Michael Julius
YOU?
Author Swipe
View article: The Glycosylphosphatidylinositol Anchor Regulates T Cell Antigen Receptor Induced IL-2 Production
The Glycosylphosphatidylinositol Anchor Regulates T Cell Antigen Receptor Induced IL-2 Production Open
Differential contributions of the glycosylphosphatidylinositol (GPI)-anchor and GPI-anchored proteins (GPI-AP) to signalling remain poorly understood. Here we show that GPI-AP deficient murine clones produce on average 18 and 181-fold more…
View article: VISTA.COMP — an engineered checkpoint receptor agonist that potently suppresses T cell–mediated immune responses
VISTA.COMP — an engineered checkpoint receptor agonist that potently suppresses T cell–mediated immune responses Open
V-domain immunoglobulin suppressor of T cell activation (VISTA) is a recently discovered immune checkpoint ligand that functions to suppress T cell activity. The therapeutic potential of activating this immune checkpoint pathway to reduce …
View article: Fyn Expression Predicates Both Protective Immunity and Onset of Autoimmunity
Fyn Expression Predicates Both Protective Immunity and Onset of Autoimmunity Open
Genomic disruption of Fyn has not been associated with an immune-deficient phenotype, notwithstanding the profound impairment in IL-2 production by T cells derived from Fyn-deficient animals observed in vitro. The results presented demonst…