Marie E. McDonnell
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View article: SAT-526 Trends In Diabetes Medications After Metformin In High Versus Moderate Cardiovascular Risk Patients
SAT-526 Trends In Diabetes Medications After Metformin In High Versus Moderate Cardiovascular Risk Patients Open
Disclosure: M. Lansang: Abbott Laboratories, Dexcom, Neuro Solutions 100. L.C. Petito: None. E. Hegermiller: None. C. Indhumathy: None. R. Carnahan: None. M.E. McDonnell: Dexcom. G. Sylwestrzak: None. A. DeVries: None. E. Priest: AstraZene…
View article: SUN-591 GLP1-RA, SGLT2i and Risk of Advanced Fibrosis in Patients with T2D:a Target Trial Emulation
SUN-591 GLP1-RA, SGLT2i and Risk of Advanced Fibrosis in Patients with T2D:a Target Trial Emulation Open
Disclosure: A. Turchin: Eli Lilly & Company, Research support, Novo Nordisk, Consulting. L. Petito: None. E. Hegermiller: None. R. Carnahan: None. A. DeVries: None. S. Goel: None. M. Lansang: Abbott Laboratories, Research support, Dexcom, …
View article: Cardiovascular Events in Individuals Treated With Sulfonylureas or Dipeptidyl Peptidase 4 Inhibitors
Cardiovascular Events in Individuals Treated With Sulfonylureas or Dipeptidyl Peptidase 4 Inhibitors Open
Importance Sulfonylureas are commonly used to treat type 2 diabetes (T2D). Research findings on cardiovascular risk associated with sulfonylureas have been inconsistent. Objective To emulate a target trial that compares the risk of cardiov…
View article: The renin‐angiotensin‐aldosterone system and salt sensitivity of blood pressure offer new insights in obesity phenotypes
The renin‐angiotensin‐aldosterone system and salt sensitivity of blood pressure offer new insights in obesity phenotypes Open
Objective Individuals who have metabolically healthy overweight/obesity (MHOO) do not have cardiometabolic complications despite an elevated BMI. Renin‐angiotensin‐aldosterone system (RAAS) activation and salt sensitivity of blood pressure…
View article: Addressing Inequity in Continuous Glucose Monitoring Access: Leveraging the Hospital in the Continuum of Care
Addressing Inequity in Continuous Glucose Monitoring Access: Leveraging the Hospital in the Continuum of Care Open
Background: While continuous glucose monitoring (CGM) has transformed the care of people with diabetes (PWD) in the ambulatory setting, there continue to be significant barriers to access. With CGM on the horizon in the acute care setting,…
View article: 9255 Use of Race and Ethnicity in Endocrine Clinical Practice Guidelines
9255 Use of Race and Ethnicity in Endocrine Clinical Practice Guidelines Open
Disclosure: D. Segura Torres: None. K. Raygoza: None. M. Garcia: None. J.P. Brito: None. M.E. McDonnell: None. M. Corrigan: None. C.R. McCartney: None. R. Dhaliwal: None. N.M. Singh Ospina: None. Clinical practice guidelines (CPG) improve …
View article: Insulin resistance during androgen deprivation therapy in men with prostate cancer
Insulin resistance during androgen deprivation therapy in men with prostate cancer Open
Background Androgen deprivation therapy (ADT) in prostate cancer (PCa) has been associated with development of insulin resistance. However, the predominant site of insulin resistance remains unclear. Methods The ADT & Metabolism Study was …
View article: Vitamin D Insufficiency and Epistemic Humility: An Endocrine Society Guideline Communication
Vitamin D Insufficiency and Epistemic Humility: An Endocrine Society Guideline Communication Open
A long-held precept is that vitamin D supplementation primarily, if not exclusively, benefits individuals with low circulating 25-hydroxyvitamin D (25[OH]D) concentrations at baseline. However, the most appropriate 25(OH)D threshold to dis…
View article: Navigating Complexities: Vitamin D, Skin Pigmentation, and Race
Navigating Complexities: Vitamin D, Skin Pigmentation, and Race Open
Vitamin D plays a critical role in many physiological functions, including calcium metabolism and musculoskeletal health. This commentary aims to explore the intricate relationships among skin complexion, race, and 25-hydroxyvitamin D (25[…
View article: Predictors of readmission and mortality in adults with diabetes or stress hyperglycemia after initial hospitalization for COVID-19
Predictors of readmission and mortality in adults with diabetes or stress hyperglycemia after initial hospitalization for COVID-19 Open
Introduction We previously reported predictors of mortality in 1786 adults with diabetes or stress hyperglycemia (glucose>180 mg/dL twice in 24 hours) admitted with COVID-19 from March 2020 to February 2021 to five university hospitals. He…
View article: Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans
Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans Open
Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels and suppress appetite. Here we report a significant elevation of the appetite-suppressing metabolite N -lactoyl phenylalanine …
View article: The impact of using reinforcement learning to personalize communication on medication adherence: findings from the REINFORCE trial
