Michael-John Dolan
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View article: Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration
Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration Open
Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characterized. Here, we combined optimized single…
View article: Author response: A split-GAL4 driver line resource for Drosophila neuron types
Author response: A split-GAL4 driver line resource for Drosophila neuron types Open
View article: A split-GAL4 driver line resource for Drosophila neuron types
A split-GAL4 driver line resource for Drosophila neuron types Open
Techniques that enable precise manipulations of subsets of neurons in the fly central nervous system (CNS) have greatly facilitated our understanding of the neural basis of behavior. Split-GAL4 driver lines allow specific targeting of cell…
View article: Author response: A split-GAL4 driver line resource for Drosophila neuron types
Author response: A split-GAL4 driver line resource for Drosophila neuron types Open
View article: A split-GAL4 driver line resource for Drosophila neuron types
A split-GAL4 driver line resource for Drosophila neuron types Open
Techniques that enable precise manipulations of subsets of neurons in the fly central nervous system have greatly facilitated our understanding of the neural basis of behavior. Split-GAL4 driver lines allow specific targeting of cell types…
View article: HiDDEN: a machine learning method for detection of disease-relevant populations in case-control single-cell transcriptomics data
HiDDEN: a machine learning method for detection of disease-relevant populations in case-control single-cell transcriptomics data Open
View article: Author response: A split-GAL4 driver line resource for Drosophila CNS cell types
Author response: A split-GAL4 driver line resource for Drosophila CNS cell types Open
Techniques that enable precise manipulations of subsets of neurons in the fly central nervous system have greatly facilitated our understanding of the neural basis of behavior. Split-GAL4 driver lines allow specific targeting of cell types…
View article: A split-GAL4 driver line resource for Drosophila neuron types
A split-GAL4 driver line resource for Drosophila neuron types Open
Techniques that enable precise manipulations of subsets of neurons in the fly central nervous system (CNS) have greatly facilitated our understanding of the neural basis of behavior. Split-GAL4 driver lines allow specific targeting of cell…
View article: A split-GAL4 driver line resource for Drosophila CNS cell types
A split-GAL4 driver line resource for Drosophila CNS cell types Open
Techniques that enable precise manipulations of subsets of neurons in the fly central nervous system have greatly facilitated our understanding of the neural basis of behavior. Split-GAL4 driver lines allow specific targeting of cell types…
View article: A split-GAL4 driver line resource for <i>Drosophila</i> neuron types
A split-GAL4 driver line resource for <i>Drosophila</i> neuron types Open
Techniques that enable precise manipulations of subsets of neurons in the fly central nervous system have greatly facilitated our understanding of the neural basis of behavior. Split-GAL4 driver lines allow specific targeting of cell types…
View article: A toolkit to study microglia states using stem cell‐derived models
A toolkit to study microglia states using stem cell‐derived models Open
Background Emerging genetic studies of late‐onset Alzheimer’s Disease (LOAD) implicate microglia, the brain’s resident macrophages. More than half the risk genes associated with LOAD are expressed in microglia, yet we know little about the…
View article: Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro Open
Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative diseases such as Alzheimer’s disease. These cells adopt distinct transcriptional subtypes known as states. Understanding state function, especially in…
View article: HiDDEN: A machine learning label refinement method for detection of disease-relevant populations in case-control single-cell transcriptomics
HiDDEN: A machine learning label refinement method for detection of disease-relevant populations in case-control single-cell transcriptomics Open
In case-control single-cell RNA-seq studies, sample-level labels are transferred onto individual cells, labeling all case cells as affected, but only a small fraction of them may actually be perturbed. Here, using simulations, we demonstra…
View article: A resource for generating and manipulating human microglial states in vitro
A resource for generating and manipulating human microglial states in vitro Open
Microglia have emerged as key players in the pathogenesis of neurodegenerative conditions such as Alzheimer’s disease (AD). In response to CNS stimuli, these cells adopt distinct transcriptional and functional subtypes known as states. How…
View article: Cell types and neuronal circuitry underlying female aggression in Drosophila
Cell types and neuronal circuitry underlying female aggression in Drosophila Open
Aggressive social interactions are used to compete for limited resources and are regulated by complex sensory cues and the organism’s internal state. While both sexes exhibit aggression, its neuronal underpinnings are understudied in femal…
View article: Author response: Cell types and neuronal circuitry underlying female aggression in Drosophila
Author response: Cell types and neuronal circuitry underlying female aggression in Drosophila Open
View article: Neuronal circuitry underlying female aggression in<i>Drosophila</i>
Neuronal circuitry underlying female aggression in<i>Drosophila</i> Open
Aggressive social interactions are used to compete for limited resources and are regulated by complex sensory cues and the organism’s internal state. While both sexes exhibit aggression, its neuronal underpinnings are understudied in femal…
View article: Percentage contribution of reference recipes to Food Groups for Irish and UK Food Based Dietary Guidelines.
