Michael J. McKenna
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View article: Exercise attenuates stress-related signaling as sensed by higher phosphorylation of small heat shock proteins in skeletal muscle from older individuals
Exercise attenuates stress-related signaling as sensed by higher phosphorylation of small heat shock proteins in skeletal muscle from older individuals Open
HIT has the potential to mitigate age-related cellular stress and modulate protein expression patterns in aging skeletal muscle and, perhaps, has the potential to delay age-related muscle decline, thereby improving muscle health in older a…
View article: Exploring the impact of waiting time on physical function and psychosocial measures in individuals with lower limb osteoarthritis awaiting orthopaedic consultation
Exploring the impact of waiting time on physical function and psychosocial measures in individuals with lower limb osteoarthritis awaiting orthopaedic consultation Open
Osteoarthritis (OA) is a muscular condition that often requires treatment by orthopaedic specialists leading to length waiting periods. The study aim was to examine associations between waiting time, physical function and psychosocial vari…
View article: Effects of mindfulness training on sustained attention and mind-wandering in older adults: A randomized controlled trial
Effects of mindfulness training on sustained attention and mind-wandering in older adults: A randomized controlled trial Open
Older adults exhibit age-related declines in processes of attentional control,demonstrating an emergent need to identify mind-body interventions that support healthycognitive aging. Mindfulness training is a promising intervention for impr…
View article: Exercise- and diet-induced glycogen depletion impairs performance during one-legged constant-load, high-intensity exercise in humans
Exercise- and diet-induced glycogen depletion impairs performance during one-legged constant-load, high-intensity exercise in humans Open
Introduction The effect of muscle glycogen stores on performance during intense short-duration exercises in humans is unclear. We hypothesized that low initial muscle glycogen levels would impair constant-load intense one-legged knee exten…
View article: Hypertension and blood pressure changes with dolutegravir or comparator antiretroviral therapy in randomized trials through 96 weeks
Hypertension and blood pressure changes with dolutegravir or comparator antiretroviral therapy in randomized trials through 96 weeks Open
Background To date, there are limited published data from randomized trials evaluating the effects of integrase strand transfer inhibitor-based regimens, including dolutegravir-based antiretroviral therapy (ART), on blood pressure (BP) in …
View article: Physiological Responses to High‐Intensity Interval Exercise in Hypoxia Among Lean Males and Those With Overweight or Obesity
Physiological Responses to High‐Intensity Interval Exercise in Hypoxia Among Lean Males and Those With Overweight or Obesity Open
This study aimed to compare physiological responses to high‐intensity interval exercise (HIIE) in hypoxia and normoxia across different body mass index (BMI) categories. Twenty‐one males, classified as normal‐weight (NW, n = 9 and BMI: 22.…
View article: Prediction of future aging-related slow gait and its determinants with deep learning and logistic regression
Prediction of future aging-related slow gait and its determinants with deep learning and logistic regression Open
Background Identification of accelerated aging and its biomarkers can lead to more timely therapeutic interventions and decision-making. Therefore, we sought to predict aging-related slow gait, a known predictor of accelerated aging, and i…
View article: Effects of mindfulness training on sustained attention and mind-wandering in older adults: A randomized controlled trial
Effects of mindfulness training on sustained attention and mind-wandering in older adults: A randomized controlled trial Open
Older adults exhibit age-related declines in processes of attentional control,demonstrating an emergent need to identify mind-body interventions that support healthycognitive aging. Mindfulness training is a promising intervention for impr…
View article: Efficacy and Safety of the Two-Drug Regimen Dolutegravir–Lamivudine in Adolescents Living With HIV-1 Naive to Antiretroviral Therapy at 48 Weeks (DANCE): A Single-Arm, Open-Label, Phase 3b Trial
Efficacy and Safety of the Two-Drug Regimen Dolutegravir–Lamivudine in Adolescents Living With HIV-1 Naive to Antiretroviral Therapy at 48 Weeks (DANCE): A Single-Arm, Open-Label, Phase 3b Trial Open
Background: Dolutegravir–lamivudine is recommended for initial antiretroviral therapy (ART) in adults living with HIV-1; however, no clinical trials have assessed this regimen in adolescents, a potentially more challenging population to tr…
View article: A Model‐Based Approach Supporting Abacavir/Dolutegravir/Lamivudine Fixed‐Dose Combination Approval in Children Living with HIV‐1
A Model‐Based Approach Supporting Abacavir/Dolutegravir/Lamivudine Fixed‐Dose Combination Approval in Children Living with HIV‐1 Open
In March 2022, the US Food and Drug Administration expanded indications of TRIUMEQ, a once‐daily fixed‐dose combination (FDC) containing abacavir (ABC), dolutegravir (DTG), and lamivudine (3TC) to include pediatric patients weighing at lea…
View article: Digoxin and exercise effects on skeletal muscle Na<sup>+</sup>,K<sup>+</sup>‐ATPase isoform gene expression in healthy humans
Digoxin and exercise effects on skeletal muscle Na<sup>+</sup>,K<sup>+</sup>‐ATPase isoform gene expression in healthy humans Open
In muscle, digoxin inhibits Na + ,K + ‐ATPase (NKA) whereas acute exercise can increase NKA gene expression, consistent with training‐induced increased NKA content. We investigated whether oral digoxin increased NKA isoform mRNA expression…
