Michael Kabesch
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View article: Timely Association of RSV Hospitalisation Waves in Children with the Detection of SARS-CoV-2 in the General Population in Eastern Bavaria
Timely Association of RSV Hospitalisation Waves in Children with the Detection of SARS-CoV-2 in the General Population in Eastern Bavaria Open
Background: The Respiratory Syncytial Virus (RSV) season of 2023/2024 was conspicuously different from previous seasons, with an abrupt decrease in hospitalisation rates at the peak of the season, leading to two lower peaks instead of the …
View article: Schweres Asthma bei Kindern und Jugendlichen
Schweres Asthma bei Kindern und Jugendlichen Open
Zusammenfassung Hintergrund Asthma bronchiale ist die häufigste chronische Atemwegserkrankung im Kindes- und Jugendalter. Während der Großteil der Patient:innen unter leitliniengerechter Therapie gut behandelt werden kann, leidet eine rele…
View article: Influence of infant fucosyltransferase polymorphisms on the association of maternal secretor status with child outcomes: the Ulm birth cohort studies
Influence of infant fucosyltransferase polymorphisms on the association of maternal secretor status with child outcomes: the Ulm birth cohort studies Open
The influence of maternal secretor status and child fucosyltransferase (FUT2) polymorphisms on respiratory and ear infections, and growth, is an emerging research area. But, the impact of discordant secretor status between mother and infan…
View article: Atopic Dermatitis ( <scp>AD</scp> ) Related Cord Blood <scp>DNA</scp> Methylation Patterns Are Linked to Maternal <scp>AD</scp>
Atopic Dermatitis ( <span>AD</span> ) Related Cord Blood <span>DNA</span> Methylation Patterns Are Linked to Maternal <span>AD</span> Open
View article: Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History
Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History Open
Background Early identification of children at risk of asthma attacks is important for optimizing treatment strategies. We aimed to integrate salivary microbiome and serum inflammatory mediator profiles with asthma attacks history to devel…
View article: Genetic characterization of preschool wheeze phenotypes
Genetic characterization of preschool wheeze phenotypes Open
Preschool wheeze phenotypes displayed distinct patterns of single nucleotide polymorphism associations and genetic enrichment with asthma-related traits. These results indicate distinct etiologies of wheeze phenotypes, which could inform s…
View article: Case Report: Two episodes of hyperinflammation in an infant consistent with multisystem inflammatory syndrome in children: recurrence or rather two different diseases?
Case Report: Two episodes of hyperinflammation in an infant consistent with multisystem inflammatory syndrome in children: recurrence or rather two different diseases? Open
Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory disease that occurs after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report a 9-month-old male infant with two episodes of hy…
View article: Neurocognitive and emotional long-term effects of COVID-19 infections in children and adolescents: results from a clinical survey in Bavaria, Germany
Neurocognitive and emotional long-term effects of COVID-19 infections in children and adolescents: results from a clinical survey in Bavaria, Germany Open
Background While children and adolescents typically experience mild symptoms during the acute phase of the COVID-19 infection, some may develop severe post-infectious symptoms. In our study Post-COVID Kids Bavaria we integrated somatic and…
View article: Healthcare evaluation for children and adolescents in the Bavarian PoCo network: A prospective longitudinal study
Healthcare evaluation for children and adolescents in the Bavarian PoCo network: A prospective longitudinal study Open
View article: RSV is the main cause of severe respiratory infections in infants and young children in Germany - data from the prospective, multicenter PAPI study 2021–2023
RSV is the main cause of severe respiratory infections in infants and young children in Germany - data from the prospective, multicenter PAPI study 2021–2023 Open
Summary Background Respiratory syncytial virus (RSV) is one of the main causes of morbidity in infants and young children worldwide. Current data on RSV-associated disease burden in Germany before the introduction of new immunization strat…
View article: Epigenome‐Wide Association Study of Asthma Exacerbations in Europeans
Epigenome‐Wide Association Study of Asthma Exacerbations in Europeans Open
