Michael L. Volk
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View article: The Basics of Metabolic Dysfunction–Associated Steatotic Liver Disease for Cardiologists
The Basics of Metabolic Dysfunction–Associated Steatotic Liver Disease for Cardiologists Open
View article: Portal vein thrombosis in patients with cirrhosis
Portal vein thrombosis in patients with cirrhosis Open
Among patients with cirrhosis, PVT is independently associated with a higher risk of mortality, bleeding, and hospitalization. Anticoagulation may improve overall survival but is associated with a higher risk of bleeding and hospitalizatio…
View article: Pre-left ventricular assist device endoscopic evaluation does not reduce the risk of later gastrointestinal bleeding: a multicenter study
Pre-left ventricular assist device endoscopic evaluation does not reduce the risk of later gastrointestinal bleeding: a multicenter study Open
Our study suggests that pre-LVAD endoscopy is associated with a higher risk of GIB post LVAD, despite controlling for confounders. While this was an observational study and may not have captured all confounders, it appears that endoscopic …
View article: The liver frailty index is a predictor of healthcare utilization after liver transplantation in older adults
The liver frailty index is a predictor of healthcare utilization after liver transplantation in older adults Open
Background Older adults have higher healthcare utilization after liver transplantation (LT), yet objective risk stratification tools in this population are lacking. We evaluated the Liver Frailty Index (LFI) as one potential tool. Methods …
View article: Association of body mass index with post‐liver transplant outcomes
Association of body mass index with post‐liver transplant outcomes Open
Background Patients with obesity have inferior outcomes after general surgery procedures, but studies evaluating post‐liver transplant (LT) outcomes have been limited by small sample sizes or lack of granularity of outcomes. We evaluated t…
View article: Association of Frailty With Health-Related Quality of Life in Liver Transplant Recipients
Association of Frailty With Health-Related Quality of Life in Liver Transplant Recipients Open
Importance Frailty has been recognized as a risk factor for mortality after liver transplant (LT) but little is known of its association with functional status and health-related quality of life (HRQL), termed global functional health , in…
View article: Interhospital transfers resulting in liver transplantation: Clinical, regulatory, and economic issues
Interhospital transfers resulting in liver transplantation: Clinical, regulatory, and economic issues Open
Content available: Audio Recording.
View article: The clinical value of angiopoietin‐2 in liver diseases
The clinical value of angiopoietin‐2 in liver diseases Open
Content available: Audio Recording.
View article: Loneliness in adults awaiting liver transplantation at 7 U.S. transplant centers
Loneliness in adults awaiting liver transplantation at 7 U.S. transplant centers Open
View article: Updates in Telemedicine for Gastroenterology Practices in the United States
Updates in Telemedicine for Gastroenterology Practices in the United States Open
View article: Frailty, mortality, and health care utilization after liver transplantation: From the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study
Frailty, mortality, and health care utilization after liver transplantation: From the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study Open
Background and Aims Frailty is a well‐established risk factor for poor outcomes in patients with cirrhosis awaiting liver transplantation (LT), but whether it predicts outcomes among those who have undergone LT is unknown. Approach and Res…
View article: Quality measures in HCC care by the Practice Metrics Committee of the American Association for the Study of Liver Diseases
Quality measures in HCC care by the Practice Metrics Committee of the American Association for the Study of Liver Diseases Open
The burden of HCC is substantial. To address gaps in HCC care, the American Association for the Study of Liver Diseases (AASLD) Practice Metrics Committee (PMC) aimed to develop a standard set of process‐based measures and patient‐reported…
View article: Palliative Care Always: Hepatology—Virtual Primary Palliative Care Training for Hepatologists
Palliative Care Always: Hepatology—Virtual Primary Palliative Care Training for Hepatologists Open
Palliative care (PC) benefits patients with serious illness including end‐stage liver disease (ESLD). As part of a cluster randomized trial, hepatologists were trained to deliver primary palliative care to patients with ESLD using an onlin…
View article: Physical Activity Patterns in Frail and Nonfrail Patients With End-Stage Liver Disease
Physical Activity Patterns in Frail and Nonfrail Patients With End-Stage Liver Disease Open
View article: Frailty and the Risk of Acute Kidney Injury Among Patients With Cirrhosis
Frailty and the Risk of Acute Kidney Injury Among Patients With Cirrhosis Open
Acute kidney injury (AKI) and frailty are major drivers of outcomes among patients with cirrhosis. What is unknown is the impact of physical frailty on the development of AKI. We included adults with cirrhosis without hepatocellular carcin…
View article: Acute Liver Injury in Patients Hospitalized with COVID-19
Acute Liver Injury in Patients Hospitalized with COVID-19 Open
View article: Cognitive Impairment and Physical Frailty in Patients With Cirrhosis
Cognitive Impairment and Physical Frailty in Patients With Cirrhosis Open
