Michael Wolf
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View article: Thyroid hormone receptor beta signaling is a targetable driver of prostate cancer growth
Thyroid hormone receptor beta signaling is a targetable driver of prostate cancer growth Open
Thyroid hormone (TH) signaling plays a major role in the development, energy homeostasis, and metabolism of most tissues. Recent studies have identified THs as drivers of prostate cancer (PCa) development and progression. We reported that …
View article: Eccrine sweat reveals normalization of artificial sweetener levels in children with overweight after nutritional education
Eccrine sweat reveals normalization of artificial sweetener levels in children with overweight after nutritional education Open
Determining metabolic parameters associated with childhood obesity is challenging due to the invasive nature of most sampling methods. Using a non-invasive eccrine sweat collection, 134 metabolomes were obtained from 54 children, of which …
View article: Analysis of Postmortem Dermal Extracts is an Efficient Illicit Drug Screening Method Supporting Forensic Medicine
Analysis of Postmortem Dermal Extracts is an Efficient Illicit Drug Screening Method Supporting Forensic Medicine Open
The forensic screening of illicit drugs usually depends on analyzing tissue homogenates, which is resource-intensive. Exploring a non-invasive sampling method using dermal extracts collected postmortem, we developed a rapid technique to an…
View article: Gendered burial practices in Copper Age non-adults of Iberia: Evidence from peptide-based sex identification at Humanejos (Madrid, Spain)
Gendered burial practices in Copper Age non-adults of Iberia: Evidence from peptide-based sex identification at Humanejos (Madrid, Spain) Open
View article: Proteomic Analysis of FFPE Tissue Samples Identifies Potential Molecular Mechanisms Mediating Resistance to Radiotherapy in Rectal Cancer
Proteomic Analysis of FFPE Tissue Samples Identifies Potential Molecular Mechanisms Mediating Resistance to Radiotherapy in Rectal Cancer Open
Chemoradiation prior to surgery in locally advanced rectal cancer is the current standard therapy but is not effective in all rectal cancer patients. Prognostic markers supporting patient stratification with respect to clinical response wo…
View article: P428: Metabolomics, Lipidomics and Proteomics of breast cancer patients during their first cycle of chemotherapy
P428: Metabolomics, Lipidomics and Proteomics of breast cancer patients during their first cycle of chemotherapy Open
View article: Mass spectrometry-based analysis of eccrine sweat supports predictive, preventive and personalised medicine in a cohort of breast cancer patients in Austria
Mass spectrometry-based analysis of eccrine sweat supports predictive, preventive and personalised medicine in a cohort of breast cancer patients in Austria Open
Objective Metabolomics measurements of eccrine sweat may provide novel and relevant biomedical information to support predictive, preventive and personalised medicine (3PM). However, only limited data is available regarding metabolic alter…
View article: Frontmatter
Frontmatter Open
View article: Effects of carbonation of liquids on penetration–aspiration and residue management
Effects of carbonation of liquids on penetration–aspiration and residue management Open
View article: Frontmatter
Frontmatter Open
View article: Optical analysis of facial nerve degeneration in Bell’s palsy
Optical analysis of facial nerve degeneration in Bell’s palsy Open
This paper is an initial proof of concept for an optical speckled-based method for the evaluation of facial nerve paralysis. Differences between the affected and the healthy sides of the face were measured in patients with Bell's palsy—a p…
View article: Human Nasal Turbinate Tissues in Organ Culture as a Model for Human Cytomegalovirus Infection at the Mucosal Entry Site
Human Nasal Turbinate Tissues in Organ Culture as a Model for Human Cytomegalovirus Infection at the Mucosal Entry Site Open
HCMV is a ubiquitous human pathogen causing neurodevelopmental disabilities in congenitally infected children and severe disease in immunocompromised patients. The earliest stages of HCMV infection in the human host have remained elusive i…
View article: Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene <scp> <i>ATOH1</i> </scp>
Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene <span> <i>ATOH1</i> </span> Open
Mutations in more than 150 genes are responsible for inherited hearing loss, with thousands of different, severe causal alleles that vary among populations. The Israeli Jewish population includes communities of diverse geographic origins, …
View article: Non-contact optical sensing of vocal fold vibrations by secondary speckle patterns
Non-contact optical sensing of vocal fold vibrations by secondary speckle patterns Open
Vocal folds lesions are commonly diagnosed using an endoscopic-stroboscope. However, the stroboscopic picture of the vocal folds vibrations is subjectively and qualitatively evaluated by the clinician and, due to technical limitations, is …
View article: Evoluation and technological advances in ablation of complex atrial and ventricular arrhythmias
Evoluation and technological advances in ablation of complex atrial and ventricular arrhythmias Open
An ablation is a treatment procedure in which disruptive electrical stimuli to the heart are blocked or disorders in electrical conduction by the heart muscle tissue are remedied. These ablations are carried out increasingly often, as due …
View article: Starke Mitbestimmung, stabile Unternehmen: Eine empirische Analyse vor dem Hintergrund der Finanz- und Wirtschaftskrise
Starke Mitbestimmung, stabile Unternehmen: Eine empirische Analyse vor dem Hintergrund der Finanz- und Wirtschaftskrise Open
Dieser Mitbestimmungsreport ist eine Kurzdarstellung eines von der Hans-Böckler-Stiftung geförderten Projekts mit dem Titel: Wirkung der Mitbestimmung im Aufsichtsrat auf die Unternehmensführung. Hier wurde die Rolle der unternehmerischen …
View article: Strong codetermination - stable companies: An empirical analysis in lights of the recent financial crisis
Strong codetermination - stable companies: An empirical analysis in lights of the recent financial crisis Open
This Mitbestimmungsreport is a brief presentation of a project supported by the Hans-Böckler-Stiftung, entitled 'The effects of codetermination in the supervisory board on corporate governance'. The object of study was the role of company …
View article: Remote optical sensing in otolaryngology: middle ear effusion detection
Remote optical sensing in otolaryngology: middle ear effusion detection Open
Otitis Media (OM) is related to a group of inflammatory diseases of the middle ear (ME) commonly encountered, worldwide. A method based on a simple device, which can be used by medical staff and non-experts to detect OM is presented. The m…
View article: The significance of Computed Tomography in invasive paranasal mucormycosis
The significance of Computed Tomography in invasive paranasal mucormycosis Open
Bony erosion on paranasal CT is an exceptionally insensitive radiologic sign for establishing or rejecting the diagnosis of Mucor induced AIFR. The mainstay of confirming or rejecting the diagnosis of AIFR is by physical examination, endos…
View article: Mobile phone usage does not affect sudden sensorineural hearing loss
Mobile phone usage does not affect sudden sensorineural hearing loss Open
Objective: Recent studies found that mobile phone users had a significantly greater risk of having elevated thresholds in speech frequencies. This study investigated the correlation between the laterality of sudden sensorineural hearing lo…
View article: Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia
Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia Open
Despite extensive efforts, half of patients with rare movement disorders such as hereditary spastic paraplegias and cerebellar ataxias remain genetically unexplained, implicating novel genes and unrecognized mutations in known genes. Non-c…
View article: TLR4 deficiency prevents a hyperinflammatory cytokine response upon second-hit virulence factor stimulation.