Background Asthma exacerbations (AEs) represent the major contributor to the global asthma burden. Although genetic and environmental factors have been associated with AEs, the role of epigenetics remains uncovered. Objective This study ai…
View article: Association of Corticosteroid Inhaler Type with Saliva Microbiome in Moderate-to-Severe Pediatric Asthma
Association of Corticosteroid Inhaler Type with Saliva Microbiome in Moderate-to-Severe Pediatric Asthma Open
Background/Objectives: Metered-dose inhalers (MDIs) and dry powder inhalers (DPIs) are common inhaled corticosteroid (ICS) inhaler devices. The difference in formulation and administration technique of these devices may influence oral cavi…
View article: The Exposure and Health Examination Survey mother-child(ren) cohort profile: applying the exposome to the comprehension of child’s health and development joining singletons and twins data
The Exposure and Health Examination Survey mother-child(ren) cohort profile: applying the exposome to the comprehension of child’s health and development joining singletons and twins data Open
The Exposure and Health Examination Survey (EXHES) cohort aims to elucidate the impact of environmental exposures (the external exposome) and their biological markers (the internal exposome) on childhood health conditions, asthma and aller…
View article: Prevalence of and Factors Influencing Oral Health Behaviours in 2-Year-Old Children: A Cross-Sectional Analysis of Data from the KUNO-Kids Health Study
Prevalence of and Factors Influencing Oral Health Behaviours in 2-Year-Old Children: A Cross-Sectional Analysis of Data from the KUNO-Kids Health Study Open
Introduction: This questionnaire-based investigation aimed to assess oral health behaviour (OHB) in 2-year-old children taking part in a birth cohort study and to identify relationships between general health, socioeconomic as well as psyc…
View article: Risk factors for substantial weight retention at 1 year postpartum: evidence from a German birth cohort study (KUNO-Kids)
Risk factors for substantial weight retention at 1 year postpartum: evidence from a German birth cohort study (KUNO-Kids) Open
Purpose Postpartum weight retention (PPWR) increases the risk of overweight and obesity. This study aims to identify risk factors for substantial weight retention (≥ 5 kg) at 1 year postpartum. Methods Data were obtained from N = 747 mothe…
View article: Longitudinal predictors for internalizing and externalizing symptomatology at age 4: KUNO-Kids cohort study
Longitudinal predictors for internalizing and externalizing symptomatology at age 4: KUNO-Kids cohort study Open
Introduction Numerous early-life risk factors are thought to significantly contribute to the development of psychological problems in toddlerhood. However, these factors have seldom been investigated concomitantly and longitudinally, and f…
View article: Kinder und Jugendliche mit Post-COVID-Syndrom: eine qualitative Studie zu Erfahrungen und Zufriedenheit mit der Versorgung in einem Modellprojekt in Bayern (Post-COVID Kids Bavaria)
Kinder und Jugendliche mit Post-COVID-Syndrom: eine qualitative Studie zu Erfahrungen und Zufriedenheit mit der Versorgung in einem Modellprojekt in Bayern (Post-COVID Kids Bavaria) Open
The supply of healthcare services, as established and offered in the PoCoKiBa model project, is crucial for families with a child affected by PCS, since it can offer expertise in diagnosis and treatment that is currently not available in r…
View article: Effect of mothers‘ health literacy on early childhood allergy prevention behaviours: results from the KUNO-Kids health study
Effect of mothers‘ health literacy on early childhood allergy prevention behaviours: results from the KUNO-Kids health study Open
View article: Association of blood inflammatory phenotypes and asthma burden in children with moderate-to-severe asthma
Association of blood inflammatory phenotypes and asthma burden in children with moderate-to-severe asthma Open
Background Underlying immunological mechanisms in children with moderate-to-severe asthma are complex and unclear. We aimed to investigate the association between blood inflammatory parameters and asthma burden in children with moderate-to…
View article: Assessing external exposome by implementing an Environmental Data Management System using Open Data
Assessing external exposome by implementing an Environmental Data Management System using Open Data Open
Due to the increasing importance of exposome in environmental epidemiology, feasibility and usefulness of an Environmental Data Management System (EDMS) using Open Data was evaluated. The EDMS includes data from 10 European cities (Celje (…
