Michael Linscheid
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View article: Computer-Assisted HPLC Method Development Using DryLab for Determination of Major Phenolic Components in Corchorus olitorius and Vitis vinifera by using HPLC-PDA-ESI-TOF- MSn
Computer-Assisted HPLC Method Development Using DryLab for Determination of Major Phenolic Components in Corchorus olitorius and Vitis vinifera by using HPLC-PDA-ESI-TOF- MSn Open
Computer–assisted HPLC method development is a tool that uses Design-ofExperiment techniques to optimize HPLC methods with minimal time and cost, especially for complex mixtures like natural extracts. Corchorus olitorius and Vitis vinifera…
View article: Origanum majorana L. protects against neuroinflammation-mediated cognitive impairment: a phyto-pharmacological study
Origanum majorana L. protects against neuroinflammation-mediated cognitive impairment: a phyto-pharmacological study Open
Background Neuroinflammation and oxidative stress are critical players in the pathogenesis of numerous neurodegenerative diseases, such as Alzheimer’s disease (AD) which is responsible for most cases of dementia in the elderly. With the la…
View article: METASPACE: A community-populated knowledge base of spatial metabolomes in health and disease
METASPACE: A community-populated knowledge base of spatial metabolomes in health and disease Open
Metabolites, lipids, and other small molecules are key constituents of tissues supporting cellular programs in health and disease. Here, we present METASPACE, a community-populated knowledge base of spatial metabolomes from imaging mass sp…
View article: Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice
Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice Open
Lung cancer has one of the highest mortality rates among various types of cancer and is the most frequent cancer in the world. The incidence of lung cancer is increasing rapidly, in parallel with an increased incidence of smoking. Effectiv…
View article: Gadolinium in human brain sections and colocalization with other elements
Gadolinium in human brain sections and colocalization with other elements Open
Recent recommendations by the Food and Drug Administration1 and the European Medicines Agency2 are to limit the clinical use of linear gadolinium-based contrast agents (GBCAs) due to convincing evidence of deposition in tissues. Macrocycli…
View article: Characterization of hepatoprotective metabolites from Artemisia annua and Cleome droserifolia using HPLC/PDA/ESI/MS–MS
Characterization of hepatoprotective metabolites from Artemisia annua and Cleome droserifolia using HPLC/PDA/ESI/MS–MS Open
The hepatoprotective activities of two traditionally used plants, Cleome droserifolia (Forssk.) Delile, Cleomaceae, and Artemisia annua L., Asteraceae, were recently reported. However, the biologically active metabolites responsible for th…
View article: Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity
Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity Open
Nephrotoxicity is a major limitation to cisplatin antitumor therapies. Cilastatin, an inhibitor of renal dehydropeptidase-I, was recently proposed as a promising nephroprotector against cisplatin toxicity, preventing apoptotic cell death. …
View article: Polyphenols from Tamarix nilotica: LC–ESI-MSn Profiling and In Vivo Antifibrotic Activity
Polyphenols from Tamarix nilotica: LC–ESI-MSn Profiling and In Vivo Antifibrotic Activity Open
Tamarix nilotica (Ehrenb.) Bunge (Tamaricaceae), an indigenous plant to the Middle East region, is well-known as a medicinal plant for treating many human ailments. The current study aimed at exploring the polyphenol profile of the alcohol…
View article: Polyphenols from <em>Tamarix nilotica</em>: LC&ndash;ESI-MSn Profiling and <em>In-Vivo</em> Antifibrotic Activity
Polyphenols from <em>Tamarix nilotica</em>: LC–ESI-MSn Profiling and <em>In-Vivo</em> Antifibrotic Activity Open
Tamarix nilotica (Ehrenb.) Bunge (Tamaricaceae), an indigenous plant to the Middle East region, is well-known as a medicinal plant for treating many human ailments. The current study aimed at exploring the polyphenols profile of T.nilotica…
View article: Identification and Characterization of Differentially-Regulated Type IVb Pilin Genes Necessary for Predation in Obligate Bacterial Predators
Identification and Characterization of Differentially-Regulated Type IVb Pilin Genes Necessary for Predation in Obligate Bacterial Predators Open
Bdellovibrio bacteriovorus is an obligate predator of bacteria that grows and divides within the periplasm of its prey. Functions involved in the early steps of predation have been identified and characterized, but mediators of prey invasi…
View article: Detection of sulfenic acid in intact proteins by mass spectrometric techniques: application to serum samples
Detection of sulfenic acid in intact proteins by mass spectrometric techniques: application to serum samples Open
A new developed strategy for the specific detection and quantification of cysteine sulfenic acid (SA) using molecular and elemental mass spectrometric (MS) techniques.
View article: Identification of phenolic secondary metabolites from <i>Schotia brachypetala</i> Sond. (Fabaceae) and demonstration of their antioxidant activities in <i>Caenorhabditis elegans</i>
Identification of phenolic secondary metabolites from <i>Schotia brachypetala</i> Sond. (Fabaceae) and demonstration of their antioxidant activities in <i>Caenorhabditis elegans</i> Open
Background Schotia brachypetala Sond. (Fabaceae) is an endemic tree of Southern Africa whose phytochemistry and pharmacology were slightly studied. The present work aimed at profiling the major phenolics compounds present in the hydro-alco…
View article: Identification of phenolic secondary metabolites from<i> Schotia brachypetala</i> Sond. (Fabaceae) and demonstration of their antioxidant activities in <i>Caenorhabditis elegans</i>
Identification of phenolic secondary metabolites from<i> Schotia brachypetala</i> Sond. (Fabaceae) and demonstration of their antioxidant activities in <i>Caenorhabditis elegans</i> Open
Background: Schotia brachypetala Sond. (Fabaceae) is an endemic tree of Southern Africa whose phytochemistry and pharmacology were slightly studied.The present work aimed at profiling the major phenolics compounds present in the hydro-alco…
View article: Identification of phenolic secondary metabolites from <i>Schotia brachypetala</i> Sond. (Fabaceae) and demonstration of their antioxidant activities in <i>Caenorhabditis elegans</i>
Identification of phenolic secondary metabolites from <i>Schotia brachypetala</i> Sond. (Fabaceae) and demonstration of their antioxidant activities in <i>Caenorhabditis elegans</i> Open
Background: Schotia brachypetala Sond. (Fabaceae) is an endemic tree of Southern Africa whose phytochemistry and pharmacology were slightly studied.The present work aimed at profiling the major phenolics compounds present in the hydro-alco…
View article: Acylated flavonol diglucosides from <i>Ammania auriculata</i>
Acylated flavonol diglucosides from <i>Ammania auriculata</i> Open
Chemical investigation of the extract of the whole Ammania auriculata plant resulted in the identification of 13 polyphenols, including the hitherto unknown flavonoids, kaempferol 3- O -β-(6″-galloylglucopyranoside)-7- O -β-glucopyranoside…