Michael L. Martini
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View article: Removal of painful pelvic screws following spine fusion surgery: outcomes and complications
Removal of painful pelvic screws following spine fusion surgery: outcomes and complications Open
OBJECTIVE The purpose of this study was to evaluate the risks and benefits of removing painful pelvic/iliac screws in spine fusion surgery patients. METHODS A retrospective review identified patients who had traditional iliac and S2-alar-i…
View article: Impact of Frailty and Other Factors as Estimated by HU to Predict Response to Anabolic Bone Medications
Impact of Frailty and Other Factors as Estimated by HU to Predict Response to Anabolic Bone Medications Open
Introduction: Bone health optimization is a key component of the preoperative management of spine surgery patients, as poor bone quality increases the odds of mechanical complications. The present study aimed to achieve the following: (1) …
View article: Significant Reduction in Bone Density as Measured by Hounsfield Units in Patients with Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis
Significant Reduction in Bone Density as Measured by Hounsfield Units in Patients with Ankylosing Spondylitis or Diffuse Idiopathic Skeletal Hyperostosis Open
Background: Multisegmental pathologic autofusion occurs in patients with ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH). It may lead to reduced vertebral bone density due to stress shielding. Methods: This …
View article: The Predictors of Incidental Durotomy in Patients Undergoing Pedicle Subtraction Osteotomy for the Correction of Adult Spinal Deformity
The Predictors of Incidental Durotomy in Patients Undergoing Pedicle Subtraction Osteotomy for the Correction of Adult Spinal Deformity Open
Background: Pedicle subtraction osteotomy (PSO) is a powerful tool for sagittal plane correction in patients with rigid adult spinal deformity (ASD); however, it is associated with high intraoperative blood loss and the increased risk of d…
View article: Dopamine-Depleted Dopamine Transporter Knockout (DDD) Mice: Dyskinesia with L-DOPA and Dopamine D1 Agonists
Dopamine-Depleted Dopamine Transporter Knockout (DDD) Mice: Dyskinesia with L-DOPA and Dopamine D1 Agonists Open
L-DOPA is the mainstay of treatment for Parkinson’s disease (PD). However, over time this drug can produce dyskinesia. A useful acute PD model for screening novel compounds for anti-parkinsonian and L-DOPA-induced dyskinesia (LID) are dopa…
View article: Supplementary Tables 2 - 4 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
Supplementary Tables 2 - 4 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies Open
PDF file - 90KB, Table S2. Tabulated expression values for selected FGFs in lung cancer cell lines from the Cancer Cell Line Encyclopedia. Table S3. Tabulated FGFR1 gene copy number values determined by SISH and associated patient data for…
View article: Data from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
Data from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies Open
Purpose: FGFR1 gene copy number (GCN) is being evaluated as a biomarker for FGFR tyrosine kinase inhibitor (TKI) response in squamous cell lung cancers (SCC). The exclusive use of FGFR1 GCN for predicting FGFR TKI sensitivity assume…
View article: Supplementary Table 1 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
Supplementary Table 1 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies Open
XLSX file - 66KB, Table S1. Compiled and tabulated ponatinib IC50 values, FGF and FGFR expression, FGFR1 gene copy number and characteristics of the 58 lung cancer cell lines.
View article: Supplementary Figure Legends, Figures 1 - 7 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
Supplementary Figure Legends, Figures 1 - 7 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies Open
PDF file - 786KB, Figure S1. FGFR1 immunoblots of extracts from lung cancer cell lines representative of the 58 cell lines employed in the studies. Figure S2. Images and quantification of clonogenic growth assays in selected lung cancer ce…
View article: Supplementary Tables 2 - 4 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
Supplementary Tables 2 - 4 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies Open
PDF file - 90KB, Table S2. Tabulated expression values for selected FGFs in lung cancer cell lines from the Cancer Cell Line Encyclopedia. Table S3. Tabulated FGFR1 gene copy number values determined by SISH and associated patient data for…
View article: Data from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
Data from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies Open
Purpose: FGFR1 gene copy number (GCN) is being evaluated as a biomarker for FGFR tyrosine kinase inhibitor (TKI) response in squamous cell lung cancers (SCC). The exclusive use of FGFR1 GCN for predicting FGFR TKI sensitivity assume…
View article: Supplementary Figure Legends, Figures 1 - 7 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
Supplementary Figure Legends, Figures 1 - 7 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies Open
PDF file - 786KB, Figure S1. FGFR1 immunoblots of extracts from lung cancer cell lines representative of the 58 cell lines employed in the studies. Figure S2. Images and quantification of clonogenic growth assays in selected lung cancer ce…
View article: Supplementary Table 1 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
Supplementary Table 1 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies Open
XLSX file - 66KB, Table S1. Compiled and tabulated ponatinib IC50 values, FGF and FGFR expression, FGFR1 gene copy number and characteristics of the 58 lung cancer cell lines.
View article: Supplementary Table 5 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
Supplementary Table 5 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies Open
XLSX file - 106KB, Table S5. Tabulated FGFR1, FGF2 and FGF9 mRNA expression values, FGFR1 CNV values and mutation status of TCGA lung adenocarcinomas and squamous cell carcinomas.
View article: Supplementary Table 5 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies
Supplementary Table 5 from FGFR1 mRNA and Protein Expression, not Gene Copy Number, Predict FGFR TKI Sensitivity across All Lung Cancer Histologies Open
XLSX file - 106KB, Table S5. Tabulated FGFR1, FGF2 and FGF9 mRNA expression values, FGFR1 CNV values and mutation status of TCGA lung adenocarcinomas and squamous cell carcinomas.
