Michael Markert
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View article: Pimobendan oral solution is bioequivalent to pimobendan chewable tablets in beagle dogs
Pimobendan oral solution is bioequivalent to pimobendan chewable tablets in beagle dogs Open
Background Myxomatous mitral valve disease (MMVD) is frequently diagnosed in small breed dogs. Pimobendan oral solution has been developed to improve dosing accuracy in small and toy breed dogs. Hypothesis/Objectives Demonstrate bioequival…
View article: Optimization of bioanalysis of dried blood samples
Optimization of bioanalysis of dried blood samples Open
Automated blood sampling systems have the potential to provide increased numbers of blood samples, providing substantially more Pharmacokinetic data within safety pharmacology studies without disrupting physiological parameters. They can p…
View article: The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies
The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies Open
This retrospective data base evaluation has demonstrated the impact of environmental and biological factors on cardiovascular parameters in the context of performing safety pharmacology studies. Breed, sex, age and the type of cage system …
View article: Comparison of statistical, machine learning, and mathematical modelling methods to investigate the effect of ageing on dog’s cardiovascular system
Comparison of statistical, machine learning, and mathematical modelling methods to investigate the effect of ageing on dog’s cardiovascular system Open
The aim of this work is to provide a preliminary comparison of different classes of methods to automatically detect the effect of ageing from in vivo data. The application which motivated this work is related to safety pharmacology, whose …
View article: The Biography of Specimen “09.04.1954, 3.4 mm” from the “Blechschmidt Collection of Human Embryos” at Göttingen University with a Special Focus on the Production and Usage of Enlarged 3D Replicas of Embryos in the Anatomical Research on Human Embryos
The Biography of Specimen “09.04.1954, 3.4 mm” from the “Blechschmidt Collection of Human Embryos” at Göttingen University with a Special Focus on the Production and Usage of Enlarged 3D Replicas of Embryos in the Anatomical Research on Human Embryos Open
The “Blechschmidt Collection of Human Embryos” housed at the Anatomical Institute of Göttingen University (Germany) is an important historical collection of human embryo specimens whose history dates back up to the mid-1940s. It is named a…
View article: Annals of the History and Philosophy of Biology 25/2020
Annals of the History and Philosophy of Biology 25/2020 Open
Scientific collections at universities are important resources for research, teaching, and education in their respective disciplines.Furthermore, during the last decades an interdisciplinary and supra-institutional discourse arose wherein …
View article: Ethical Aspects of Human Embryo Collections: A Historically Grounded Approach to the Blechschmidt Collection at the University of Göttingen
Ethical Aspects of Human Embryo Collections: A Historically Grounded Approach to the Blechschmidt Collection at the University of Göttingen Open
Human body donation and tissue collections are nowadays grounded on a legal framework centered around the concept of informed consent in most countries. Comparable regulations did not exist prior to the second half of the 20th century, whe…
View article: Staging nature in twentieth-century teacher education and classrooms
Staging nature in twentieth-century teacher education and classrooms Open
At the end of the nineteenth century, biology as an academic discipline was as young as its corresponding school subject. Now nature itself was analysed as a complex (eco)system consisting of animals, plants, and man. The dramatic conceptu…
View article: Investigation on the Ion Motion towards Clearing Electrodes in\n High-Brightness Electron Accelerators
Investigation on the Ion Motion towards Clearing Electrodes in\n High-Brightness Electron Accelerators Open
High-brightness electron beams provided by modern accelerators require\nseveral measures to preserve their high quality and to avoid instabilities. The\nmitigation of the impact of residual ions is one of these measures. It is\nparticularl…
View article: Investigation on the Ion Motion towards Clearing Electrodes in High-Brightness Electron Accelerators
Investigation on the Ion Motion towards Clearing Electrodes in High-Brightness Electron Accelerators Open
High-brightness electron beams provided by modern accelerators require several measures to preserve their high quality and to avoid instabilities. The mitigation of the impact of residual ions is one of these measures. It is particularly i…
View article: Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa
Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa Open
This meeting report is based on presentations given at the first Drug Safety Africa Meeting in Potchefstroom, South Africa from November 20-22, 2018 at the North-West University campus. There were 134 attendees (including 26 speakers and 3…
View article: Annals of the History and Philosophy of Biology 21/2016
Annals of the History and Philosophy of Biology 21/2016 Open
The mechanization of the world in the sixteenth and seventeenth centuries leads to the conviction of the regularity of nature and its processes and also calls for a theory of reproduction based on mechanical laws without the necessity of a…
View article: Cardiovascular safety pharmacology studies in dogs enabled for a poorly soluble molecule using spray-dried dispersion: Impact on lead selection
Cardiovascular safety pharmacology studies in dogs enabled for a poorly soluble molecule using spray-dried dispersion: Impact on lead selection Open
The aim of this study was to identify an adequate formulation for a poorly soluble lead molecule (BI-A) that would achieve sufficiently high plasma concentrations after oral administration in dogs to enable a robust cardiovascular safety p…