The impact of using reinforcement learning to personalize communication on medication adherence: findings from the REINFORCE trial Open
Text messaging can promote healthy behaviors, like adherence to medication, yet its effectiveness remains modest, in part because message content is rarely personalized. Reinforcement learning has been used in consumer technology to person…
View article: Effect of Testosterone on Progression From Prediabetes to Diabetes in Men With Hypogonadism
Effect of Testosterone on Progression From Prediabetes to Diabetes in Men With Hypogonadism Open
Importance The effect of testosterone replacement therapy (TRT) in men with hypogonadism on the risk of progression from prediabetes to diabetes or of inducing glycemic remission in those with diabetes is unknown. Objective To evaluate the…
View article: 16 Improving diabetes care from a population perspective: maximizing resources and outcomes
16 Improving diabetes care from a population perspective: maximizing resources and outcomes Open
Background Diabetes is a major driver of healthcare cost and utilization in the United States, with one fourth of U.S. health care costs spent on caring for people living with diabetes and approximately 11% of American adults having diabet…
View article: FRI610 Phosphatidylinositol 3-kinase Inhibition With Alpelisib Is Safe And Effective In Treating Refractory Hypoglycemia Associated With Malignant Insulinoma
FRI610 Phosphatidylinositol 3-kinase Inhibition With Alpelisib Is Safe And Effective In Treating Refractory Hypoglycemia Associated With Malignant Insulinoma Open
Disclosure: Y. Kang: None. D.A. Rubinson: None. I. Odintsov: None. A. Vaidya: None. J.S. Williams: None. G.K. Adler: None. M.E. McDonnell: None. M. Patti: Advisory Board Member; Self; Fractyl Laboratories. Consulting Fee; Self; AstraZeneca…
View article: Diabetes Mellitus Type 1 Presenting in the Setting of Diabetic Ketoacidosis and Acute SARS-CoV-2 Infection in Pregnancy
Diabetes Mellitus Type 1 Presenting in the Setting of Diabetic Ketoacidosis and Acute SARS-CoV-2 Infection in Pregnancy Open
Prompt diagnosis and evaluation of DKA in pregnancy as well as a higher level of suspicion is needed in the setting of SARS-CoV-2 infection. Additionally, this case depicts the need for closely monitoring the postpartum period for patients…
View article: Gaining metabolic insight in older men undergoing androgen deprivation therapy for prostate cancer (the ADT & Metabolism Study): Protocol of a longitudinal, observational, cohort study
Gaining metabolic insight in older men undergoing androgen deprivation therapy for prostate cancer (the ADT & Metabolism Study): Protocol of a longitudinal, observational, cohort study Open
Androgen deprivation therapy (ADT), a cornerstone of treatment for patients with locally advanced and metastatic prostate cancer, is associated with many adverse effects, including osteoporosis, sexual dysfunction, fatigue, and vasomotor s…
View article: RF28 | PSUN185 The effects of diabetes and glycemic control on cancer outcomes in individuals with metastatic breast cancer
RF28 | PSUN185 The effects of diabetes and glycemic control on cancer outcomes in individuals with metastatic breast cancer Open
Background While a well-established relationship between diabetes and breast cancer exists, it remains unclear how diabetes impacts breast cancer outcomes. This study aims to determine the impact/association of diabetes and hyperglycemia o…
View article: Glycemic Gap Predicts Mortality in a Large Multicenter Cohort Hospitalized With COVID-19
Glycemic Gap Predicts Mortality in a Large Multicenter Cohort Hospitalized With COVID-19 Open
Context Diabetes or hyperglycemia at admission are established risk factors for adverse outcomes during hospitalization for COVID-19, but the impact of prior glycemic control is not clear. Objective We aimed to examine the associations bet…
View article: Appropriate Use of Telehealth Visits in Endocrinology: Policy Perspective of the Endocrine Society
Appropriate Use of Telehealth Visits in Endocrinology: Policy Perspective of the Endocrine Society Open
Objective This work aims to guide clinicians practicing endocrinology in the use of telehealth (synchronous patient-clinician visits conducted over video or telephone) for outpatient care. Participants The Endocrine Society convened a 9-me…
View article: Response to Letter to the Editor From Banerjee and Mondal: “Management of Hyperglycemia in Hospitalized Adult Patients in Noncritical Care Settings: An Endocrine Society Clinical Practice Guideline”
Response to Letter to the Editor From Banerjee and Mondal: “Management of Hyperglycemia in Hospitalized Adult Patients in Noncritical Care Settings: An Endocrine Society Clinical Practice Guideline” Open
concerns including cost-effectiveness (1).Overall, given the available published science, we found that, on balance, potential harms outweighed potential benefits of using these medications for glycemic control during hospitalization.
