Michael Wong
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View article: Chronic oral cannabidiol delays or prevents seizures in a mouse model of CLN2 disease
Chronic oral cannabidiol delays or prevents seizures in a mouse model of CLN2 disease Open
A growing body of literature describes the anti-inflammatory, neuroprotective, and anti-epileptic properties of the cannabis sativa constituent cannabidiol, suggesting that it might play a useful role in the treatment of neurodegenerative …
View article: Persistence of vestibular function in the absence of glutamatergic transmission from hair cells
Persistence of vestibular function in the absence of glutamatergic transmission from hair cells Open
Quantal synaptic transmission in vestibular end-organs is glutamatergic. Although genetic deletion of Slc17a8 (termed Vglut3 ) leads to deafness in mice, the dependence of vestibular function on VGLUT3-mediated quantal transmission is unkn…
View article: GABAergic interneurons contribute to the fatal seizure phenotype of CLN2 disease mice
GABAergic interneurons contribute to the fatal seizure phenotype of CLN2 disease mice Open
The cellular etiology of seizures in CLN2 disease, a childhood-onset neurodegenerative lysosomal storage disorder caused by a deficiency of tripeptidyl peptidase 1 (TPP1), remains elusive. Given that Cln2R207X/R207X mice display fatal spon…
View article: Enteric Disease Outbreaks Associated with Animal Contact — Animal Contact Outbreak Surveillance System, United States, 2009–2021
Enteric Disease Outbreaks Associated with Animal Contact — Animal Contact Outbreak Surveillance System, United States, 2009–2021 Open
Public health partners should continue to report animal contact outbreaks through ACOSS to inform evidence-based interventions tailored to specific animals, pathogens, populations, and settings. Strengthening the capacity of local, state, …
View article: A Role for δ Subunit-Containing GABA <sub>A</sub> Receptors on Parvalbumin-Positive Neurons in Maintaining Electrocortical Signatures of Sleep States
A Role for δ Subunit-Containing GABA <sub>A</sub> Receptors on Parvalbumin-Positive Neurons in Maintaining Electrocortical Signatures of Sleep States Open
GABA A receptors containing δ subunits have been shown to mediate tonic/slow inhibition in the CNS. These receptors are typically found extrasynaptically and are activated by relatively low levels of ambient GABA in the extracellular space…
View article: 3D-Printed Coronary Arteries: An Effective Tool in Medical Education
3D-Printed Coronary Arteries: An Effective Tool in Medical Education Open
View article: Lemborexant, a Dual Orexin Receptor Antagonist, ameliorates Tau‐mediated Sleep Loss and Neurodegeneration
Lemborexant, a Dual Orexin Receptor Antagonist, ameliorates Tau‐mediated Sleep Loss and Neurodegeneration Open
Background Sleep disturbances are associated with the pathogenesis of neurodegenerative diseases including Alzheimer’s disease (AD) and primary tauopathies. We have previously shown that APOE4, the strongest genetic risk factor for AD, dir…
View article: A role of dentate gyrus mechanistic target of rapamycin activation in epileptogenesis in a mouse model of posttraumatic epilepsy
A role of dentate gyrus mechanistic target of rapamycin activation in epileptogenesis in a mouse model of posttraumatic epilepsy Open
Objective The mechanistic target of rapamycin (mTOR) pathway has been implicated in promoting epileptogenesis in animal models of acquired epilepsy, such as posttraumatic epilepsy (PTE) following traumatic brain injury (TBI). However, the …
View article: GABAergic interneurons contribute to the fatal seizure phenotype of CLN2 disease mice
GABAergic interneurons contribute to the fatal seizure phenotype of CLN2 disease mice Open
GABAergic interneuron deficits have been implicated in the epileptogenesis of multiple neurological diseases. While epileptic seizures are a key clinical hallmark of CLN2 disease, a childhood-onset neurodegenerative lysosomal storage disor…
View article: A role for δ subunit-containing GABA<sub>A</sub>receptors on parvalbumin positive neurons in maintaining electrocortical signatures of sleep states
A role for δ subunit-containing GABA<sub>A</sub>receptors on parvalbumin positive neurons in maintaining electrocortical signatures of sleep states Open
