Michael Fink
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View article: Early Change in C-Reactive Protein and Venous Thromboembolism in Patients Treated With Immune Checkpoint Inhibitors
Early Change in C-Reactive Protein and Venous Thromboembolism in Patients Treated With Immune Checkpoint Inhibitors Open
Early CRP changes during ICI therapy are associated with an increased risk of VTE, suggesting a potential association between ICI-induced inflammation and hypercoagulability. CRP trajectories may serve as a biomarker for ICI-associated VTE.
View article: A Clinical Scoring System and Impact of Athymic Nude Mouse Age on Corynebacterium bovis Clinical Disease
A Clinical Scoring System and Impact of Athymic Nude Mouse Age on Corynebacterium bovis Clinical Disease Open
Corynebacterium bovis infection in biomedical research is synonymous with skin hyperkeratosis of athymic nude mice. This clinical sign can be obvious and is the namesake for ‘scaly skin disease.’ Other clinical signs that accompany scaly s…
View article: A Clinical Scoring Systems for the Evaluation of <i> Corynebacterium bovis</i> -associated Disease in NSG Mice
A Clinical Scoring Systems for the Evaluation of <i> Corynebacterium bovis</i> -associated Disease in NSG Mice Open
Clinical signs of Corynebacterium bovis infections are well-known in athymic nude mice. However, C. bovis can also infect and cause clinical signs in many hirsute, immunocompromised mouse strains such as NSG (NOD. Cg-Prkdc scid Il2rg tm1Wg…
View article: Corneal fibrosis abrogation by a localized AAV-mediated inhibitor of differentiation 3 (Id3) gene therapy in rabbit eyes in vivo
Corneal fibrosis abrogation by a localized AAV-mediated inhibitor of differentiation 3 (Id3) gene therapy in rabbit eyes in vivo Open
View article: Metaphylactic Antibiotic Treatment to Prevent the Transmission of <i>Corynebacterium bovis</i> to Immunocompromised Mouse Offspring
Metaphylactic Antibiotic Treatment to Prevent the Transmission of <i>Corynebacterium bovis</i> to Immunocompromised Mouse Offspring Open
Current methods for eradicating Corynebacterium bovis , such as depopulation, embryo transfer, and cesarean rederivation followed by cross fostering, are expensive, complex, and time-consuming. We investigated a novel method to produce imm…
View article: Does adjuvant therapy reduce postmetastatic survival?
Does adjuvant therapy reduce postmetastatic survival? Open
View article: Linear Polyethylenimine-DNA Nanoconstruct for Corneal Gene Delivery
Linear Polyethylenimine-DNA Nanoconstruct for Corneal Gene Delivery Open
The 22-kDa linear PEI-DNA nanoconstruct is an efficient and well-tolerated vector for corneal gene therapy in vitro and in vivo and could be used as a platform for developing novel gene-based nanomedicine approaches for corneal diseases.
View article: Diazoxide for Lowering Insulin Levels in Breast Cancer Patients
Diazoxide for Lowering Insulin Levels in Breast Cancer Patients Open
Diazoxide is a nondiuretic benzothiadiazine that produces hyperglycemia by lowering insulin levels through activation of ATP-sensitive K1-channels and stimulating insulin degradation in the lysosomal system. Its effect on cancer growth is …
View article: Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer
Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer Open
View article: Adjuvant Therapy Reduces Rate of Dissemination but Shortens Survival Thereafter
Adjuvant Therapy Reduces Rate of Dissemination but Shortens Survival Thereafter Open
In the subgroup of patients who suffer from metastases despite adjuvant therapy, survival after dissemination is shortened. This is partially due to an adjuvant chemotherapy-induced resistance to previous treatment and may be similar after…