Michael Kölch
YOU?
Author Swipe
View article: Off-label drug use in children and adolescents treated with antidepressants and antipsychotics: results from a prospective multicenter trial
Off-label drug use in children and adolescents treated with antidepressants and antipsychotics: results from a prospective multicenter trial Open
Background/Objectives Off-label psychopharmacologic medication use is widespread in child and adolescent psychiatry, but little is known about its associated factors. This study aimed to assess frequency and determinants of off-label use o…
View article: “Ready for Landing”—study protocol for the evaluation of a brief sleep hygiene group intervention for youth with psychiatric disorders
“Ready for Landing”—study protocol for the evaluation of a brief sleep hygiene group intervention for youth with psychiatric disorders Open
Background Many children and adolescents with psychiatric disorders struggle with sleep problems that oftentimes stay unaddressed in therapeutic settings due to limited resources. Still, there is evidence that improving insufficient sleep …
View article: Sex-Specific Differences in Antidepressant and Antipsychotic Treatment Outcomes and Serum Levels in Children and Adolescents
Sex-Specific Differences in Antidepressant and Antipsychotic Treatment Outcomes and Serum Levels in Children and Adolescents Open
Introduction: Sex-specific differences in psychopharmacological treatment have gained increasing attention in adults, with studies showing that women often have higher serum concentrations of psychotropic drugs due to biological difference…
View article: Electroencephalogram features support the retrogenesis hypothesis of Alzheimer's disease: Exploratory comparison of brain changes in aging and childhood
Electroencephalogram features support the retrogenesis hypothesis of Alzheimer's disease: Exploratory comparison of brain changes in aging and childhood Open
Background The retrogenesis hypothesis (RH) suggests that the functional and cognitive decline observed in Alzheimer's disease dementia mirrors in reverse order the brain development during childhood and adolescence. Objective Equivalent e…
View article: Medication Nonadherence in Children and Adolescents with ADHD
Medication Nonadherence in Children and Adolescents with ADHD Open
Objective: Attention-deficit/hyperactivity disorder (ADHD) affects 6–10 % of children and adolescents worldwide. While psychopharmacological treatments effectively reduce symptoms, incomplete adherence is common, diminishing their effectiv…
View article: Neuronal network analysis during short time transcranial direct current stimulation with permanent EEG measurement in early childhood: a feasibility study
Neuronal network analysis during short time transcranial direct current stimulation with permanent EEG measurement in early childhood: a feasibility study Open
Transcranial direct current stimulation (tDCS) as a non-invasive stimulation is still in the experimental stage for many psychiatric disorders even in adults. The use of tDCS provides an opportunity to influence neural networks and their f…
View article: Increased Serum Neurofilament Light Chain Concentration Associated With Microglial Morphology Changes in Chronically‐Starved Mice
Increased Serum Neurofilament Light Chain Concentration Associated With Microglial Morphology Changes in Chronically‐Starved Mice Open
Objective Anorexia nervosa (AN) is associated with hyperactivity, amenorrhea, and brain atrophy. Weight rehabilitation reversed these symptoms, although the underlying pathophysiological mechanisms are mostly unknown. Serum neurofilament l…
View article: Influences on stigmatization of adults and adolescents with a cannabis use disorder – A representative survey study
Influences on stigmatization of adults and adolescents with a cannabis use disorder – A representative survey study Open
Aims: Stigma experienced by individuals with a cannabis use disorder (CUD) has been identified as a significant impediment to their engagement with treatment programs. Therefore, this study aims to investigate the effect of sociodemographi…
View article: Changes in Circadian Rhythm in Chronically‐Starved Mice Are Associated With Glial Cell Density Reduction in the Suprachiasmatic Nucleus
Changes in Circadian Rhythm in Chronically‐Starved Mice Are Associated With Glial Cell Density Reduction in the Suprachiasmatic Nucleus Open
Objective Anorexia nervosa (AN) is an eating disorder characterized by severe weight loss and associated with hyperactivity and circadian rhythm disruption. However, the cellular basis of circadian rhythm disruption is poorly understood. G…
View article: Blended digital health intervention for adolescents at high risk with digital media use disorders: protocol for a randomised controlled trial within the Res@t-Consortium
Blended digital health intervention for adolescents at high risk with digital media use disorders: protocol for a randomised controlled trial within the Res@t-Consortium Open
Background Digital media use disorder (DMUD) is a prevalent problem among young people, which can result in adverse consequences and functional impairments across multiple domains of life due to a persistent inability to regulate one’s use…