Physical frailty and impaired cognition are common in patients with cirrhosis. Physical frailty can be assessed using performance‐based tests, but the extent to which impaired cognition may impact performance is not well characterized. We …
View article: The relationship between frailty and cirrhosis etiology: From the Functional Assessment in Liver Transplantation (FrAILT) Study
The relationship between frailty and cirrhosis etiology: From the Functional Assessment in Liver Transplantation (FrAILT) Study Open
Background & Aims Cirrhosis leads to malnutrition and muscle wasting that manifests as frailty, which may be influenced by cirrhosis aetiology. We aimed to characterize the relationship between frailty and cirrhosis aetiology. Methods Incl…
View article: Preventive Care in Adult Liver Transplant Recipients
Preventive Care in Adult Liver Transplant Recipients Open
Content available: Audio Recording Orthotropic liver transplant is a high-risk surgery with a roughly 10% mortality rate within the first year. However, among the 90% of patients who survive, the majority of their future morbidity and mort…
View article: Liver Transplantation for T2 Hepatocellular Carcinoma during the COVID-19 Pandemic: A Novel Model Balancing Individual Benefit against Healthcare Resources
Liver Transplantation for T2 Hepatocellular Carcinoma during the COVID-19 Pandemic: A Novel Model Balancing Individual Benefit against Healthcare Resources Open
The COVID-19 pandemic caused temporary drops in the supply of organs for transplantation, leading to renewed debate about whether T2 hepatocellular carcinoma (HCC) patients should receive priority during these times. The aim of this study …
View article: Liver Transplantation during the COVID-19 pandemic: A quantitative model balancing individual patient benefit against population healthcare needs
Liver Transplantation during the COVID-19 pandemic: A quantitative model balancing individual patient benefit against population healthcare needs Open
View article: Bariatric surgery and the risk of alcohol‐related cirrhosis and alcohol misuse
Bariatric surgery and the risk of alcohol‐related cirrhosis and alcohol misuse Open
Background & Aims Bariatric surgery is common, but alcohol misuse has been reported following these procedures. We aimed to determine if bariatric surgery is associated with increased risk of alcohol‐related cirrhosis (AC) and alcohol misu…
View article: Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: A Patient‐Friendly Summary of the 2019 AASLD Guidelines
Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: A Patient‐Friendly Summary of the 2019 AASLD Guidelines Open
Watch a video presentation of this article This article will summarize practice guidance/guidelines put forth by the American Association for the Study of Liver Diseases (AASLD) in an easy-to-read format for patients and their caregivers. …
View article: Rejuveinix Mitigates Sepsis-Associated Oxidative Stress in the Brain of Mice: Clinical Impact Potential in COVID-19 and Nervous System Disorders
Rejuveinix Mitigates Sepsis-Associated Oxidative Stress in the Brain of Mice: Clinical Impact Potential in COVID-19 and Nervous System Disorders Open
Here, we demonstrate that our anti-sepsis and COVID-19 drug candidate Rejuveinix (RJX) substantially improves the survival outcome in the LPS-GalN animal model of sepsis and multi-organ failure. One hundred (100) percent (%) of untreated c…
View article: Hospitalizations and healthcare costs associated with rifaximin versus lactulose treatment among commercially insured patients with hepatic encephalopathy in the United States
Hospitalizations and healthcare costs associated with rifaximin versus lactulose treatment among commercially insured patients with hepatic encephalopathy in the United States Open
The study is subject to limitations common to claims-based analyses.
View article: Association of Frailty and Sex With Wait List Mortality in Liver Transplant Candidates in the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study
Association of Frailty and Sex With Wait List Mortality in Liver Transplant Candidates in the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study Open
These findings demonstrate that women with cirrhosis display worse frailty scores than men despite similar MELDNa scores. The higher risk of wait list mortality that women experienced appeared to be explained in part by frailty.
View article: Association Between Preadmission Acid Suppressive Medication Exposure and Severity of Illness in Patients Hospitalized With COVID-19
Association Between Preadmission Acid Suppressive Medication Exposure and Severity of Illness in Patients Hospitalized With COVID-19 Open
View article: Digestive Manifestations in Patients Hospitalized With Coronavirus Disease 2019
Digestive Manifestations in Patients Hospitalized With Coronavirus Disease 2019 Open
View article: Digestive Manifestations in Patients Hospitalized with COVID-19
Digestive Manifestations in Patients Hospitalized with COVID-19 Open
Background The prevalence and significance of digestive manifestations in COVID-19 remain uncertain. Methods Consecutive patients hospitalized with COVID-19 were identified across a geographically diverse alliance of medical centers in Nor…
View article: Identifying an Optimal Liver Frailty Index Cutoff to Predict Waitlist Mortality in Liver Transplant Candidates
Identifying an Optimal Liver Frailty Index Cutoff to Predict Waitlist Mortality in Liver Transplant Candidates Open
Background and Aims Frailty, as measured by the Liver Frailty Index (LFI), is associated with liver transplant (LT) waitlist mortality. We sought to identify an optimal LFI cutoff that predicts waitlist mortality. Approach and Results Adul…