Michael Konney Laryea
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View article: Nanoemulsion encapsulation improves the stability and antibacterial efficacy of orange (Citrus x sinensis) peel essential oil
Nanoemulsion encapsulation improves the stability and antibacterial efficacy of orange (Citrus x sinensis) peel essential oil Open
Antimicrobial resistance, especially in Pseudomonas aeruginosa, presents a serious global health threat. Natural products like essential oils have shown promising antibacterial properties due to their multi-component systems, which are les…
View article: Pharmaceutical Waste Disposal: A Cross‐Sectional Survey of Disposal Practices and Awareness in Sefwi Wiawso Municipality, Ghana
Pharmaceutical Waste Disposal: A Cross‐Sectional Survey of Disposal Practices and Awareness in Sefwi Wiawso Municipality, Ghana Open
Background and Aims The rising global demand for medication has intensified concerns about improper pharmaceutical waste disposal in Ghana. Although disposal laws exist, enforcement is weak. While some Ghanaian regions report poor disposal…
View article: Descriptive analysis of pharmaceutical disposal practices in Sekondi-Takoradi: implications for environmental and public health safety in Ghana
Descriptive analysis of pharmaceutical disposal practices in Sekondi-Takoradi: implications for environmental and public health safety in Ghana Open
Improper disposal of unused and expired medicines from homes, pharmacies, and health facilities continues to introduce pharmaceutical contaminants into the environment, posing risks to terrestrial and aquatic ecosystems. In Sekondi-Takorad…
View article: Synergistic action of phytoconstituents drives the anthelmintic potential of Croton penduliflorus stem bark extracts
Synergistic action of phytoconstituents drives the anthelmintic potential of Croton penduliflorus stem bark extracts Open
The growing resistance to anthelmintic drugs highlights the urgent need for new, plant-derived therapeutics. This study investigates the synergistic anthelmintic activity of Croton penduliflorus stem bark extracts. Soxhlet extraction yield…
View article: Occurrence and ecological risk assessment of commonly used pharmaceuticals in water and soil of Sefwi Wiawso, Ghana
Occurrence and ecological risk assessment of commonly used pharmaceuticals in water and soil of Sefwi Wiawso, Ghana Open
Over the past two decades, pharmaceutical pollutants have emerged as a significant global concern due to their harmful effects on water quality, human health, and aquatic ecosystems. Pharmaceuticals play an essential role in medicine and v…
View article: Peptide Extract from Red Kidney Beans, Phaseolus vulgaris (Fabaceae), Shows Promising Antimicrobial, Antibiofilm, and Quorum Sensing Inhibitory Effects
Peptide Extract from Red Kidney Beans, Phaseolus vulgaris (Fabaceae), Shows Promising Antimicrobial, Antibiofilm, and Quorum Sensing Inhibitory Effects Open
The rapid spread of multidrug-resistant bacteria has led to an increased risk of infectious diseases. Pseudomonas aeruginosa, in particular, poses a significant obstacle due to its propensity to rapidly acquire resistance to conventional a…
View article: Abstract 2266 Amaryllidaceae Alkaloids as Potential Inhibitors of the Trypanosoma cruzi Trans-sialidase Enzyme: Unique Insights from Computational Studies
Abstract 2266 Amaryllidaceae Alkaloids as Potential Inhibitors of the Trypanosoma cruzi Trans-sialidase Enzyme: Unique Insights from Computational Studies Open
Trypanosoma cruzi is the causative agent of Chagas disease (CD). So far, nifurtimox and benznidazole are currently approved to treat CD in acute and chronic phases. To minimize the danger of disease transmission and as a therapy, new compo…
View article: Marine-Derived Furanones Targeting Quorum-Sensing Receptors in <i>Pseudomonas aeruginosa</i>: Molecular Insights and Potential Mechanisms of Inhibition
Marine-Derived Furanones Targeting Quorum-Sensing Receptors in <i>Pseudomonas aeruginosa</i>: Molecular Insights and Potential Mechanisms of Inhibition Open
The quorum-sensing (QS) machinery in disease-causing microorganisms is critical in developing antibiotic resistance. In Pseudomonas aeruginosa, QS is involved in biofilm formation, virulence factors production, and general tolerance to ant…