View article: Physical activity and depression symptoms in people with osteoarthritis-related pain: A cross-sectional study
Physical activity and depression symptoms in people with osteoarthritis-related pain: A cross-sectional study Open
Osteoarthritis is a leading cause of chronic pain and is associated with high rates of depression. Physical activity reduces depression symptoms and pain levels. It remains unknown if physical activity is associated with lower symptoms of …
View article: Differential effects of contracting muscle mass and relative exercise intensity on arterial plasma potassium concentration during and following incremental arm and leg cycling exercise
Differential effects of contracting muscle mass and relative exercise intensity on arterial plasma potassium concentration during and following incremental arm and leg cycling exercise Open
Whilst arm cycling is commonly used during clinical testing and rehabilitation, the associated changes in arterial plasma K+ concentration ([K+]a) and thus possible risks of associated hyperkalaemia and hypokalaemia are unknown. During exe…
View article: An Eigenfunction Approach to Conversion of the Laplace Transform of Point Masses on the Real Line to the Fourier Domain
An Eigenfunction Approach to Conversion of the Laplace Transform of Point Masses on the Real Line to the Fourier Domain Open
Motivated by applications in magnetic resonance relaxometry, we consider the following problem: Given samples of a function $t\mapsto \sum_{k=1}^K A_k\exp(-tλ_k)$, where $K\ge 2$ is an integer, $A_k\in\mathbb{R}$, $λ_k>0$ for $k=1,\cdots, …
View article: A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration—historical developments
A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration—historical developments Open
This historical review traces key discoveries regarding K + and Na + ions in skeletal muscle at rest and with exercise, including contents and concentrations, Na + ,K + -ATPase (NKA) and exercise effects on plasma [K + ] in humans. Followi…
View article: Development of a Digital Health Intervention to Support Patients on a Waitlist for Orthopedic Specialist Care: Co-Design Study
Development of a Digital Health Intervention to Support Patients on a Waitlist for Orthopedic Specialist Care: Co-Design Study Open
Background The demand for orthopedic specialist consultations for patients with osteoarthritis in public hospitals is high and continues to grow. Lengthy waiting times are increasingly affecting patients from low socioeconomic and cultural…
View article: Issue Information
Issue Information Open
The Americas), $179 (Rest of World).Prices are exclusive of tax.Asia-Pacific
View article: Effect of Food on the Pediatric Dispersible Tablet Formulations of TRIUMEQ and DOVATO in Healthy Adult Participants
Effect of Food on the Pediatric Dispersible Tablet Formulations of TRIUMEQ and DOVATO in Healthy Adult Participants Open
This randomized food effect study in healthy adult participants examined dispersible tablet formulations of fixed-dose combinations of dolutegravir/abacavir/lamivudine (TRIUMEQ) and dolutegravir/lamivudine (DOVATO). While adult tablet form…
View article: Development of a Digital Health Intervention to Support Patients on a Waitlist for Orthopedic Specialist Care: Co-Design Study (Preprint)
Development of a Digital Health Intervention to Support Patients on a Waitlist for Orthopedic Specialist Care: Co-Design Study (Preprint) Open
BACKGROUND The demand for orthopedic specialist consultations for patients with osteoarthritis in public hospitals is high and continues to grow. Lengthy waiting times are increasingly affecting patients from low socioeconomic and cultura…
View article: Oral digoxin effects on exercise performance, K<sup>+</sup> regulation and skeletal muscle Na<sup>+</sup>,K<sup>+</sup>‐ATPase in healthy humans
Oral digoxin effects on exercise performance, K<sup>+</sup> regulation and skeletal muscle Na<sup>+</sup>,K<sup>+</sup>‐ATPase in healthy humans Open
We investigated whether digoxin lowered muscle Na + ,K + ‐ATPase (NKA), impaired muscle performance and exacerbated exercise K + disturbances. Ten healthy adults ingested digoxin (0.25 mg; DIG) or placebo (CON) for 14 days and performed qu…
View article: The four-fifths rule is not disparate impact: a woeful tale of epistemic trespassing in algorithmic fairness
The four-fifths rule is not disparate impact: a woeful tale of epistemic trespassing in algorithmic fairness Open
Computer scientists are trained to create abstractions that simplify and generalize. However, a premature abstraction that omits crucial contextual details creates the risk of epistemic trespassing, by falsely asserting its relevance into …
View article: Guidelines for composing and assessing a paper on the treatment of pain: A practical application of evidence-based medicine principles to a cost-effectiveness analysis of the MINT randomized clinical trials
Guidelines for composing and assessing a paper on the treatment of pain: A practical application of evidence-based medicine principles to a cost-effectiveness analysis of the MINT randomized clinical trials Open
The cost analysis performed in "Cost-Effectiveness of Radiofrequency Denervation for Patients With Chronic Low Back Pain: The MINT Randomized Clinical Trials" is based on the MINT RCTs results. The MINT RCTs significant metholodological de…
View article: A single oral glucose load decreases arterial plasma [K <sup>+</sup> ] during exercise and recovery
A single oral glucose load decreases arterial plasma [K <sup>+</sup> ] during exercise and recovery Open
Acute oral glucose ingestion, as used in a glucose tolerance test, induced a small, systemic K+ -lowering effect before, during, and after HIIC, that was detectable in both arterial and venous plasma. This likely reflects insulin-mediated,…