Michael R. Levitt
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View article: Assessing the Accuracy of Artificial Intelligence in Detecting Intracranial Aneurysms in a Clinical Setting Relative to Neuroradiologists
Assessing the Accuracy of Artificial Intelligence in Detecting Intracranial Aneurysms in a Clinical Setting Relative to Neuroradiologists Open
Our multisite study showed that neuroradiologists performed better than AI for IA detection in terms of sensitivity and accuracy, while while achieving comparable specificity.
View article: Single-session versus staged approaches for chronic subdural hematoma treatment with middle meningeal artery embolization and evacuation surgery: a propensity score–matched analysis
Single-session versus staged approaches for chronic subdural hematoma treatment with middle meningeal artery embolization and evacuation surgery: a propensity score–matched analysis Open
OBJECTIVE Surgical evacuation is the mainstay of treatment for patients with chronic subdural hematoma (cSDH) who have symptomatic mass effect, yet it carries a recurrence risk of up to 20%. Recent randomized trials have shown that adding …
View article: Predicting Vasospasm and Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage: The Role of Vessel Wall MRI
Predicting Vasospasm and Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage: The Role of Vessel Wall MRI Open
aSAH= Aneurysmal Subarachnoid Hemorrhage. ASVWE= Adjusted Segmental Vessel Wall Enhancement. DCI= Delayed Cerebral Ischemia. DI= Delayed Infarction. IA= Intracranial Aneurysm. IVWM= Intracranial Vessel Wall MRI. mFisher= Modified Fisher Gr…
View article: Low‐Allele‐Frequency Somatic Variants in a Cohort of Sporadic Saccular “Berry” Cerebral Aneurysms
Low‐Allele‐Frequency Somatic Variants in a Cohort of Sporadic Saccular “Berry” Cerebral Aneurysms Open
Background Subarachnoid hemorrhage from ruptured saccular intracranial aneurysms (IAs) is fatal in ≈50% of cases. Significant effort has been devoted to identifying the molecular pathogenesis of IAs to develop new therapies to treat or hal…
View article: Minimally Invasive Surgery vs Medical Management Alone for Intracerebral Hemorrhage
Minimally Invasive Surgery vs Medical Management Alone for Intracerebral Hemorrhage Open
Importance It remains uncertain whether surgical evacuation improves functional outcomes in patients with supratentorial intracerebral hemorrhage (ICH). Objective To compare the safety and efficacy of minimally invasive surgery with the Ar…
View article: Conventional versus advanced imaging selection for endovascular treatment of basilar artery occlusion strokes
Conventional versus advanced imaging selection for endovascular treatment of basilar artery occlusion strokes Open
Introduction: Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed …
View article: Outcomes after carotid revascularization for symptomatic carotid artery web: A multi-institutional cohort study
Outcomes after carotid revascularization for symptomatic carotid artery web: A multi-institutional cohort study Open
Objective Carotid web can serve as a nidus for clot formation and subsequent thromboembolic stroke. Although treatment historically involved antiplatelet therapy, recent evidence demonstrates notably elevated recurrent stroke rates despite…
View article: Concurrent Anterior Cerebral Artery and Middle Cerebral Artery Occlusions Predict Poor Neurological Outcome Despite Successful Thrombectomy in Anterior Circulation Stroke
Concurrent Anterior Cerebral Artery and Middle Cerebral Artery Occlusions Predict Poor Neurological Outcome Despite Successful Thrombectomy in Anterior Circulation Stroke Open
BACKGROUND AND OBJECTIVES: Despite successful endovascular thrombectomy for acute ischemic stroke, a significant proportion of patients demonstrate fast and early progression of infarct core and fail to achieve functional independence at 9…
View article: Dose Modeling for Mitochondrial Transplantation in Barrier-Limited Tissues
Dose Modeling for Mitochondrial Transplantation in Barrier-Limited Tissues Open
Mitochondrial transplantation is an emerging regenerative therapy aimed at preventing ischemia– reperfusion injury (IRI) by restoring oxidative metabolism in vulnerable tissues. While early clinical studies have demonstrated feasibility in…
