Michael J. Raphael
YOU?
Author Swipe
View article: Recommendations for studying the association of the cancer diagnosis to treatment interval with overall survival: a modified Delphi process
Recommendations for studying the association of the cancer diagnosis to treatment interval with overall survival: a modified Delphi process Open
Providing valid evidence of the DTI effect on OS requires careful approaches. This paper offers recommendations on how to improve methodological quality. This will ensure that future studies effectively contribute to evidence-informed prac…
View article: Prioritizing the Timely Detection and Diagnosis of Early-Age Onset Cancer to Enable Optimal Disease Management and Outcomes
Prioritizing the Timely Detection and Diagnosis of Early-Age Onset Cancer to Enable Optimal Disease Management and Outcomes Open
In November 2024, the fourth annual Symposium focusing on early-age onset cancer (EAOC) was hosted by the Colorectal Cancer Resource & Action Network (CCRAN), assembling clinicians, researchers, and patients virtually to discuss challenges…
View article: Focused ultrasound and concurrent chemotherapy for the treatment of advanced pancreatic cancer: A systematic review
Focused ultrasound and concurrent chemotherapy for the treatment of advanced pancreatic cancer: A systematic review Open
Background and Objectives The combination of focused ultrasound (FUS) and chemotherapy is a novel treatment for pancreatic cancer. This paper reviews the literature on this combined therapy. Methods The medical literature was searched acco…
View article: Addressing the Rising Trend in Early-Age-Onset Cancers in Canada
Addressing the Rising Trend in Early-Age-Onset Cancers in Canada Open
A multi-disciplinary symposium on early-age onset cancer (EAOC) was held in October 2023 to explore challenges experienced by this rapidly growing population. A major outcome of the symposium was recognition of the remarkable similarities …
View article: Barriers and Unequal Access to Timely Molecular Testing Results: Addressing the Inequities in Cancer Care Delays across Canada
Barriers and Unequal Access to Timely Molecular Testing Results: Addressing the Inequities in Cancer Care Delays across Canada Open
Genomic medicine is a powerful tool to improve diagnosis and outcomes for cancer patients by facilitating the delivery of the right drug at the right dose at the right time for the right patient. In 2023, a Canadian conference brought toge…
View article: Breaking Down Barriers to Detection and Care in Early-Age-Onset Colorectal Cancer in Canada
Breaking Down Barriers to Detection and Care in Early-Age-Onset Colorectal Cancer in Canada Open
The second Early-Age-Onset Colorectal Cancer Symposium, convened in October 2022, sought solutions to the barriers to early detection and care for colorectal cancer in Canada. This meeting built on a previous symposium, held in 2021 and re…
View article: Do female and male patients derive similar benefits from approved systemic oncology therapies? A systematic review and meta-analysis
Do female and male patients derive similar benefits from approved systemic oncology therapies? A systematic review and meta-analysis Open
View article: Comparison of Use of Neoadjuvant Systemic Treatment for Breast Cancer and Short-term Outcomes Before vs During the COVID-19 Era in Ontario, Canada
Comparison of Use of Neoadjuvant Systemic Treatment for Breast Cancer and Short-term Outcomes Before vs During the COVID-19 Era in Ontario, Canada Open
In this cohort study, patients were more likely to start neoadjuvant ST in the COVID-19 era, which varied across the province and by indication. There was limited evidence to suggest any substantial impact on short-term outcomes.
