal control network connectivity moderates the effect of amyloid on cognitive decline in preclinical Alzheimer’s disease Open
Background Stronger default mode (DMN) and bilateral frontoparietal control network (FPCN) resting‐state functional connectivity are associated with reduced β‐amyloid (Aβ)‐related cognitive decline in cognitively unimpaired older adults, w…
View article: Accelerated Temporal Cortex Tau Accumulation Mediates the Effects of Low Physical Activity on Faster Cognitive Decline in Preclinical Alzheimer’s Disease
Accelerated Temporal Cortex Tau Accumulation Mediates the Effects of Low Physical Activity on Faster Cognitive Decline in Preclinical Alzheimer’s Disease Open
Background Physically inactivity is associated with increased risk of dementia including Alzheimer’s disease (AD). Prior work from the Harvard Aging Brain Study (HABS) suggests that lower baseline physical activity in cognitively unimpaire…
View article: Examining the impact of hormone therapy and Alzheimer’s disease risk factors on depressive symptoms in the Harvard Aging Brain Study
Examining the impact of hormone therapy and Alzheimer’s disease risk factors on depressive symptoms in the Harvard Aging Brain Study Open
Background Hormone therapy (HT) is often used to manage symptoms related to menopause, but its longer‐term effects on depressive symptoms in older women remains unclear. Previous literature reports inconclusive results on whether HT use is…
View article: Left frontoparietal control network connectivity moderates the effect of amyloid on cognitive decline in preclinical Alzheimer’s disease
Left frontoparietal control network connectivity moderates the effect of amyloid on cognitive decline in preclinical Alzheimer’s disease Open
Background Stronger default mode (DMN) and bilateral frontoparietal control network (FPCN) resting‐state functional connectivity are associated with reduced ß‐amyloid (Aß)‐related cognitive decline in cognitively unimpaired older adults, w…
View article: Latent change‐on‐change between amyloid accumulation and cognitive decline
Latent change‐on‐change between amyloid accumulation and cognitive decline Open
INTRODUCTION While the influence of cross‐sectional β‐amyloid (Aβ) on longitudinal changes in cognition is well established, longitudinal change‐on‐change between Aβ and cognition is less explored. METHODS A series of bivariate latent chan…
View article: Change in Depressive Symptoms and Longitudinal Regional Amyloid Accumulation in Unimpaired Older Adults
Change in Depressive Symptoms and Longitudinal Regional Amyloid Accumulation in Unimpaired Older Adults Open
Importance Depressive symptoms in older adults may be a harbinger of Alzheimer disease (AD), even in preclinical stages. It is unclear whether worsening depressive symptoms are manifestations of regional distributions of core AD pathology …
View article: Rethinking the residual approach: Leveraging machine learning to operationalize cognitive resilience in Alzheimer’s disease
Rethinking the residual approach: Leveraging machine learning to operationalize cognitive resilience in Alzheimer’s disease Open
Cognitive resilience describes the phenomenon of individuals evading cognitive decline despite prominent Alzheimer’s disease neuropathology. Operationalization and measurement of this latent construct is non-trivial as it cannot be directl…
View article: Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration
Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration Open
View article: Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease
Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease Open
View article: Greater White Matter Hyperintensity Volume Is Associated with the Number of Microhemorrhages in Preclinical Alzheimer's Disease
Greater White Matter Hyperintensity Volume Is Associated with the Number of Microhemorrhages in Preclinical Alzheimer's Disease Open
These results indicate a strong association between WMH and MCH, a common manifestation of cerebral amyloid angiopathy and ARIA-H. These results suggest that increased WMH volume may represent an early sign of vessel amyloidosis, likely pr…
View article: Amyloid and tau burden relate to longitudinal changes in the performance of complex everyday activities among cognitively unimpaired older adults: results from the performance-based Harvard Automated Phone Task
Amyloid and tau burden relate to longitudinal changes in the performance of complex everyday activities among cognitively unimpaired older adults: results from the performance-based Harvard Automated Phone Task Open
Background Changes in everyday functioning constitute a clinically meaningful outcome, even in the early stages of Alzheimer's disease. Performance-based assessments of everyday functioning might help uncover these early changes. We aimed …
View article: Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases
Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases Open
In LBD, volume loss in hippocampal output subregions-particularly the subiculum-is associated with functional cognition and AD-related deposits. Tau deposition appears to accelerate subiculum and CA1 atrophy, whereas Aβ does not. Subiculum…
View article: Longitudinal associations of apathy and regional tau in mild cognitive impairment and dementia: Findings from the Alzheimer's Disease Neuroimaging Initiative
Longitudinal associations of apathy and regional tau in mild cognitive impairment and dementia: Findings from the Alzheimer's Disease Neuroimaging Initiative Open
Introduction It is important to study apathy in Alzheimer's disease (AD) to better understand its underlying neurobiology and develop effective interventions. In the current study, we sought to examine the relationships between longitudina…
View article: Associations among depressive symptoms, hippocampal volume and cognition in community‐dwelling older Latinos
Associations among depressive symptoms, hippocampal volume and cognition in community‐dwelling older Latinos Open
Background Latinos are the fastest growing subpopulation of older adults in the U.S. and have a higher risk for dementia than non‐Latino Whites. Depressive symptoms are prevalent among US Latinos. However, these symptoms often go undiagnos…
View article: Estimating a clinically normal individual’s position along a preclinical Alzheimer’s disease continuum using cognitive and amyloid trajectories
Estimating a clinically normal individual’s position along a preclinical Alzheimer’s disease continuum using cognitive and amyloid trajectories Open
Background Optimizing longitudinal cognitive and biomarker trajectories can distill multiple observations from one individual into a single metric. Relative to other individuals, this metric can represent an individual’s distance from an a…
View article: Preliminary evaluation of the digital maze test in relation to neuropsychological tests and AD biomarkers
Preliminary evaluation of the digital maze test in relation to neuropsychological tests and AD biomarkers Open
Background Digital cognitive tools may provide unique opportunities to detect subtle changes in preclinical Alzheimer’s disease (AD). Here, a maze test using a digital pen was evaluated in relation to AD pathological changes measured by am…
View article: Systemic vascular risk, white matter injury, and relative cerebral blood flow independently contribute to cognitive decline beyond amyloid and tau burden
Systemic vascular risk, white matter injury, and relative cerebral blood flow independently contribute to cognitive decline beyond amyloid and tau burden Open
Background Age, systemic vascular risk factors, white matter injury, cerebral blood flow, amyloid, and tau burden are well‐established contributors to late‐life cognitive decline. Given the strong relationship among these measures, we prop…