Michael Kenn
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View article: Flexible Risk Evidence Combination Rules in Breast Cancer Precision Therapy
Flexible Risk Evidence Combination Rules in Breast Cancer Precision Therapy Open
Evidence theory by Dempster-Shafer for determination of hormone receptor status in breast cancer samples was introduced in our previous paper. One major topic pointed out here is the link between pieces of evidence found from different ori…
View article: Clustering molecular dynamics conformations of the CC’-loop of the PD-1 immuno-checkpoint receptor
Clustering molecular dynamics conformations of the CC’-loop of the PD-1 immuno-checkpoint receptor Open
Molecular mechanisms within the checkpoint receptor PD-1 are essential for its activation by PD-L1 as well as for blocking such an activation via checkpoint inhibitors. We use molecular dynamics to scrutinize patterns of atomic motion in P…
View article: Molecular dynamics identifies semi-rigid domains in the PD-1 checkpoint receptor bound to its natural ligand PD-L1
Molecular dynamics identifies semi-rigid domains in the PD-1 checkpoint receptor bound to its natural ligand PD-L1 Open
Cells in danger of being erroneously attacked by leucocytes express PD-L1 on their surface. These cells activate PD-1 on attacking leucocytes and send them to death, thus curbing erroneous, autoimmune attack. Unfortunately, cancer cells ex…
View article: Decision Theory versus Conventional Statistics for Personalized Therapy of Breast Cancer
Decision Theory versus Conventional Statistics for Personalized Therapy of Breast Cancer Open
Estrogen and progesterone receptors being present or not represents one of the most important biomarkers for therapy selection in breast cancer patients. Conventional measurement by immunohistochemistry (IHC) involves errors, and numerous …
View article: Galectin network in osteoarthritis: galectin-4 programs a pathogenic signature of gene and effector expression in human chondrocytes in vitro
Galectin network in osteoarthritis: galectin-4 programs a pathogenic signature of gene and effector expression in human chondrocytes in vitro Open
View article: Decision theory for precision therapy of breast cancer
Decision theory for precision therapy of breast cancer Open
View article: Erratum: Gruber, E.S.; et al. The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer. Cells 2019, 8, 1357
Erratum: Gruber, E.S.; et al. The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer. Cells 2019, 8, 1357 Open
The authors wish to make the following change to their paper [...]
View article: Microarray Normalization Revisited for Reproducible Breast Cancer Biomarkers
Microarray Normalization Revisited for Reproducible Breast Cancer Biomarkers Open
Precision medicine for breast cancer relies on biomarkers to select therapies. However, the reliability of biomarkers drawn from gene expression arrays has been questioned and calls for reassessment, in particular for large datasets. We re…
View article: The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer
The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer Open
AF1q impairs survival in hematologic and solid malignancies. AF1q expression is associated with tumor progression, migration and chemoresistance and acts as a transcriptional co-activator in WNT and STAT signaling. This study evaluates the…
View article: Co-expressed genes enhance precision of receptor status identification in breast cancer patients
Co-expressed genes enhance precision of receptor status identification in breast cancer patients Open
We demonstrate a sound mathematical basis for the fusion of information, even if partly contradictive. The concept is extendable to more than three sources of information, as particularly important for OMICS data. The overall number of und…
View article: Galectin-8 induces functional disease markers in human osteoarthritis and cooperates with galectins-1 and -3
Galectin-8 induces functional disease markers in human osteoarthritis and cooperates with galectins-1 and -3 Open
The reading of glycan-encoded signals by tissue lectins is considered a major route of the flow of biological information in many (patho)physiological processes. The arising challenge for current research is to proceed from work on a disti…
View article: Functional cooperation of Galectin-8 with Galectin-1 and -3 in triggering disease markers of human osteoarthritis
Functional cooperation of Galectin-8 with Galectin-1 and -3 in triggering disease markers of human osteoarthritis Open
View article: Gene expression information improves reliability of receptor status in breast cancer patients
Gene expression information improves reliability of receptor status in breast cancer patients Open
Immunohistochemical (IHC) determination of receptor status in breast cancer patients is frequently inaccurate. Since it directs the choice of systemic therapy, it is essential to increase its reliability. We increase the validity of IHC re…
View article: Geometry Dynamics of<b><i>α</i></b>-Helices in Different Class I Major Histocompatibility Complexes
Geometry Dynamics of<b><i>α</i></b>-Helices in Different Class I Major Histocompatibility Complexes Open
MHC α -helices form the antigen-binding cleft and are of particular interest for immunological reactions. To monitor these helices in molecular dynamics simulations, we applied a parsimonious fragment-fitting method to trace the axes of th…