View article: Hurting More Than Helping? Decompressive Craniectomy in Patients With Symptomatic Intracerebral Hemorrhage After Mechanical Thrombectomy in Acute Ischemic Stroke: Insights From Stroke Thrombectomy and Aneurysm Registry
Hurting More Than Helping? Decompressive Craniectomy in Patients With Symptomatic Intracerebral Hemorrhage After Mechanical Thrombectomy in Acute Ischemic Stroke: Insights From Stroke Thrombectomy and Aneurysm Registry Open
BACKGROUND AND OBJECTIVES: It remains unclear whether decompressive craniectomy (DC) is beneficial in patients who suffer symptomatic intracerebral hemorrhage (sICH) after acute ischemic stroke (AIS). We sought to study the effect of DC on…
View article: Periprocedural therapeutics do not impair extracellular mitochondrial viability in transplantation
Periprocedural therapeutics do not impair extracellular mitochondrial viability in transplantation Open
Mitochondrial transplantation is an emerging therapeutic approach for ischemia-reperfusion injury, offering the potential to restore cellular function through the engraftment of extracellular mitochondria. The successful clinical applicati…
View article: Silk Vista baby for the Treatment of Distal Anterior Cerebral Artery Aneurysms
Silk Vista baby for the Treatment of Distal Anterior Cerebral Artery Aneurysms Open
Purpose: Treating small-caliber vessel aneurysms with flow diverters presents challenges due to narrow luminal diameters and tortuous vasculature, which make navigation and deployment of conventional devices using standard microcatheters m…
View article: Effect of race on procedural and clinical outcomes in middle meningeal artery embolization for primary and adjunctive treatment of chronic subdural hematoma
Effect of race on procedural and clinical outcomes in middle meningeal artery embolization for primary and adjunctive treatment of chronic subdural hematoma Open
Background We investigated racial disparities in radiologic and clinical outcomes of patients after middle meningeal artery embolization (MMAE) for chronic subdural hematoma (CSDH) with or without evacuation surgery. Methods This multicent…
View article: International multi-center study of middle meningeal artery embolization for chronic subdural hematoma in cancer patients: Efficacy, safety, and outcomes in a high-risk population
International multi-center study of middle meningeal artery embolization for chronic subdural hematoma in cancer patients: Efficacy, safety, and outcomes in a high-risk population Open
Background Middle meningeal artery embolization (MMAE) is a promising treatment for chronic subdural hematoma (cSDH). Cancer patients are at risk for cSDH due to thrombocytopenia. The efficacy of MMAE in this population has not been studie…
View article: 1138 Gender, Inflammation, and Cognition Affect the Sleep Trajectories of Subarachnoid Hemorrhage Survivors
1138 Gender, Inflammation, and Cognition Affect the Sleep Trajectories of Subarachnoid Hemorrhage Survivors Open
Introduction Sleep disturbance after subarachnoid hemorrhage (SAH) impacts recovery and rehabilitation. Longitudinal studies examining trajectories of sleep are needed to understand patients’ experiences of sleep over time. We aimed to ide…
View article: Trends and disparities in ischemic stroke mortality and location of death in the United States: A comprehensive analysis from 1999–2020
Trends and disparities in ischemic stroke mortality and location of death in the United States: A comprehensive analysis from 1999–2020 Open
Background Stroke remains the fifth leading cause of mortality in the United States, with significant geographical and racial disparities in outcomes. Understanding trends in location of death for ischemic stroke patients is crucial for im…
View article: Viral Reactivation After Stroke: A Novel Model for Post-Stroke Depression
Viral Reactivation After Stroke: A Novel Model for Post-Stroke Depression Open
Background Post-stroke depression (PSD) is a common and debilitating complication of acute ischemic stroke (AIS), yet its biological basis remains unclear. AIS induces immune dysregulation and blood–brain barrier (BBB) disruption, which ma…