GABA A receptors containing δ subunits have been shown to mediate tonic/slow inhibition in the CNS. These receptors are typically found extrasynaptically and are activated by relatively low levels of ambient GABA in the extracellular space…
View article: Periodic and aperiodic changes to cortical EEG in response to pharmacological manipulation
Periodic and aperiodic changes to cortical EEG in response to pharmacological manipulation Open
Neuropsychiatric illness may be associated with altered excitation/inhibition balance. A single electroencephalogram (EEG) parameter, the aperiodic exponent of power spectra, may predict the ratio between excitation and inhibition. Here, w…
View article: Drug Resistant Epilepsy in Tuberous Sclerosis Complex is Associated with Tsc2 Genotype: More Findings from the Prevent Trial
Drug Resistant Epilepsy in Tuberous Sclerosis Complex is Associated with Tsc2 Genotype: More Findings from the Prevent Trial Open
View article: Cerebral vascular and blood brain–barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex
Cerebral vascular and blood brain–barrier abnormalities in a mouse model of epilepsy and tuberous sclerosis complex Open
Objective Tuberous sclerosis complex (TSC) is a genetic disorder, characterized by tumor formation in the brain and other organs, and severe neurological symptoms, such as epilepsy. Abnormal vascular endothelial growth factor (VEGF) expres…
View article: Spatial and amplitude dynamics of neurostimulation: Insights from the acute intrahippocampal kainate seizure mouse model
Spatial and amplitude dynamics of neurostimulation: Insights from the acute intrahippocampal kainate seizure mouse model Open
Objective Neurostimulation is an emerging treatment for patients with drug‐resistant epilepsy, which is used to suppress, prevent, and terminate seizure activity. Unfortunately, after implantation and despite best clinical practice, most p…
View article: Periodic and aperiodic changes to cortical EEG in response to pharmacological manipulation
Periodic and aperiodic changes to cortical EEG in response to pharmacological manipulation Open
Cortical electroencephalograms (EEG) may help understanding of neuropsychiatric illness and new treatment mechanisms. The aperiodic component (1/ f ) of EEG power spectra is often treated as noise, but recent studies suggest that changes t…
View article: Early Treatment with Vigabatrin Does Not Decrease Focal Seizures or Improve Cognition in Tuberous Sclerosis Complex: The <scp>PREVeNT</scp> Trial
Early Treatment with Vigabatrin Does Not Decrease Focal Seizures or Improve Cognition in Tuberous Sclerosis Complex: The <span>PREVeNT</span> Trial Open
Objective This study was undertaken to test the hypothesis that early vigabatrin treatment in tuberous sclerosis complex (TSC) infants improves neurocognitive outcome at 24 months of age. Methods A phase IIb multicenter randomized double‐b…
View article: Participant- and Disease-Related Factors as Independent Predictors of Treatment Outcomes in the RESTORE-IMI 2 Clinical Trial: A Multivariable Regression Analysis
Participant- and Disease-Related Factors as Independent Predictors of Treatment Outcomes in the RESTORE-IMI 2 Clinical Trial: A Multivariable Regression Analysis Open
Background In the RESTORE-IMI 2 trial, imipenem/cilastatin/relebactam (IMI/REL) was noninferior to piperacillin/tazobactam in treating hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia. This post hoc analysis …
View article: Gene therapy ameliorates spontaneous seizures associated with cortical neuron loss in a Cln2R207X mouse model
Gene therapy ameliorates spontaneous seizures associated with cortical neuron loss in a Cln2R207X mouse model Open
Although a disease-modifying therapy for classic late infantile neuronal ceroid lipofuscinosis (CLN2 disease) exists, poor understanding of cellular pathophysiology has hampered the development of more effective and persistent therapies. H…
View article: Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a <i>TREM2</i> -dependent manner in mice
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a <i>TREM2</i> -dependent manner in mice Open
