Michael Koeppen
YOU?
Author Swipe
View article: Plexin C1 modulates metabolic programming for resolution of severe inflammation
Plexin C1 modulates metabolic programming for resolution of severe inflammation Open
Persistent, unresolved inflammatory processes disrupt the complex homeostatic state and lead to severe disease, ultimately resulting in organ failure, shock, and death. The mediators that monitor and control the programmed mechanisms in ti…
View article: Early versus Late Initiation of ECMO (ELIEO): study protocol of a prospective, randomized, multicenter study (Preprint)
Early versus Late Initiation of ECMO (ELIEO): study protocol of a prospective, randomized, multicenter study (Preprint) Open
BACKGROUND Acute respiratory distress syndrome (ARDS) is caused by an acute pulmonary inflammation, resulting in significant hypoxia. Current treatment is symptomatic, using mechanical ventilation, and in extreme cases the initiation of e…
View article: Neutrophil ADAM10 promotes migration and inflammation in ARDS by modulating adhesion and chemokine signaling
Neutrophil ADAM10 promotes migration and inflammation in ARDS by modulating adhesion and chemokine signaling Open
Acute respiratory distress syndrome (ARDS) is characterized by excessive neutrophil recruitment, endothelial barrier dysfunction, and persistent inflammation. A Disintegrin and Metalloproteinase 10 (ADAM10) regulates leukocyte trafficking …
View article: Modulation of Neutrophil Recruitment and Inflammatory Signaling in Acute Respiratory Distress Syndrome by Leukotriene Inhibitors Montelukast and Zileuton
Modulation of Neutrophil Recruitment and Inflammatory Signaling in Acute Respiratory Distress Syndrome by Leukotriene Inhibitors Montelukast and Zileuton Open
Acute respiratory distress syndrome (ARDS) is characterized by excessive neutrophil‐driven inflammation and remains a leading cause of mortality in critical care. Leukotriene‐modifying agents, such as montelukast (a CysLTR1 antagonist) and…
View article: Erratum zu: Extrakorporale Verfahren bei der Sepsis
Erratum zu: Extrakorporale Verfahren bei der Sepsis Open
View article: Interpretable Machine Learning Models for Predicting Perioperative Myocardial Injury in Non-Cardiac Surgery
Interpretable Machine Learning Models for Predicting Perioperative Myocardial Injury in Non-Cardiac Surgery Open
View article: Explainable Boosting Machine approach identifies risk factors for acute renal failure
Explainable Boosting Machine approach identifies risk factors for acute renal failure Open
View article: Semaphorin 7A coordinates neutrophil response during pulmonary inflammation and sepsis
Semaphorin 7A coordinates neutrophil response during pulmonary inflammation and sepsis Open
Pulmonary defense mechanisms are critical for host integrity during pneumonia and sepsis. This defense is fundamentally dependent on the activation of neutrophils during the innate immune response. Recent work has shown that semaphorin 7A …
View article: Patient-Related Factors Associated with Adverse Outcomes Following Weaning from Veno-Arterial Extracorporeal Membrane Oxygenation
Patient-Related Factors Associated with Adverse Outcomes Following Weaning from Veno-Arterial Extracorporeal Membrane Oxygenation Open
Background: Veno-arterial extracorporeal membrane oxygenation (vaECMO) removal reflects a critical moment and factors of adverse outcomes are incompletely understood. Thus, we studied various patient-related factors during vaECMO removal t…
View article: Early vvECMO implantation may be associated with lower mortality in ARDS
Early vvECMO implantation may be associated with lower mortality in ARDS Open
Background Venovenous extracorporeal membrane oxygenation (vvECMO) is used to treat hypoxia in patients with severe acute respiratory distress syndrome (ARDS). Nevertheless, uncertainty exists regarding the optimal timing of initiation of …
View article: The Intriguing Role of Hypoxia-Inducible Factor in Myocardial Ischemia and Reperfusion: A Comprehensive Review
The Intriguing Role of Hypoxia-Inducible Factor in Myocardial Ischemia and Reperfusion: A Comprehensive Review Open