View article: Real-World Cost-Effectiveness of First-Line Gemcitabine Plus Nab-Paclitaxel vs FOLFIRINOX in Patients With Advanced Pancreatic Cancer
Real-World Cost-Effectiveness of First-Line Gemcitabine Plus Nab-Paclitaxel vs FOLFIRINOX in Patients With Advanced Pancreatic Cancer Open
Background There are no randomized control trials (RCTs) comparing gemcitabine and nab-paclitaxel (Gem-Nab) and fluorouracil, folinic acid, irinotecan, oxaliplatin (FOLFIRINOX) for advanced pancreatic cancer (APC). Although it is well know…
View article: An Evaluation of Sex- and Gender-Based Analyses in Oncology Clinical Trials
An Evaluation of Sex- and Gender-Based Analyses in Oncology Clinical Trials Open
Background The objective of this study was to evaluate whether sex- and gender-based analyses and proper sex and gender terminology were used in oncology trials leading to regulatory drug approval. Methods The Food and Drug Administration …
View article: Small Particle DEBIRI TACE as Salvage Therapy in Patients with Liver Dominant Colorectal Cancer Metastasis: Retrospective Analysis of Safety and Outcomes
Small Particle DEBIRI TACE as Salvage Therapy in Patients with Liver Dominant Colorectal Cancer Metastasis: Retrospective Analysis of Safety and Outcomes Open
The aim of this study was to examine the safety and efficacy of 40 µm and 75 µm calibrated irinotecan-eluting beads (DEBIRI-TACE) for the treatment of colorectal cancer metastases. We conducted a retrospective review of 36 patients with un…
View article: The Association of Drug-Funding Reimbursement With Survival Outcomes and Use of New Systemic Therapies Among Patients With Advanced Pancreatic Cancer
The Association of Drug-Funding Reimbursement With Survival Outcomes and Use of New Systemic Therapies Among Patients With Advanced Pancreatic Cancer Open
This cohort study of patients with advanced pancreatic cancer receiving first-line palliative chemotherapy within a universal health care system found that drug funding decisions were associated with increased uptake of new treatment optio…
View article: Mental Health Resource Use Among Patients Undergoing Curative Intent Treatment for Bladder Cancer
Mental Health Resource Use Among Patients Undergoing Curative Intent Treatment for Bladder Cancer Open
Background Patients with bladder cancer may experience mental health distress. Mental health-care service (MHS) use can quantify the magnitude of the problem. Methods The Ontario Cancer Registry was used to identify all patients with bladd…
View article: A Population-Based Study of Pulmonary Monitoring and Toxicity for Patients with Testicular Cancer Treated with Bleomycin
A Population-Based Study of Pulmonary Monitoring and Toxicity for Patients with Testicular Cancer Treated with Bleomycin Open
Background：Bleomycin is commonly used to treat advanced testicular cancer and can be associated with severe pulmonary toxicity. The primary objective of the present study was to describe the use of pulmonary function tests (PFTs) and chest…
View article: Association between Waiting Time for Radiotherapy after Surgery for Early-Stage Breast Cancer and Survival Outcomes in Ontario: A Population-Based Outcomes Study
Association between Waiting Time for Radiotherapy after Surgery for Early-Stage Breast Cancer and Survival Outcomes in Ontario: A Population-Based Outcomes Study Open
Background: After surgery for early-stage breast cancer (bca), adjuvant radiotherapy (rt) decreases the risk of locoregional recurrence and death from bca. It is unclear whether delays to the initiation of adjuvant rt are associated with i…
View article: Factors Associated With Chemoradiation Therapy Interruption and Noncompletion Among Patients With Squamous Cell Anal Carcinoma
Factors Associated With Chemoradiation Therapy Interruption and Noncompletion Among Patients With Squamous Cell Anal Carcinoma Open
Many patients undergoing curative-intent chemoradiation for anal cancer experienced treatment interruption or noncompletion. Quality improvement initiatives to optimize treatment continuity and completion are needed.
View article: Would Regionalization of Systemic Cancer Therapy Improve the Quality of Cancer Care?
Would Regionalization of Systemic Cancer Therapy Improve the Quality of Cancer Care? Open
View article: Neurotoxicity Among Survivors of Testicular Cancer: A Population-based Study
Neurotoxicity Among Survivors of Testicular Cancer: A Population-based Study Open
View article: Neoadjuvant chemotherapy for muscle-invasive bladder cancer: Underused across the 49th parallel
Neoadjuvant chemotherapy for muscle-invasive bladder cancer: Underused across the 49th parallel Open
View article: Anxiety, Depression and Quality of Life Improve After One Month and Three Months of Home Parenteral Nutrition: A Pilot Study in a Canadian Population
Anxiety, Depression and Quality of Life Improve After One Month and Three Months of Home Parenteral Nutrition: A Pilot Study in a Canadian Population Open
Background Patients receiving home parenteral nutrition (HPN) have a reduced quality of life (QoL), but it is unknown if this is associated with psychiatric comorbidities such as anxiety or depression. Aim The aim of this study was to asse…
View article: McKittrick–Wheelock syndrome
McKittrick–Wheelock syndrome Open
A58-year-old woman presented to the emergency department. She had been vomiting and feeling confused for three days, and she had fallen several times. Three months before her presentation, the patient had been admitted to the intensive car…
View article: A Virtual Ward for Home Hemodialysis Patients – A Pilot Trial
A Virtual Ward for Home Hemodialysis Patients – A Pilot Trial Open
Background: Patients with end-stage renal disease (ESRD) have a high rate of hospitalization and are prone to care gaps that may occur during the transition from hospital to home. The virtual ward (VW) is an innovative model that provides …