Percentage contribution of reference recipes to Food Groups for Irish and UK Food Based Dietary Guidelines. Open
Food Based Dietary Guidelines (FBDG) are a set of recommendations that describe the quantity and types of foods to consume to promote healthy eating and prevent diseases such as obesity. However, when assessing compliance with FBDG, calcul…
View article: Food Based Dietary Guidance - Weighing up the recommendations
Food Based Dietary Guidance - Weighing up the recommendations Open
Food Based Dietary Guidelines (FBDG) are dietary recommendations described in terms of amounts of foods that should be consumed. They are designed to support healthy eating through simple messaging and indicate how to achieve a nutritional…
View article: Functional and anatomical specificity in a higher olfactory centre
Functional and anatomical specificity in a higher olfactory centre Open
Most sensory systems are organized into parallel neuronal pathways that process distinct aspects of incoming stimuli. In the insect olfactory system, second order projection neurons target both the mushroom body, required for learning, and…
View article: Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body
Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body Open
Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In Drosophila, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional unders…
View article: Author response: Functional and anatomical specificity in a higher olfactory centre
Author response: Functional and anatomical specificity in a higher olfactory centre Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Most sensory systems are organized into pa…
View article: Author response: Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body
Author response: Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Animals exhibit innate behaviours to a var…
View article: Communication from Learned to Innate Olfactory Processing Centers Is Required for Memory Retrieval in Drosophila
Communication from Learned to Innate Olfactory Processing Centers Is Required for Memory Retrieval in Drosophila Open
View article: Neurogenetic dissection of the <i>Drosophila</i> innate olfactory processing center
Neurogenetic dissection of the <i>Drosophila</i> innate olfactory processing center Open
Animals exhibit innate behaviours in response to a variety of sensory stimuli such as olfactory cues. In Drosophila , a higher olfactory centre called the lateral horn (LH) is implicated in innate behaviour. However, our knowledge of the s…
View article: Neural circuit basis of aversive odour processing in <i>Drosophila</i> from sensory input to descending output
Neural circuit basis of aversive odour processing in <i>Drosophila</i> from sensory input to descending output Open
Evolution has shaped nervous systems to produce stereotyped behavioural responses to ethologically relevant stimuli. For example when laying eggs, female Drosophila avoid geosmin, an odorant produced by toxic moulds. Here we identify secon…
View article: Functional and Anatomical Specificity in a Higher Olfactory Centre
Functional and Anatomical Specificity in a Higher Olfactory Centre Open
Most sensory systems are organized into parallel neuronal pathways that process distinct aspects of incoming stimuli. For example, in insects, second order olfactory projection neurons target both the mushroom body, which is required for l…
View article: Communication from learned to innate olfactory processing centers is required for memory retrieval in<i>Drosophila</i>
Communication from learned to innate olfactory processing centers is required for memory retrieval in<i>Drosophila</i> Open
Animals can show either learned or innate behavioral responses to a given stimulus. How these circuits interact to produce an appropriate behavioral response is unknown. In the Drosophila olfactory system, the lateral horn (LH) and the mus…
View article: Facilitating Neuron-Specific Genetic Manipulations in <i>Drosophila melanogaster</i> Using a Split GAL4 Repressor
Facilitating Neuron-Specific Genetic Manipulations in <i>Drosophila melanogaster</i> Using a Split GAL4 Repressor Open
Efforts to map neural circuits have been galvanized by the development of genetic technologies that permit the manipulation of targeted sets of neurons in the brains of freely behaving animals. The success of these efforts relies on the ex…
View article: Insect Olfaction: Telling Food from Foe
Insect Olfaction: Telling Food from Foe Open