Hypoxia-inducible factors (HIFs) play a crucial role in cellular responses to low oxygen levels during myocardial ischemia and reperfusion injury. HIF stabilizers, originally developed for treating renal anemia, may offer cardiac protectio…
View article: Echocardiography as a Tool to Assess Cardiac Function in Critical Care—A Review
Echocardiography as a Tool to Assess Cardiac Function in Critical Care—A Review Open
In critically ill patients, hemodynamic disturbances are common and often lead to a detrimental outcome. Frequently, invasive hemodynamic monitoring is required for patients who are hemodynamically unstable. Although the pulmonary artery c…
View article: Inhaled prostacyclin therapy in the acute respiratory distress syndrome: a randomized controlled multicenter trial
Inhaled prostacyclin therapy in the acute respiratory distress syndrome: a randomized controlled multicenter trial Open
View article: COVID-19 does not influence functional status after ARDS therapy
COVID-19 does not influence functional status after ARDS therapy Open
Rationale Health-related quality of life after surviving acute respiratory distress syndrome has come into focus in recent years, especially during the coronavirus disease 2019 pandemic. Objectives A total of 144 patients with acute respir…
View article: Membrane oxygenator longevity was higher in argatroban‐treated patients undergoing <scp>vvECMO</scp>
Membrane oxygenator longevity was higher in argatroban‐treated patients undergoing <span>vvECMO</span> Open
Background In severe acute respiratory distress syndrome (ARDS), venovenous extracorporeal membrane oxygenation (vvECMO) can be a lifesaver. However, anticoagulation therapy is mandatory because the nonendothelial extracorporeal surface in…
View article: Corrigendum: Methylene blue dosing strategies in critically ill adults with shock—A retrospective cohort study
Corrigendum: Methylene blue dosing strategies in critically ill adults with shock—A retrospective cohort study Open
[This corrects the article DOI: 10.3389/fmed.2022.1014276.].
View article: Dynamic of SOFA Score Predicts Functionality after ARDS Therapy
Dynamic of SOFA Score Predicts Functionality after ARDS Therapy Open
Rationale : Health-related quality of life after surviving acute respiratory distress syndrome has come into focus in recent years, especially during the coronavirus disease 2019 pandemic. Objectives : A total of 143 patients with acute re…
View article: Methylene blue dosing strategies in critically ill adults with shock—A retrospective cohort study
Methylene blue dosing strategies in critically ill adults with shock—A retrospective cohort study Open
Background Shock increases mortality in the critically ill and the mainstay of therapy is the administration of vasopressor agents to achieve hemodynamic targets. In the past, studies have found that the NO-pathway antagonist methylene blu…
View article: Myeloid hypoxia-inducible factor HIF1A provides cardio-protection during ischemia and reperfusion via induction of netrin-1
Myeloid hypoxia-inducible factor HIF1A provides cardio-protection during ischemia and reperfusion via induction of netrin-1 Open
The transcription factor hypoxia-inducible factor HIF1A induces cardioprotection from ischemia and reperfusion injury. Here, we investigate tissue-specific pathways that are critical for HIF1A-elicited tissue protection. Initial studies sh…
View article: Methylene blue dosing strategies in critically ill adults with shock – a retrospective cohort study
Methylene blue dosing strategies in critically ill adults with shock – a retrospective cohort study Open
Background : Shock increases mortality in the critically ill and the mainstay of therapy is the administration of vasopressor agents to achieve hemodynamic targets. In the past, studies have found that the NO-pathway antagonist methylene b…
View article: Inhaled Prostacyclin Improves Oxygenation in Patients with COVID-19-induced Acute Respiratory Distress Syndrome – a randomized controlled multicenter trial
Inhaled Prostacyclin Improves Oxygenation in Patients with COVID-19-induced Acute Respiratory Distress Syndrome – a randomized controlled multicenter trial Open
