Michael L. Dourson
YOU?
Author Swipe
View article: Estimating safe doses of perfluorooctane sulfonate (PFOS): an international collaboration
Estimating safe doses of perfluorooctane sulfonate (PFOS): an international collaboration Open
Many government agencies and expert groups have estimated a safe dose (aka a "reference dose," [RfD]) for perfluorooctane sulfonate (PFOS). Notably, these agencies have derived safe doses that vary over at least 600-fold range. The range i…
View article: The Future of Uncertainty Factors With <i>In Vitro</i> Studies Using Human Cells
The Future of Uncertainty Factors With <i>In Vitro</i> Studies Using Human Cells Open
New approach methodologies (NAMs), including in vitro toxicology methods such as human cells from simple cell cultures to 3D and organ-on-a-chip models of human lung, intestine, liver, and other organs, are challenging the traditional “nor…
View article: Bioelution, Bioavailability, and Toxicity of Cobalt Compounds Correlate
Bioelution, Bioavailability, and Toxicity of Cobalt Compounds Correlate Open
Based on the wide use of cobalt substances in a range of important technologies, it has become important to predict the toxicological properties of new or lesser-studied substances as accurately as possible. We studied a group of 6 cobalt …
View article: New approaches to risk assessment of chemical mixtures
New approaches to risk assessment of chemical mixtures Open
Assessing the risk of chemical mixtures is an intricate process that should integrate published laboratory data; comparisons with the composition, toxicity, and functionality of similar mixtures; complete analytical characterization of the…
View article: Benchmark dose (BMD) modeling: current practice, issues, and challenges
Benchmark dose (BMD) modeling: current practice, issues, and challenges Open
Benchmark dose (BMD) modeling is now the state of the science for determining the point of departure for risk assessment. Key advantages include the fact that the modeling takes account of all of the data for a particular effect from a par…
View article: Derivation of a no‐significant‐risk‐level for tetrabromobisphenol A based on a threshold non‐mutagenic cancer mode of action
Derivation of a no‐significant‐risk‐level for tetrabromobisphenol A based on a threshold non‐mutagenic cancer mode of action Open
A no‐significant‐risk‐level of 20 mg day –1 was derived for tetrabromobisphenol A (TBBPA). Uterine tumors (adenomas, adenocarcinomas, and malignant mixed Müllerian) observed in female Wistar Han rats from a National Toxicology Program 2‐ye…
View article: Update: Mode of action (MOA) for liver tumors induced by oral exposure to 1,4-dioxane
Update: Mode of action (MOA) for liver tumors induced by oral exposure to 1,4-dioxane Open
Previous work has shown that the weight of evidence supports the hypothesis that 1,4-dioxane causes liver tumors in rodents through cytotoxicity and subsequent regenerative hyperplasia. Questions regarding a lack of concordant findings for…
View article: Quantitative weight of evidence to assess confidence in potential modes of action
Quantitative weight of evidence to assess confidence in potential modes of action Open
The evolved World Health Organization/International Programme on Chemical Safety mode of action (MOA) framework provides a structure for evaluating evidence in pathways of causally linked key events (KE) leading to adverse health effects. …
View article: Managing risks of noncancer health effects at hazardous waste sites: A case study using the Reference Concentration (RfC) of trichloroethylene (TCE)
Managing risks of noncancer health effects at hazardous waste sites: A case study using the Reference Concentration (RfC) of trichloroethylene (TCE) Open
A method for determining a safety range for non-cancer risks is proposed, similar in concept to the range used for cancer in the management of waste sites. This safety range brings transparency to the chemical specific Reference Dose or Co…
View article: Bayesian methods for uncertainty factor application for derivation of reference values
Bayesian methods for uncertainty factor application for derivation of reference values Open
In 2014, the National Research Council (NRC) published Review of EPA's Integrated Risk Information System (IRIS) Process that considers methods EPA uses for developing toxicity criteria for non-carcinogens. These criteria are the Reference…
View article: A case study of potential human health impacts from petroleum coke transfer facilities
A case study of potential human health impacts from petroleum coke transfer facilities Open
Petroleum coke or “petcoke” is a solid material created during petroleum refinement and is distributed via transfer facilities that may be located in densely populated areas. The health impacts from petcoke exposure to residents living in …
View article: Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study
Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study Open
Single point estimates of human health hazard/toxicity values such as a reference dose (RfD) are generally used in chemical hazard and risk assessment programs for assessing potential risks associated with site- or use-specific exposures. …
View article: A Case Study of Potential Human Health Impacts from Petroleum Coke Transfer Facilities
A Case Study of Potential Human Health Impacts from Petroleum Coke Transfer Facilities Open
Petroleum coke or “petcoke” is a solid material created during petroleum refinement is distributed via transfer facilities that may be located in densely populated areas. The health impacts from petcoke exposure to residents living in prox…
View article: A case study of potential human health impacts from petroleum coke transfer facilities
A case study of potential human health impacts from petroleum coke transfer facilities Open
Petroleum coke or “petcoke” is a solid material created during petroleum refinement and is distributed via transfer facilities that may be located in densely populated areas. The health impacts from petcoke exposure to residents living in …