TLR4 deficiency prevents a hyperinflammatory cytokine response upon second-hit virulence factor stimulation. Open
Cytokine mRNA measurements upon LTA (A) or CpG-ODN (B) challenges overall demonstrated a pronounced increase in TAC wild type mice. Cytokine levels upon second-hit treatment did not differ between sham and TAC Tlr4-/-
View article: PRR mRNA expression in wild type mice after 3 d of TAC and 6 h of LTA or CpG-ODN 1668 thioate stimulation.
PRR mRNA expression in wild type mice after 3 d of TAC and 6 h of LTA or CpG-ODN 1668 thioate stimulation. Open
* p < 0.05 between TAC LTA and indicated groups, n = 5-6/groupPRR mRNA expression in wild type mice after 3 d of TAC and 6 h of LTA or CpG-ODN 1668 thioate stimulation.
View article: LTA affected the hemodynamic function of TAC operated wild type mice.
LTA affected the hemodynamic function of TAC operated wild type mice. Open
3 d of pressure overload increased the left ventricular systolic pressure (A) and mean arterial blood pressure (B) of wild type mice (p<0.001, mean ± SEM, n = 7-13/group). LTA did not cause cardiac depression 6 h after stimulation in sham …
View article: Cardiac function of TAC operated Tlr4<sup>-/-</sup> mice is not altered after LTA or CpG-ODN stimulation.
Cardiac function of TAC operated Tlr4<sup>-/-</sup> mice is not altered after LTA or CpG-ODN stimulation. Open
(A) Reduced left ventricular hypertrophy in female TLR4-deficient mice was confirmed after 3 d of pressure overload (*p<0.05, **p<0.01, ***p<0.001, n = 7–13). In line with this, left ventricular systolic pressure was reduced in PBS TAC …
View article: TaqMan® gene expression assays used for real-time PCR. (TaqMan® Gene Expression Assay, Applied Biosystems).
TaqMan® gene expression assays used for real-time PCR. (TaqMan® Gene Expression Assay, Applied Biosystems). Open
TaqMan® gene expression assays used for real-time PCR. (TaqMan® Gene Expression Assay, Applied Biosystems).
View article: Cytokine mRNA expression in wild type mice after 3 d of TAC and 6 h of LTA or CpG-ODN 1668 thioate stimulation.
Cytokine mRNA expression in wild type mice after 3 d of TAC and 6 h of LTA or CpG-ODN 1668 thioate stimulation. Open
Significant differences between relevant groups are indicated by identical superscripted letters (p < 0.05), n = 5-6/group.a: sham PBS vs. sham LTAb: sham LTA vs. TAC LTAc: sham CpG vs. TAC CpGd: TAC PBS vs. TAC LTAe: TAC PBS vs. TAC CpG.C…
View article: <i>Differential influence of LTA second-hit treatment on PRR expression in Tlr4</i><sup><i>-/-</i></sup> mice.
<i>Differential influence of LTA second-hit treatment on PRR expression in Tlr4</i><sup><i>-/-</i></sup> mice. Open
Consecutive LTA stimulation provokes a significant elevation of TLR-1, -2, -6 and CD14 in TAC wild type compared to sham wild type mice. An exclusive upregulation of TLR2 mRNA expression was observed in TAC Tlr4-/-…
View article: PRR mRNA expression in <i>Tlr4</i><sup><i>-/-</i></sup> mice after 3 d of TAC and 6 h of CpG-ODN 1668-thioate stimulation.
PRR mRNA expression in <i>Tlr4</i><sup><i>-/-</i></sup> mice after 3 d of TAC and 6 h of CpG-ODN 1668-thioate stimulation. Open
n = 5-6/groupPRR mRNA expression in Tlr4-/- mice after 3 d of TAC and 6 h of CpG-ODN 1668-thioate stimulation.
View article: CpG-ODN second-hit challenge of wild type mice has no impact on cardiac function.
CpG-ODN second-hit challenge of wild type mice has no impact on cardiac function. Open
(A) TAC altered left ventricular systolic pressure (***p<0.001) whereas CpG-ODN stimulation had no influence. (B) Heart rate was only moderately increased after TAC or CpG-ODN challenge (n = 10-14/group).