Background. Acute Respiratory Distress Syndrome (ARDS) results in significant hypoxia, and ARDS is the central pathology of COVID-19. Inhaled prostacyclin has been proposed as a therapy for ARDS, but data regarding its role in this syndrom…
View article: Methylene blue dosing strategies in critically ill adults with shock – a retrospective cohort study
Methylene blue dosing strategies in critically ill adults with shock – a retrospective cohort study Open
Background : Shock increases mortality in the critically ill and the mainstay of therapy is the administration of vasopressor agents to achieve hemodynamic targets. In the past, studies have found that the NO-pathway antagonist methylene b…
View article: Inhaled Prostacyclin Improves Oxygenation in Patients with COVID-19-induced Acute Respiratory Distress Syndrome – a randomized controlled multicenter trial
Inhaled Prostacyclin Improves Oxygenation in Patients with COVID-19-induced Acute Respiratory Distress Syndrome – a randomized controlled multicenter trial Open
Background. Acute Respiratory Distress Syndrome (ARDS) results in significant hypoxia, and ARDS is the central pathology of COVID-19. Inhaled prostacyclin has been proposed as a therapy for ARDS, but data regarding its role in this syndrom…
View article: COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutants
COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutants Open
As global vaccination campaigns against SARS-CoV-2 proceed, there is particular interest in the longevity of immune protection, especially with regard to increasingly infectious virus variants. Neutralizing antibodies (Nabs) targeting the …
View article: Myeloid hypoxia-inducible factor HIF1A provides cardio-protection during ischemia and reperfusion via induction of netrin-1
Myeloid hypoxia-inducible factor HIF1A provides cardio-protection during ischemia and reperfusion via induction of netrin-1 Open
The transcription factor hypoxia-inducible factor HIF1A elicitics cardioprotection from ischemia and reperfusion injury. Here, we investigated tissue-specific pathways that are critical for HIF1A-elicited tissue protection. Initial studies…
View article: Inhaled Prostacyclin Improves Oxygenation in Patients with COVID-19-induced Acute Respiratory Distress Syndrome
Inhaled Prostacyclin Improves Oxygenation in Patients with COVID-19-induced Acute Respiratory Distress Syndrome Open
Summary Background Acute Respiratory Distress Syndrome (ARDS) results in significant hypoxia, and ARDS is the central pathology of COVID-19. Inhaled prostacyclin has been proposed as a therapy for ARDS, but data regarding its role in this …
View article: Control of Neutrophil activation through Semaphorin 7A-Plexin C1 is essential for immune defense during pulmonary sepsis
Control of Neutrophil activation through Semaphorin 7A-Plexin C1 is essential for immune defense during pulmonary sepsis Open
Pulmonary defense mechanisms are critical for host integrity during the early phase of pneumonia and sepsis. These processes are fundamentally dependent on the activation of neutrophils during the early phase of the innate immune response.…
View article: COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutants
COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutants Open
As global vaccination campaigns against SARS-CoV-2 proceed, there is particular interest in the longevity of immune protection, especially with regard to increasingly infectious virus variants. Neutralizing antibodies (Nabs) targeting the …
View article: Machine learning identifies ICU outcome predictors in a multicenter COVID-19 cohort
Machine learning identifies ICU outcome predictors in a multicenter COVID-19 cohort Open
View article: Machine Learning Identifies ICU Outcome Predictors in a Multicenter COVID-19 Cohort.
Machine Learning Identifies ICU Outcome Predictors in a Multicenter COVID-19 Cohort. Open
Background. Intensive Care Resources are heavily utilized during the COVID-19 pandemic. However, risk stratification and prediction of SARS-CoV-2 patient clinical outcomes upon ICU admission remain inadequate. This study aimed to develop a…