View article: Diagnostic Accuracy of Arterial Spin Labeling MR Imaging in Detecting Residual Cerebral Arteriovenous Malformations Following Stereotactic Radiosurgery: A Systematic Review and Meta-Analysis
Diagnostic Accuracy of Arterial Spin Labeling MR Imaging in Detecting Residual Cerebral Arteriovenous Malformations Following Stereotactic Radiosurgery: A Systematic Review and Meta-Analysis Open
View article: Risk Factors for Delayed Cerebral Ischemia in Good‐Grade Patients With Aneurysmal Subarachnoid Hemorrhage
Risk Factors for Delayed Cerebral Ischemia in Good‐Grade Patients With Aneurysmal Subarachnoid Hemorrhage Open
Background A subset of good‐grade patients with aneurysmal subarachnoid hemorrhage (aSAH) develop delayed cerebral ischemia (DCI) that may cause permanent disabilities after aSAH. However, little is known about the risk factors of DCI amon…
View article: Deploying deep learning models on unseen medical imaging using adversarial domain adaptation
Deploying deep learning models on unseen medical imaging using adversarial domain adaptation Open
The fundamental challenge in machine learning is ensuring that trained models generalize well to unseen data. We developed a general technique for ameliorating the effect of dataset shift using generative adversarial networks (GANs) on a d…
View article: The Impact of Obstructive Sleep Apnea on Clinical, Perioperative, and Cost Outcomes in Patients Who Underwent Posterior Cervical Decompression and Fusion: A Single-Center Retrospective Analysis From 2008 to 2016
The Impact of Obstructive Sleep Apnea on Clinical, Perioperative, and Cost Outcomes in Patients Who Underwent Posterior Cervical Decompression and Fusion: A Single-Center Retrospective Analysis From 2008 to 2016 Open
BACKGROUND: Obstructive sleep apnea (OSA) is a pervasive problem that can result in diminished neurocognitive performance, increased risk of all-cause mortality, and significant cardiovascular disease. While previous studies have examined …
View article: Genome Wide Association of Many Diverse Phenotypes in Nitrogen Limited Field Conditions
Genome Wide Association of Many Diverse Phenotypes in Nitrogen Limited Field Conditions Open
Nitrogen inputs can be an important cost consideration for farmers in terms of economic profit as well as environmental impact. Elucidating genetic regions that are associated with plant phenotype response to nitrogen stress can help in fa…
View article: IDH-mutant astrocytoma with EGFR amplification—Genomic profiling in four cases and review of literature
IDH-mutant astrocytoma with EGFR amplification—Genomic profiling in four cases and review of literature Open
EGFR amplification is associated with aggressive glioma behavior and regarded as a molecular feature of glioblastoma. Although rare, IDH-mutant astrocytomas with EGFR amplification exist but remain poorly understood. We report the clinical…
View article: Bilateral Endoscopic Intracerebral Hemorrhage Evacuations at Two Separate Time Points: A Case Report
Bilateral Endoscopic Intracerebral Hemorrhage Evacuations at Two Separate Time Points: A Case Report Open
View article: Genome Wide Association of Many Diverse Phenotypes in Nitrogen Limited Field Conditions
Genome Wide Association of Many Diverse Phenotypes in Nitrogen Limited Field Conditions Open
Earth and Space Science Open Archive Presented WorkOpen AccessYou are viewing an older version [v1]Go to new versionGenome Wide Association of Many Diverse Phenotypes in Nitrogen Limited Field ConditionsAuthorsCollinLuebbertiDAndrewLeakeyi…
View article: Student Survey Results of a Virtual Medical Student Course Developed as a Platform for Neurosurgical Education During the Coronavirus Disease 2019 Pandemic
Student Survey Results of a Virtual Medical Student Course Developed as a Platform for Neurosurgical Education During the Coronavirus Disease 2019 Pandemic Open
View article: Statistical Analysis of Aneurysmal Subarachnoid Hemorrhage Trials
Statistical Analysis of Aneurysmal Subarachnoid Hemorrhage Trials Open
Background : Many randomized controlled trials (RCT) have assessed new treatments in subarachnoid hemorrhage (SAH), yet most show no treatment efficacy. One explanation is the statistical analysis of the primary endpoint was not as efficie…
View article: Deep anomaly detection of seizures with paired stereoelectroencephalography and video recordings
Deep anomaly detection of seizures with paired stereoelectroencephalography and video recordings Open
View article: Cervical Spine Alignment in the Sagittal Axis: A Review of the Best Validated Measures in Clinical Practice
Cervical Spine Alignment in the Sagittal Axis: A Review of the Best Validated Measures in Clinical Practice Open
Study Design: Review of the best-validated measures of cervical spine alignment in the sagittal axis. Objective: Describe the C2-C7 Cobb Angle, C2-C7 sagittal vertical axis, chin-brow to vertical angle, T1 slope minus C2-C7 lordosis, C2 sl…
View article: Correction to: Adult spinal deformity surgery: the effect of surgical start time on patient outcomes and cost of care
Correction to: Adult spinal deformity surgery: the effect of surgical start time on patient outcomes and cost of care Open
View article: Assessing the Impact of Neurogenic Claudication on Outcomes Following Decompression With Lumbar Interbody Fusions in Patients With Lumbar Spinal Stenosis
Assessing the Impact of Neurogenic Claudication on Outcomes Following Decompression With Lumbar Interbody Fusions in Patients With Lumbar Spinal Stenosis Open
Study Design: Retrospective cohort study. Objectives: To conduct the first comprehensive national-level study examining specific risks, outcomes, and costs surrounding surgical treatment of lumar spinal stenosis (LSS) in patients with and …
View article: Testing the Retroelement Invasion Hypothesis for the Emergence of the Ancestoral Eukaryotic Cell
Testing the Retroelement Invasion Hypothesis for the Emergence of the Ancestoral Eukaryotic Cell Open