Michael S. McGrath
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View article: Oral Microbiome and Inferred Functions Predict Kaposi's Sarcoma Progression
Oral Microbiome and Inferred Functions Predict Kaposi's Sarcoma Progression Open
Kaposi′s sarcoma (KS) is a common cancer among people living with HIV and is caused by infection with Kaposi′s sarcoma‐associated herpesvirus (KSHV). While previous studies have linked the oral microbiome to KSHV infection and KS developme…
View article: Spatial Single-Cell Atlas Reveals KSHV-Driven Broad Cellular Reprogramming, Progenitor Expansion, Immune and Vascular Remodeling in Kaposi’s Sarcoma
Spatial Single-Cell Atlas Reveals KSHV-Driven Broad Cellular Reprogramming, Progenitor Expansion, Immune and Vascular Remodeling in Kaposi’s Sarcoma Open
Summary Kaposi’s sarcoma (KS) is a highly inflammatory, angiogenic tumor driven by Kaposi’s sarcoma-associated herpesvirus (KSHV), yet the origins of tumor cells and mechanisms of progression remain unclear. Here, we present the first spat…
View article: Do fluctuations in oestradiol and progesterone across the menstrual cycle affect mechanical stiffness in female athletes?
Do fluctuations in oestradiol and progesterone across the menstrual cycle affect mechanical stiffness in female athletes? Open
Female rugby league players have significantly higher ankle joint, knee joint and leg mechanical stiffness when oestradiol was highest, typically during Phase-2 of the menstrual cycle. It is possible that dynamic stiffness of the lower lim…
View article: Respiratory Function Improvement and Lifespan Extension Following Immunotherapy with NP001 Support the Concept That Amyotrophic Lateral Sclerosis (ALS) Is an Immuno-Neurologic Disease
Respiratory Function Improvement and Lifespan Extension Following Immunotherapy with NP001 Support the Concept That Amyotrophic Lateral Sclerosis (ALS) Is an Immuno-Neurologic Disease Open
Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease that involves progressive loss of voluntary muscle and ultimately, respiratory function, which is the primary cause of death in ALS patients. Respiratory vital capacity (VC) me…
View article: Systemic Innate Immune System Restoration as a Therapeutic Approach for Neurodegenerative Disease: Effects of NP001 on Amyotrophic Lateral Sclerosis (ALS) Progression
Systemic Innate Immune System Restoration as a Therapeutic Approach for Neurodegenerative Disease: Effects of NP001 on Amyotrophic Lateral Sclerosis (ALS) Progression Open
Background/objective: Amyotrophic lateral sclerosis (ALS) is a diagnosis that incorporates a heterogeneous set of neurodegenerative processes into a single progressive and uniformly fatal disease making the development of a uniformly appli…
View article: The Effectiveness of NP001 on the Long-Term Survival of Patients with Amyotrophic Lateral Sclerosis
The Effectiveness of NP001 on the Long-Term Survival of Patients with Amyotrophic Lateral Sclerosis Open
Background/Objectives: The aim of this study was to estimate the effect of a 6 months’ treatment course of the innate immune modulator NP001 (a pH-adjusted intravenous formulation of purified sodium chlorite), on disease progression, as me…
View article: Protocol for the simultaneous isolation of DNA, RNA, and miRNA from a single archived Kaposi sarcoma biopsy
Protocol for the simultaneous isolation of DNA, RNA, and miRNA from a single archived Kaposi sarcoma biopsy Open
Kaposi sarcoma (KS) punch biopsies present unique challenges for extracting nucleic acids, which can be exacerbated by their long-term stabilization in RNAlater. Here, we present a protocol for simultaneously isolating DNA, RNA, and miRNA …
View article: Utility of an Archival Dried Blood Spot (DBS) Collection from HIV-Infected Individuals with and without Cancer in a Resource-Limited Setting
Utility of an Archival Dried Blood Spot (DBS) Collection from HIV-Infected Individuals with and without Cancer in a Resource-Limited Setting Open
The frequency of virus-associated cancers is growing worldwide, especially in resource-limited settings. One of the biggest challenges in cancer research among people living with HIV (PLWH) has been understanding how infection with both HI…
View article: Abstract No. 60 Genetic Analysis of Vascular Malformations
Abstract No. 60 Genetic Analysis of Vascular Malformations Open