View article: Integration of a Mental Health App (e-MICHI) Into a Blended Treatment of Depression in Adolescents: Single-Group, Naturalistic Feasibility Trial
Integration of a Mental Health App (e-MICHI) Into a Blended Treatment of Depression in Adolescents: Single-Group, Naturalistic Feasibility Trial Open
Background Major depressive disorder is a common diagnosis among adolescents. Cognitive behavioral therapy is recommended as the first line of treatment. Digital health interventions, such as apps, could contribute to treatment. Advantages…
View article: Psychometric properties of the parent-rated assessment scale of positive and negative parenting behavior (FPNE) in a German sample of school-aged children
Psychometric properties of the parent-rated assessment scale of positive and negative parenting behavior (FPNE) in a German sample of school-aged children Open
Background The aim of this study was to develop and psychometrically evaluate a parent-rated parenting assessment scale including positive and negative dimensions of parenting. Factorial validity, reliability, measurement invariance, laten…
View article: Adolescent Depression: Feasibility Trial of a Blended e-Therapy App in a Naturalistic Outpatient Setting (e-MICHI) (Preprint)
Adolescent Depression: Feasibility Trial of a Blended e-Therapy App in a Naturalistic Outpatient Setting (e-MICHI) (Preprint) Open
BACKGROUND Major Depressive Disorder (MDD) is a common diagnosis among adolescents. Cognitive-behavioral therapy (CBT) is recommended as the first line of treatment. Digital Health Interventions (DHIs), such as apps, could contribute to t…
View article: Bright Light Therapy as Add-On to Inpatient Treatment in Youth With Moderate to Severe Depression
Bright Light Therapy as Add-On to Inpatient Treatment in Youth With Moderate to Severe Depression Open
Importance Major depressive disorder is one of the most common mental disorders among adolescents, entailing severe, long-term psychosocial impairment and a high risk of chronicity. In view of the large number of patients requiring treatme…
View article: Assessment of Affective Dysregulation in Children: Development and Evaluation of a Semi- Structured Interview for Parents and for Children
Assessment of Affective Dysregulation in Children: Development and Evaluation of a Semi- Structured Interview for Parents and for Children Open
Background Children with affective dysregulation (AD) show an excessive reactivity to emotionally positive or negative stimuli, typically manifesting in chronic irritability, severe temper tantrums, and sudden mood swings. AD shows a large…
View article: Therapeutic Drug Monitoring in Children and Adolescents: Findings on Fluoxetine from the TDM-VIGIL Trial
Therapeutic Drug Monitoring in Children and Adolescents: Findings on Fluoxetine from the TDM-VIGIL Trial Open
Fluoxetine is the recommended first-line antidepressant in many therapeutic guidelines for children and adolescents. However, little is known about the relationships between drug dose and serum level as well as the therapeutic serum refere…
View article: Clock Genes Profiles as Diagnostic Tool in (Childhood) ADHD—A Pilot Study
Clock Genes Profiles as Diagnostic Tool in (Childhood) ADHD—A Pilot Study Open
Attention deficit hyperactivity disorder (ADHD) is a very common disorder in children and adults. A connection with sleep disorders, and above all, disorders of the circadian rhythm are the subject of research and debate. The circadian sys…
View article: Attitudes toward innovative mental health treatment approaches in Germany: E-mental health and home treatment
Attitudes toward innovative mental health treatment approaches in Germany: E-mental health and home treatment Open
E-mental health and home treatment are treatment approaches that have proven to be effective, but are only slowly implemented in the German health care system. This paper explores the attitudes toward these innovative treatment approaches.…
View article: Electroconvulsive Therapy in Children and Adolescents in Germany—A Case Series From 3 University Hospitals
Electroconvulsive Therapy in Children and Adolescents in Germany—A Case Series From 3 University Hospitals Open
Objective Electroconvulsive therapy (ECT) is a well-established, safe, and efficacious treatment for severe psychiatric disorders. In children and adolescents, it is used much less frequently than in adults, likely because of a lack of kno…
View article: Possible Effects of Bright Light Therapy on Electroencephalogram-Vigilance in the Treatment of Depression in Adolescents: A Pilot Study
Possible Effects of Bright Light Therapy on Electroencephalogram-Vigilance in the Treatment of Depression in Adolescents: A Pilot Study Open
Background Chronotherapeutic treatments for depression, such as bright light therapy (BLT), are non-invasive and produce almost no side effects. However, study evidence for reliable neurobiological changes associated with treatment respons…
View article: Irritability and Emotional Impulsivity as Core Feature of ADHD and ODD in Children
Irritability and Emotional Impulsivity as Core Feature of ADHD and ODD in Children Open
The categorical approach of diagnosing mental disorders entails the problem of frequently occurring comorbidities, suggesting a more parsimonious structure of psychopathology. In this study, we therefore aim to assess how affective dysregu…