View article: Targeting Quorum Sensing in <i>Pseudomonas aeruginosa</i> Using Marine‐Derived Metabolites—An <i>In Silico</i> Approach
Targeting Quorum Sensing in <i>Pseudomonas aeruginosa</i> Using Marine‐Derived Metabolites—An <i>In Silico</i> Approach Open
Quorum sensing (QS), a cell‐to‐cell communication among bacteria, is one of the leading mechanisms of antibiotic resistance. Opportunistic bacteria such as Pseudomonas aeruginosa employ QS in their pathogenicity. Marine‐derived natural pro…
View article: De novo peptides as potential antimicrobial agents
De novo peptides as potential antimicrobial agents Open
The phenomenon of antimicrobial resistance threatens our ability to treat common infections. The clinical pipeline for new antimicrobials is pretty much dry and hence, there is a need for the development of new antimicrobial agents with lo…
View article: Antioxidant, antimicrobial, and antibiofilm properties of essential oils extracted from <i>Dialium guineense</i>
Antioxidant, antimicrobial, and antibiofilm properties of essential oils extracted from <i>Dialium guineense</i> Open
This study aimed to explore the chemical composition and biological properties of Dialium guineense essential oils derived from its fruit and leaf. These oils have significant potential as natural alternatives in industries such as food, p…
View article: Antimalarial, Antioxidant, and Toxicological Evaluation of Extracts of Celtis africana, Grosseria vignei, Physalis micrantha, and Stachytarpheta angustifolia
Antimalarial, Antioxidant, and Toxicological Evaluation of Extracts of Celtis africana, Grosseria vignei, Physalis micrantha, and Stachytarpheta angustifolia Open
In many parts of the world, malaria undoubtedly poses a serious threat to health care systems. Malaria treatment has increasingly become complicated, primarily due to the emergence of widespread resistance of the malaria parasites to cheap…
View article: Biological Efficacy and Toxicological Evaluation of Ethanolic Extract of <i>Cassia nodosa</i> Buch.-Ham<i>.</i> (Leguminosae)
Biological Efficacy and Toxicological Evaluation of Ethanolic Extract of <i>Cassia nodosa</i> Buch.-Ham<i>.</i> (Leguminosae) Open
Medicinal plants are used worldwide to treat various diseases. However, scientific validation of the therapeutic potential of most medicinal plants is absent, and little to no information on their potential toxicity exists. It is therefore…
View article: Anti-inflammatory and antioxidant activities of extracts of<i>Reissantia indica, Cissus cornifolia</i>and<i>Grosseria vignei</i>
Anti-inflammatory and antioxidant activities of extracts of<i>Reissantia indica, Cissus cornifolia</i>and<i>Grosseria vignei</i> Open
Unpleasant side effects associated with prolonged use of current anti-inflammatory drugs have necessitated a need for new drugs with limited side effects. Plants rich in antioxidants have been suggested as potential sources of anti-inflamm…
View article: Antimalarial Efficacy and Toxicological Assessment of Extracts of Some Ghanaian Medicinal Plants
Antimalarial Efficacy and Toxicological Assessment of Extracts of Some Ghanaian Medicinal Plants Open
The economic costs associated with morbidity and mortality due to malaria and malaria associated complications in many sub-Saharan countries and other malaria endemic regions of the world are huge. Reports of emergence of parasite resistan…
View article: Anti-inflammatory activities of extracts from<i>Oliva sp., Patella rustica</i>, and<i>Littorina littorea</i>collected from Ghana’s coastal shorelines
Anti-inflammatory activities of extracts from<i>Oliva sp., Patella rustica</i>, and<i>Littorina littorea</i>collected from Ghana’s coastal shorelines Open
Inflammation is one of the means the human body uses to defend itself in the event of infection, trauma, or exposure to toxic substances and it is closely associated with a number of disease symptoms. Steroidal and non-steroidal anti-infla…
View article: Nutritional and anti-nutrient profiles of some Ghanaian spices
Nutritional and anti-nutrient profiles of some Ghanaian spices Open
Spices are generally consumed because of the taste and flavor they add to food. Some are also consumed because of their medicinal properties. We herein report on the nutrient and antinutrient compositions of five Ghanaian spices namely Xyl…