View article: The Effectiveness of NP001 on Long Term Survival of Patients with Amyotrophic Lateral Sclerosis: The IKARIA Study
The Effectiveness of NP001 on Long Term Survival of Patients with Amyotrophic Lateral Sclerosis: The IKARIA Study Open
View article: HIV-1 subtypes maintain distinctive physicochemical signatures in Nef domains associated with immunoregulation
HIV-1 subtypes maintain distinctive physicochemical signatures in Nef domains associated with immunoregulation Open
Recent studies have focused on HIV Nef as a driver of immunoregulatory disease in those HIV infected and on ART. Nef acts through a complex mixture of interactions that are directly linked to the key features of the subtype-specific domain…
View article: Regulation of the Innate Immune System as a Therapeutic Approach to Supporting Respiratory Function in ALS
Regulation of the Innate Immune System as a Therapeutic Approach to Supporting Respiratory Function in ALS Open
Amyotrophic lateral sclerosis (ALS) is a clinical diagnosis used to define a neurodegenerative process that involves progressive loss of voluntary muscle function and leads to death within 2–5 years after diagnosis, in most cases because o…
View article: The Persistence of HIV Diversity, Transcription, and Nef Protein in Kaposi’s Sarcoma Tumors during Antiretroviral Therapy
The Persistence of HIV Diversity, Transcription, and Nef Protein in Kaposi’s Sarcoma Tumors during Antiretroviral Therapy Open
Epidemic Kaposi’s sarcoma (KS), defined by co-infection with Human Herpes Virus 8 (HHV-8) and the Human Immunodeficiency Virus (HIV), is a major cause of mortality in sub-Saharan Africa. Antiretroviral therapy (ART) significantly reduces t…
View article: PP 1.26 – 00143 Understanding HIV transcription in Kaposi's sarcoma tumors during antiretroviral therapy
PP 1.26 – 00143 Understanding HIV transcription in Kaposi's sarcoma tumors during antiretroviral therapy Open
View article: Macrophage-Targeted Sodium Chlorite (NP001) Slows Progression of Amyotrophic Lateral Sclerosis (ALS) through Regulation of Microbial Translocation
Macrophage-Targeted Sodium Chlorite (NP001) Slows Progression of Amyotrophic Lateral Sclerosis (ALS) through Regulation of Microbial Translocation Open
Amyotrophic lateral sclerosis (ALS) is a heterogeneous, progressive, and universally fatal neurodegenerative disease. A subset of ALS patients has measurable plasma levels of lipopolysaccharide (LPS) and C-reactive protein (CRP) consistent…
View article: Phase <scp>2B</scp> randomized controlled trial of <scp>NP001</scp> in amyotrophic lateral sclerosis: Pre‐specified and post hoc analyses
Phase <span>2B</span> randomized controlled trial of <span>NP001</span> in amyotrophic lateral sclerosis: Pre‐specified and post hoc analyses Open
Introduction/Aims ALS is a heterogeneous disease that may be complicated or in part driven by inflammation. NP001, a regulator of macrophage activation, was associated with slowing disease progression in those with higher levels of the pla…
View article: Assessment of 2-Year Storage Conditions on Protein, RNA, and DNA in Unstained Human Tissue Sections, Including a Novel Multiplex Digital Gene Expression Profiling Method with Implications for Biobanking
Assessment of 2-Year Storage Conditions on Protein, RNA, and DNA in Unstained Human Tissue Sections, Including a Novel Multiplex Digital Gene Expression Profiling Method with Implications for Biobanking Open
Background: Formalin-fixed, paraffin-embedded (FFPE) tissues are a valuable resource for clinical and basic science research. Paraffin blocks and the resulting unstained sections (USS) are often stored for years before being …
View article: The Role of Bacteria in KSHV Infection and KSHV-Induced Cancers
The Role of Bacteria in KSHV Infection and KSHV-Induced Cancers Open
The objective of this article is to review the current status of the bacteria-virus interplay in Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-driven cancers. KSHV is the etiological agent of several cancers, including …
View article: Pseudomonas aeruginosa Stimulates Inflammation and Enhances Kaposi’s Sarcoma Herpesvirus-Induced Cell Proliferation and Cellular Transformation through both Lipopolysaccharide and Flagellin
Pseudomonas aeruginosa Stimulates Inflammation and Enhances Kaposi’s Sarcoma Herpesvirus-Induced Cell Proliferation and Cellular Transformation through both Lipopolysaccharide and Flagellin Open