Sleep loss is associated with cognitive decline in the aging population and is a risk factor for Alzheimer’s disease (AD). Considering the crucial role of immunomodulating genes such as that encoding the triggering receptor expressed on my…
View article: Sleep–wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice
Sleep–wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice Open
Old animals display significant alterations in sleep–wake patterns such as increases in sleep fragmentation and sleep propensity. Here, we demonstrated that PR-domain containing protein 13 (Prdm13)+ neurons in the dorsomedial hypothalamus …
View article: Spatial and Amplitude Dynamics of Neurostimulation: Insights from the Acute Intrahippocampal Kainate Seizure Mouse Model
Spatial and Amplitude Dynamics of Neurostimulation: Insights from the Acute Intrahippocampal Kainate Seizure Mouse Model Open
Objective Neurostimulation is an emerging treatment for patients with medically refractory epilepsy, which is used to suppress, prevent, and terminate seizure activity. Unfortunately, after implantation and despite best clinical practice, …
View article: Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restriction in mice
Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restriction in mice Open
Old animals display significant alterations in sleep-wake patterns such as increases in sleep fragmentation and sleep propensity. Here we demonstrated that dorsomedial hypothalamus-specific PR-domain containing protein 13 -knockout (DMH- P…
View article: Non-sedative cortical EEG signatures of allopregnanolone and functional comparators
Non-sedative cortical EEG signatures of allopregnanolone and functional comparators Open
View article: Functional neuropathology of neonatal hypoxia‐ischemia by single‐mouse longitudinal electroencephalography
Functional neuropathology of neonatal hypoxia‐ischemia by single‐mouse longitudinal electroencephalography Open
Objective Neonatal cerebral hypoxia‐ischemia (HI) results in symptomatic seizures and long‐term neurodevelopmental disability. The Rice‐Vannucci model of rodent neonatal HI has been used extensively to examine and translate the functional …
View article: Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures
Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures Open
View article: Performance in Fundamentals of Laparoscopic Surgery (FLS): Does it Reflect Global Rating Scales in Objective Structured Assessment of Technical Skills (OSATS) in Porcine Laparoscopic Surgery?
Performance in Fundamentals of Laparoscopic Surgery (FLS): Does it Reflect Global Rating Scales in Objective Structured Assessment of Technical Skills (OSATS) in Porcine Laparoscopic Surgery? Open
Background To correlate the utility of Fundamentals of Laparoscopic Surgery (FLS) manual skills program with the Objective Structured Assessment of Technical Skills (OSATS) global rating scale in evaluating operative performance. Materials…
View article: Commentary on “The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia”
Commentary on “The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia” Open
Drug-resistant epilepsy remains one of the most challenging and impairing problems facing epilepsy patients. In the large population of patients with drug-resistant epilepsy, nonmedical treatments, especially epilepsy surgery, may offer th…
View article: Cortical interneuron loss and seizure generation as novel clinically relevant disease phenotypes in <i>Cln2<sup>R207X</sup></i> mice
Cortical interneuron loss and seizure generation as novel clinically relevant disease phenotypes in <i>Cln2<sup>R207X</sup></i> mice Open
Aims CLN2 disease is a fatal inherited childhood neurodegenerative disorder. Although a disease-modifying therapy now exists, a fundamental lack of understanding of disease pathogenesis has hampered development of more effective therapies.…
View article: Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures
Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures Open
Cannabidiol (CBD) has gained attention as a therapeutic agent and is purported to have immunomodulatory, neuroprotective, and anti-seizure effects. Here, we determined the effects of chronic CBD administration in a mouse model of CLN1 dise…
View article: Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex
Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex Open