Michael Jonsson
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View article: No association between markers of systemic inflammation and endothelial dysfunction with Alzheimer’s disease progression: a longitudinal study
No association between markers of systemic inflammation and endothelial dysfunction with Alzheimer’s disease progression: a longitudinal study Open
Introduction Systemic inflammation and endothelial dysfunction are potentially modifiable factors implicated in Alzheimer’s disease (AD), which offer potential therapeutic targets to slow disease progression. Methods We investigated the re…
View article: Swedish intelligence, Russia and the war in Ukraine: anticipations, course, and future implications
Swedish intelligence, Russia and the war in Ukraine: anticipations, course, and future implications Open
As the sole plausible military threat facing Sweden, the Soviet Union and then Russia have consistently been at the top of Swedish intelligence collection priorities. In fact, understanding Russia and its military forces well is a source o…
View article: Baseline levels of soluble amyloid precursor proteins predict conversion to subcortical small-vessel disease
Baseline levels of soluble amyloid precursor proteins predict conversion to subcortical small-vessel disease Open
Introduction: The Gothenburg Mild Cognitive Impairment (MCI) study is a longitudinal mono-center study of patients seeking help for cognitive complaints at the memory clinic in Gothenburg, Sweden. The study includes both pre-clinical diagn…
View article: Author Correction: Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial
Author Correction: Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial Open
Correction to: Nature Medicine. Published online 24 April 2023. In the version of this article initially published, the affiliation for Daniel Blackburn was incomplete and has been amended to read “Sheffield Teaching Hospital NHS Foundatio…
View article: Espionage by Europeans: treason and counterintelligence in post-Cold War Europe
Espionage by Europeans: treason and counterintelligence in post-Cold War Europe Open
As war rages in Ukraine, counterintelligence has again taken centre stage for European intelligence agencies. In spite of the long-ascendant espionage threat, to date little is known about who is recruited, what motivated them and how they…
View article: Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial Open
Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT expression with a tau-targeting antisense oligonucleotide (MAPT Rx …
View article: Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease
Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease Open
ClinicalTrials.gov Identifier: NCT03289143.
View article: Blood‐brain barrier dysfunction and reduced cerebrospinal fluid levels of soluble amyloid precursor protein‐β in patients with subcortical small‐vessel disease
Blood‐brain barrier dysfunction and reduced cerebrospinal fluid levels of soluble amyloid precursor protein‐β in patients with subcortical small‐vessel disease Open
Introduction Subcortical small‐vessel disease (SSVD) is the most common vascular cognitive disorder. However, because no disease‐specific cerebrospinal fluid (CSF) biomarkers are available for SSVD, our aim was to identify such markers. Me…
View article: Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders
Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders Open
Introduction To evaluate the usefulness of the 2018 NIA‐AA (National Institute on Aging and Alzheimer's Association) research framework in a longitudinal memory clinic study with different clinical outcomes and underlying disorders. Method…
View article: Characteristic Biomarker and Cognitive Profile in Incipient Mixed Dementia
Characteristic Biomarker and Cognitive Profile in Incipient Mixed Dementia Open
Background: Research has shown that mixed dementia is more common than previously believed but little is known of its early stages. Objective: To examine if incipient mixed dementia can be differentiated from incipient Alzheimer’s disease …
View article: Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology
Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology Open
These data support the use of cNfL as a biomarker of neuroaxonal damage and indicate that age-specific and sex-specific (and in some cases disease-specific) reference values may be needed. The cNfL has potential to assist the differentiati…
View article: Blood Pressure Lowering With Nilvadipine in Patients With Mild‐to‐Moderate Alzheimer Disease Does Not Increase the Prevalence of Orthostatic Hypotension
Blood Pressure Lowering With Nilvadipine in Patients With Mild‐to‐Moderate Alzheimer Disease Does Not Increase the Prevalence of Orthostatic Hypotension Open
Background Hypertension is common among patients with Alzheimer disease. Because this group has been excluded from hypertension trials, evidence regarding safety of treatment is lacking. This secondary analysis of a randomized controlled t…
View article: Consensus guidelines for lumbar puncture in patients with neurological diseases
Consensus guidelines for lumbar puncture in patients with neurological diseases Open
Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines…
View article: Longitudinal evaluation of criteria for subjective cognitive decline and preclinical Alzheimer's disease in a memory clinic sample
Longitudinal evaluation of criteria for subjective cognitive decline and preclinical Alzheimer's disease in a memory clinic sample Open
Introduction Subjective cognitive decline (SCD) and biomarker‐based “at‐risk” concepts such as “preclinical” Alzheimer's disease (AD) have been developed to predict AD dementia before objective cognitive impairment is detectable. We longit…
View article: Alzheimer’s disease—subcortical vascular disease spectrum in a hospital-based setting: Overview of results from the Gothenburg MCI and dementia studies
Alzheimer’s disease—subcortical vascular disease spectrum in a hospital-based setting: Overview of results from the Gothenburg MCI and dementia studies Open
The ability to discriminate between Alzheimer’s disease (AD), subcortical vascular disease, and other cognitive disorders is crucial for diagnostic purposes and clinical trial outcomes. Patients with primarily subcortical vascular disease …
View article: The Gothenburg MCI study: Design and distribution of Alzheimer’s disease and subcortical vascular disease diagnoses from baseline to 6-year follow-up
The Gothenburg MCI study: Design and distribution of Alzheimer’s disease and subcortical vascular disease diagnoses from baseline to 6-year follow-up Open
There is a need for increased nosological knowledge to enable rational trials in Alzheimer’s disease (AD) and related disorders. The ongoing Gothenburg mild cognitive impairment (MCI) study is an attempt to conduct longitudinal in-depth ph…