View article: Report of Prolonged Neonatal Hypoglycemia in Three Infants of Mothers With Variants in HNF1A
Report of Prolonged Neonatal Hypoglycemia in Three Infants of Mothers With Variants in HNF1A Open
Although confounding factors make the assessment of neonatal hypoglycemia challenging, these cases offer potential support for single genetic variants in HNF1A causing both MODY and neonatal hypoglycemia, with associated fetal overgrowth i…
View article: The Effects of Diabetes and Glycemic Control on Cancer Outcomes in Individuals With Metastatic Breast Cancer
The Effects of Diabetes and Glycemic Control on Cancer Outcomes in Individuals With Metastatic Breast Cancer Open
Background It is unclear whether diabetes and glycemic control affects the outcomes of breast cancer, especially among those with metastatic disease. This study aims to determine the impact of diabetes and hyperglycemia on cancer progressi…
View article: Enhancing the Trustworthiness of the Endocrine Society’s Clinical Practice Guidelines
Enhancing the Trustworthiness of the Endocrine Society’s Clinical Practice Guidelines Open
In an effort to enhance the trustworthiness of its clinical practice guidelines, the Endocrine Society has recently adopted new policies and more rigorous methodologies for its guideline program. In this Clinical Practice Guideline Communi…
View article: Management of Hyperglycemia in Hospitalized Adult Patients in Non-Critical Care Settings: An Endocrine Society Clinical Practice Guideline
Management of Hyperglycemia in Hospitalized Adult Patients in Non-Critical Care Settings: An Endocrine Society Clinical Practice Guideline Open
Background Adult patients with diabetes or newly recognized hyperglycemia account for over 30% of noncritically ill hospitalized patients. These patients are at increased risk for adverse clinical outcomes in the absence of defined approac…
View article: Development and Usability of a Text Messaging Program for Women With Gestational Diabetes: Mixed Methods Study
Development and Usability of a Text Messaging Program for Women With Gestational Diabetes: Mixed Methods Study Open
Background Gestational diabetes mellitus (GDM) affects 5%-10% of pregnancies and can lead to serious fetal and maternal complications. SMS text messaging is an effective way to improve diabetes management outside of pregnancy, but has not …
View article: REinforcement learning to improve non-adherence for diabetes treatments by Optimising Response and Customising Engagement (REINFORCE): study protocol of a pragmatic randomised trial
REinforcement learning to improve non-adherence for diabetes treatments by Optimising Response and Customising Engagement (REINFORCE): study protocol of a pragmatic randomised trial Open
Introduction Achieving optimal diabetes control requires several daily self-management behaviours, especially adherence to medication. Evidence supports the use of text messages to support adherence, but there remains much opportunity to i…
View article: Exploring patient experiences coping with using multiple medications: a qualitative interview study
Exploring patient experiences coping with using multiple medications: a qualitative interview study Open
Objective Long-term adherence to evidence-based medications in cardiometabolic diseases remains poor, despite extensive efforts to develop and test interventions and deploy clinician performance incentives. The limited success of intervent…
View article: Development and Usability of a Text Messaging Program for Women With Gestational Diabetes: Mixed Methods Study (Preprint)
Development and Usability of a Text Messaging Program for Women With Gestational Diabetes: Mixed Methods Study (Preprint) Open
BACKGROUND Gestational diabetes mellitus (GDM) affects 5%-10% of pregnancies and can lead to serious fetal and maternal complications. SMS text messaging is an effective way to improve diabetes management outside of pregnancy, but has not…