View article: Europe-wide comparison regarding the first medical examination of the newborn after birth: Absence of uniform standards
Europe-wide comparison regarding the first medical examination of the newborn after birth: Absence of uniform standards Open
Currently a European patchwork of different medical guidelines and legal requirements in regard to the first medical examination of the newborn after birth exists. In addition, a variety of professional groups perform the first neonatal ex…
View article: Allergy skin prick tests with COVID-19 vaccines and their contribution to improve vaccination readiness and reduce anxiety
Allergy skin prick tests with COVID-19 vaccines and their contribution to improve vaccination readiness and reduce anxiety Open
View article: Impaired skin barrier and allergic sensitization in 16-year-old adolescents
Impaired skin barrier and allergic sensitization in 16-year-old adolescents Open
Background Transepidermal water loss (TEWL) has been used to measure skin barrier function and has been associated with atopic dermatitis and allergic diseases in infancy. However, few studies have assessed the association between TEWL and…
View article: Exhaled Volatile Organic Compounds for Asthma Control Classification in Children with Moderate to Severe Asthma: Results from the SysPharmPediA Study
Exhaled Volatile Organic Compounds for Asthma Control Classification in Children with Moderate to Severe Asthma: Results from the SysPharmPediA Study Open
Rationale: The early identification of children with poorly controlled asthma is imperative for optimizing treatment strategies. The analysis of exhaled volatile organic compounds (VOCs) is an emerging approach to identify prognosti…
View article: An integrated molecular risk score early in life for subsequent childhood asthma risk
An integrated molecular risk score early in life for subsequent childhood asthma risk Open
Background Numerous children present with early wheeze symptoms, yet solely a subgroup develops childhood asthma. Early identification of children at risk is key for clinical monitoring, timely patient‐tailored treatment, and preventing ch…
View article: Stratum corneum and microbial biomarkers precede and characterize childhood atopic dermatitis
Stratum corneum and microbial biomarkers precede and characterize childhood atopic dermatitis Open
Background Atopic dermatitis (AD) is the most common paediatric inflammatory skin disease. There are currently no robust biomarkers that could reliably predict its manifestation, and on the molecular level, it is less well characterized th…
View article: RSV Infektionen bei Säuglingen und Kleinkindern - Daten zur Krankheitslast aus der PAPI Studie
RSV Infektionen bei Säuglingen und Kleinkindern - Daten zur Krankheitslast aus der PAPI Studie Open
Hintergrund Infektionen der unteren Atemwege (LRTI) mit dem Respiratorische Synzytial-Virus (RSV) sind häufiger Hospitalisierungsgrund bei Säuglingen und Kleinkindern. Für Deutschland liegen keine aktuellen Daten zu Krankheitslast und Verl…
View article: Directed acyclic graph for epidemiological studies in childhood food allergy: Construction, user's guide, and application
Directed acyclic graph for epidemiological studies in childhood food allergy: Construction, user's guide, and application Open
Understanding modifiable prenatal and early life causal determinants of food allergy is important for the prevention of the disease. Randomized clinical trials studying environmental and dietary determinants of food allergy may not always …
View article: Effects of infection control measures towards preventing SARS-CoV-2 outbreaks in a German choir boarding school from March 2020 to April 2022
Effects of infection control measures towards preventing SARS-CoV-2 outbreaks in a German choir boarding school from March 2020 to April 2022 Open
Background Singing in a choir was associated with larger outbreaks in the beginning of the SARS-CoV-2 pandemic. Materials and methods We report on the effect and acceptance of various infection control measures on the occurrence of SARS-Co…
View article: Effect of QT interval-prolonging drugs taken in pregnancy on the neonatal QT interval
Effect of QT interval-prolonging drugs taken in pregnancy on the neonatal QT interval Open
Introduction: Acquired QT interval prolongations due to drug side effects can result in detrimental arrhythmia. Maternal use of placenta-permeable drugs may lead to fetal exposure, thus leading to an increased risk of neonatal QT prolongat…