View article: The influence of prestroke disability on outcome in patients with a low Alberta Stroke Program Early CT Score who underwent endovascular thrombectomy
The influence of prestroke disability on outcome in patients with a low Alberta Stroke Program Early CT Score who underwent endovascular thrombectomy Open
OBJECTIVE The definitive influence of prestroke disability on outcomes in patients with a low Alberta Stroke Program Early CT Score (ASPECTS) treated with endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) due to large-vessel …
View article: Comparative efficacy and safety of stent retrievers as a bailout strategy following failed contact aspiration technique in acute stroke thrombectomy
Comparative efficacy and safety of stent retrievers as a bailout strategy following failed contact aspiration technique in acute stroke thrombectomy Open
Background The contact aspiration (CA) technique is often used to perform endovascular thrombectomy (EVT) for acute ischemic stroke (AIS); however, rescue strategies are necessary if CA fails to achieve recanalization. This study investiga…
View article: Mechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR
Mechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR Open
Background The elderly population (≥80 years) were underrepresented in recent trials of endovascular thrombectomy (EVT) for anterior circulation large vessel occlusion acute ischemic stroke (LVO-AIS) with low Alberta Stroke Program Early C…
View article: Radiolabeling isolated mitochondria with Tc-99m: A first-in-field protocol and early feasibility findings
Radiolabeling isolated mitochondria with Tc-99m: A first-in-field protocol and early feasibility findings Open
Mitochondrial transplantation is a promising but still experimental strategy for treating ischemic and metabolic disorders. A key barrier to its advancement is the lack of scalable, non-invasive methods for tracking transplanted extracellu…
View article: Platelet inhibition strategies in rescue stenting after failed thrombectomy: a large retrospective multicenter registry
Platelet inhibition strategies in rescue stenting after failed thrombectomy: a large retrospective multicenter registry Open
Background: Rescue stenting (RS) is a bailout strategy for failed thrombectomy. Optimal platelet inhibition strategy after RS remains unclear. Objectives: We aimed to describe and compare different platelet inhibition strategies during/aft…
View article: Flow-diverting stents for the treatment of unruptured distal anterior cerebral artery aneurysms: analysis of the CRETA Registry
Flow-diverting stents for the treatment of unruptured distal anterior cerebral artery aneurysms: analysis of the CRETA Registry Open
Background Data about the safety and the efficacy of flow diversion for distal anterior cerebral artery (DACA) aneurysms are limited. We present the largest multicenter analysis evaluating the outcomes of flow diversion in unruptured DACA …
View article: Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review
Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review Open
The results of a Phase 1 trial of autologous mitochondrial transplantation for the treatment of acute ischemic stroke during mechanical thrombectomy are presented. Standardized methods were used to isolate viable autologous mitochondria in…
View article: Smartphone-Based Pupillometry Using Machine Learning for the Diagnosis of Sports-Related Concussion
Smartphone-Based Pupillometry Using Machine Learning for the Diagnosis of Sports-Related Concussion Open
Background: Quantitative pupillometry has been proposed as an objective means to diagnose acute sports-related concussion (SRC). Objective: To assess the diagnostic accuracy of a smartphone-based quantitative pupillometer in the acute diag…
View article: Irregular pulsation on 4D-CTA and quantitative wall enhancement on VW-MRI are associated with symptoms of unruptured intracranial aneurysms
Irregular pulsation on 4D-CTA and quantitative wall enhancement on VW-MRI are associated with symptoms of unruptured intracranial aneurysms Open
Background Unruptured intracranial aneurysms (IAs) that become symptomatic have been associated with instability. Objective To investigate the relationship between irregular pulsation on four-dimensional CT angiography (4D-CTA) and aneurys…