Michael L. Atchison
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View article: Chromatin factor YY1 controls fetal hematopoietic stem cell migration and engraftment in mice
Chromatin factor YY1 controls fetal hematopoietic stem cell migration and engraftment in mice Open
The fetal liver is the primary site of hematopoietic stem cell (HSC) generation during embryonic development. However, the molecular mechanisms governing the transition of hematopoiesis from the fetal liver to the BM remain incompletely un…
View article: YY1-Mediated PcG Regulation Dictates Hematopoietic Stem Cell Fate
YY1-Mediated PcG Regulation Dictates Hematopoietic Stem Cell Fate Open
Hematopoietic stem cells (HSCs) are undifferentiated, pluripotent cells that can either self-renew or differentiate into any of the mature lineage-specific cells in adult blood. Physiological aging and hematological malignancies in humans …
View article: YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity
YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity Open
During B-cell development, cells progress through multiple developmental stages, with the pro-B-cell stage defining commitment to the B-cell lineage. YY1 is a ubiquitous transcription factor that is capable of both activation and repressio…
View article: Unusual lineage plasticity revealed by YY1 knockout in pro-B cells
Unusual lineage plasticity revealed by YY1 knockout in pro-B cells Open
During B cell development, cells progress through multiple developmental stages with the pro-B cell stage defining commitment to the B cell lineage. YY1 is a ubiquitous transcription factor that is capable of both activation and repression…
View article: Multiple lineage-specific epigenetic landscapes at the antigen receptor loci
Multiple lineage-specific epigenetic landscapes at the antigen receptor loci Open
Antigen receptors (AgRs) expressed on B and T cells provide the adaptive immune system with ability to detect numerous foreign antigens. Epigenetic features of B cell receptor (BCR) and T cell receptor (TCR) genes were previously studied i…
View article: Altered 3D chromatin structure permits inversional recombination at the <i>IgH</i> locus
Altered 3D chromatin structure permits inversional recombination at the <i>IgH</i> locus Open
Different mechanisms govern the first and second steps of IgH gene recombination.
View article: YY1 control of mitochondrial‐related genes does not account for regulation of immunoglobulin class switch recombination in mice
YY1 control of mitochondrial‐related genes does not account for regulation of immunoglobulin class switch recombination in mice Open
Immunoglobulin class switch recombination (CSR) occurs in activated B cells with increased mitochondrial mass and membrane potential. Transcription factor Yin Yang 1 (YY1) is critical for CSR and for formation of the DNA loops involved in …
View article: Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases
Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases Open
Systemic lupus erythematosus (SLE) is an autoimmune disorder that predominantly affects women and is driven by autoreactive T cell-mediated inflammation. It is known that individuals with multiple X-chromosomes are at increased risk for de…
View article: Diversity of Epigenetic Features of the Inactive X-Chromosome in NK Cells, Dendritic Cells, and Macrophages
Diversity of Epigenetic Features of the Inactive X-Chromosome in NK Cells, Dendritic Cells, and Macrophages Open
In females, the long non-coding RNA Xist drives X-chromosome Inactivation (XCI) to equalize X-linked gene dosage between sexes. Unlike other somatic cells, dynamic regulation of Xist RNA and heterochromatin marks on the inactive X (Xi) in …
View article: Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cells
Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cells Open
X-chromosome inactivation (XCI) in female lymphocytes is uniquely regulated, as the inactive X (Xi) chromosome lacks localized Xist RNA and heterochromatin modifications. Epigenetic profiling reveals that Xist RNA is lost from the Xi at th…
View article: YY1 controls Eμ-3′RR DNA loop formation and immunoglobulin heavy chain class switch recombination
YY1 controls Eμ-3′RR DNA loop formation and immunoglobulin heavy chain class switch recombination Open
Key Points Transcription factor YY1 regulates the IgH Eμ-3′RR long-distance DNA loop without the YY1 transcriptional activation domain. YY1 constructs that rescue the Eμ-3′RR DNA loop also restore CSR strongly arguing for the necessity of …
View article: YY1 Is Required for Germinal Center B Cell Development
YY1 Is Required for Germinal Center B Cell Development Open
YY1 has been implicated as a master regulator of germinal center B cell development as YY1 binding sites are frequently present in promoters of germinal center-expressed genes. YY1 is known to be important for other stages of B cell develo…
View article: Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X
Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X Open
Significance Females have increased immune responsiveness than males, and they are more likely to develop autoimmune disorders. The mechanism underlying these observations is unclear, and hypotheses suggest an important role for the X chro…