Kaposi’s sarcoma (KS), caused by infection with Kaposi’s sarcoma-associated herpesvirus (KSHV), is one of the most common cancers in AIDS patients. KS is a highly inflammatory tumor, but how KSHV infection induces inflammation remains uncl…
View article: <i>Pseudomonas aeruginosa</i>Stimulates Inflammation and Enhances KSHV-Induced Cell Proliferation and Cellular Transformation through Both LPS and Flagellin
<i>Pseudomonas aeruginosa</i>Stimulates Inflammation and Enhances KSHV-Induced Cell Proliferation and Cellular Transformation through Both LPS and Flagellin Open
Inflammation triggered by innate immunity promotes carcinogenesis in cancer. Kaposi’s sarcoma (KS), a hyperproliferative and inflammatory tumor caused by Kaposi’s sarcoma-associated herpesvirus (KSHV) infection, is the most common cancer i…
View article: Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency
Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency Open
Objective: To investigate associations between peripheral innate immune activation and frontotemporal lobar degeneration (FTLD) in progranulin gene (GRN) haploinsufficiency. Methods: In this cross-sectional study, ELIS…
View article: Enhanced DNA repair and genomic stability identify a novel HIV‐related diffuse large B‐cell lymphoma signature
Enhanced DNA repair and genomic stability identify a novel HIV‐related diffuse large B‐cell lymphoma signature Open
Diffuse large B‐cell lymphoma (DLBCL) is up to 17‐fold more likely to occur, follows a more aggressive clinical course and frequently presents at advanced stages in HIV infected (+) individuals compared to HIV negative (−) individuals. How…
View article: Emerging Patterns in HIV-1 gp120 Variable Domains in Anatomical Tissues in the Absence of a Plasma Viral Load
Emerging Patterns in HIV-1 gp120 Variable Domains in Anatomical Tissues in the Absence of a Plasma Viral Load Open
The HIV envelope protein contains five hypervariable domains (V1-V5) that are fundamental for cell entry. We contrasted modifications in the variable domains derived from a panel of 24 tissues from 7 subjects with no measurable plasma vira…
View article: Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes
Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes Open
Monocyte activation and polarization play essential roles in many chronic inflammatory diseases. An imbalance of M1 and M2 macrophage activation (pro-inflammatory and alternatively activated, respectively) is believed to be a key aspect in…
View article: AIDS and Cancer Specimen Resource (ACSR)
AIDS and Cancer Specimen Resource (ACSR) Open
The AIDS and Cancer Specimen Resource (ACSR) has four regional biorepositories (RBRs) in the United States and one in South Africa. The ACSR is funded by the National Cancer Institute (NCI) of the National Institutes of Health (United Stat…
View article: Disease-specific HIV Nef identified in multiple patients with neurological disorders and cancers
Disease-specific HIV Nef identified in multiple patients with neurological disorders and cancers Open
View article: The Spleen Is an HIV-1 Sanctuary During Combined Antiretroviral Therapy
The Spleen Is an HIV-1 Sanctuary During Combined Antiretroviral Therapy Open
Combined antiretroviral therapy (cART) does not eradicate HIV, which persists for years and can re-establish replication if treatment is stopped. The current challenge is identifying those tissues harboring virus through cART. Here, we use…
View article: Brain-specific HIV Nef identified in multiple patients with neurological disease
Brain-specific HIV Nef identified in multiple patients with neurological disease Open
View article: Eradication of HIV from Tissue Reservoirs: Challenges for the Cure
Eradication of HIV from Tissue Reservoirs: Challenges for the Cure Open
The persistence of HIV infection, even after lengthy and successful combined antiretroviral therapy (cART), has precluded an effective cure. The anatomical locations and biological mechanisms through which the viral population is maintaine…
View article: An oral form of methylglyoxal-bis-guanylhydrazone reduces monocyte activation and traffic to the dorsal root ganglia in a primate model of HIV-peripheral neuropathy
An oral form of methylglyoxal-bis-guanylhydrazone reduces monocyte activation and traffic to the dorsal root ganglia in a primate model of HIV-peripheral neuropathy Open