Michael McMahon
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View article: Pancreatic, nutritional and clinical outcomes in children 0–5 years with cystic fibrosis during the first 2 years of CFTR modulator therapy (PaNC): a multicentre prospective observational study protocol
Pancreatic, nutritional and clinical outcomes in children 0–5 years with cystic fibrosis during the first 2 years of CFTR modulator therapy (PaNC): a multicentre prospective observational study protocol Open
Background Cystic fibrosis (CF) is a genetic condition of impaired membrane electrolyte transport and is characterised by defects in the production and function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Gro…
View article: DOES THE BANK OF ENGLAND NEED GENDERED COMMUNICATION?
DOES THE BANK OF ENGLAND NEED GENDERED COMMUNICATION? Open
This study examines gender differences in inflation expectations, attitudes and responses using the UK Inflation Attitudes Survey. It finds minimal gender disparity in inflation perceptions and expectations but highlights greater uncertain…
View article: Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies
Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies Open
Chemical risk assessment ensures protection from the toxic effects of drugs and manmade chemicals. To comply with regulatory guidance, studies in complex organisms are required, as well as mechanistic studies to establish the relevance of …
View article: Diversities of Design: Celebrating Plurality in the Anthropocene
Diversities of Design: Celebrating Plurality in the Anthropocene Open
Within an Australian context, the realisation of decarbonised and de-colonial futures requires scrutiny of the socio-political industrial complex upon which the contemporary Australian settler-colonial project was founded. Central to this …
View article: Clinicoradiological outcomes after radical radiotherapy for lung cancer in patients with interstitial lung disease
Clinicoradiological outcomes after radical radiotherapy for lung cancer in patients with interstitial lung disease Open
Objective: Interstitial lung disease (ILD) is relatively common in patients with lung cancer with an incidence of 7.5%. Historically pre-existing ILD was a contraindication to radical radiotherapy owing to increased radiation pneumonitis r…
View article: Supplementary Figures 6-7 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figures 6-7 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S6: Beta-gal staining of uterus sections from untreated and irradiated p21 reporter mice. Figure S7: Beta-gal staining of whole lung, large intestine and liver sections from untreated and irradiated p21 reporter mice.
View article: Supplementary Figures 4-5 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figures 4-5 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S4: Beta-gal staining of lung, liver, and kidney sections from untreated and irradiated p21 reporter mice. Figure S5: Beta-gal staining of spleen, thymus, and heart sections from untreated and irradiated p21 reporter mice.
View article: Supplementary Figures 4-5 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figures 4-5 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S4: Beta-gal staining of lung, liver, and kidney sections from untreated and irradiated p21 reporter mice. Figure S5: Beta-gal staining of spleen, thymus, and heart sections from untreated and irradiated p21 reporter mice.
View article: Supplementary Figures 11-13 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figures 11-13 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S11: Bioluminescence from irradiated reporter mice. Figure S12: Visceral organ bioluminescence observed by invasive imaging. Figure S13: Pharmacokinetic parameters for olaparib in wild-type mice are linearly related to dose.
View article: Supplementary Figure 10 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figure 10 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S10: Beta-gal staining of various organs from control and etoposide-treated p21 reporter mice.
View article: Supplementary Figures 1-3 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figures 1-3 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S1: Quantitative analysis of the immunoblots of Fig 1B. Figure S2: Quantitative analysis of the immunoblots of Fig 1C. Figure S3: Beta-gal staining of brain sections from an untreated p21 reporter mouse.
View article: Supplementary Figures 8-9 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figures 8-9 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S8: Î’-gal staining is localized to the nucleus of cells. Figure S9: Kidney and liver function tests on plasma from cisplatin-treated reporter mice.
View article: Supplementary Figure 10 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figure 10 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S10: Beta-gal staining of various organs from control and etoposide-treated p21 reporter mice.
View article: Supplementary Figures 8-9 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figures 8-9 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S8: Î’-gal staining is localized to the nucleus of cells. Figure S9: Kidney and liver function tests on plasma from cisplatin-treated reporter mice.
View article: Data from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Data from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Many drugs targeting the DNA damage response are being developed as anticancer therapies, either as single agents or in combination with ionizing radiation (IR) or other cytotoxic agents. Numerous clinical trials in this area are either in…
View article: Supplementary Figures 6-7 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figures 6-7 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S6: Beta-gal staining of uterus sections from untreated and irradiated p21 reporter mice. Figure S7: Beta-gal staining of whole lung, large intestine and liver sections from untreated and irradiated p21 reporter mice.
View article: SUPPORTING INFORMATION from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
SUPPORTING INFORMATION from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Contains one Appendix, Supplementary Materials and Methods, Supplementary References, and Supplementary Figure Legends.
View article: Supplementary Figures 1-3 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figures 1-3 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S1: Quantitative analysis of the immunoblots of Fig 1B. Figure S2: Quantitative analysis of the immunoblots of Fig 1C. Figure S3: Beta-gal staining of brain sections from an untreated p21 reporter mouse.
View article: Data from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Data from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Many drugs targeting the DNA damage response are being developed as anticancer therapies, either as single agents or in combination with ionizing radiation (IR) or other cytotoxic agents. Numerous clinical trials in this area are either in…
View article: Supplementary Figures 11-13 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
Supplementary Figures 11-13 from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Figure S11: Bioluminescence from irradiated reporter mice. Figure S12: Visceral organ bioluminescence observed by invasive imaging. Figure S13: Pharmacokinetic parameters for olaparib in wild-type mice are linearly related to dose.
View article: SUPPORTING INFORMATION from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse
SUPPORTING INFORMATION from Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse Open
Contains one Appendix, Supplementary Materials and Methods, Supplementary References, and Supplementary Figure Legends.
View article: Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies
Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies Open
Chemical risk assessment ensures protection from the toxic effects of drugs and manmade chemicals. To comply with regulatory guidance, studies in complex organisms are required, as well as mechanistic studies to establish the relevance of …
View article: A Deployed Soldier Presenting With Dyspnea and Orthopnea Due to a Morgagni Hernia
A Deployed Soldier Presenting With Dyspnea and Orthopnea Due to a Morgagni Hernia Open
Shortness of breath is an important complaint in the austere setting with a broad differential diagnosis. The difficulty of deployed patient movement and lack of diagnostic testing at treatment sites complicates its evaluation. This case h…
View article: JShelter: Give Me My Browser Back
JShelter: Give Me My Browser Back Open
The web is used daily by billions. Even so, users are not protected from many threats by default. This position paper builds on previous web privacy and security research and introduces JShelter, a webextension that fights to return the br…
View article: Motor Cortex EEG (C3, Cz, C4) from both OpenBCI & g.tec Unicorn Naked devices
Motor Cortex EEG (C3, Cz, C4) from both OpenBCI & g.tec Unicorn Naked devices Open
In this experiment we tested if a novel Mobile-EEG Cloud System recording over 4G network based on the OpenBCI board could produce comparable results to an equivalent EEG Local System recording over BLE based on the g.tec Unicorn Naked und…
View article: A mobile EEG (C3, Cz, C4) activity labelled dataset recorded during unconstrained movement in an urban setting
A mobile EEG (C3, Cz, C4) activity labelled dataset recorded during unconstrained movement in an urban setting Open
In this experiment we tested if a novel Mobile-EEG Cloud System based on the OpenBCI board recording over 4G network could generate labelled EEG datasets for subjects in unconstrained urban environments suitable for Machine Learning Traini…
View article: Motor Cortex EEG (C3, Cz, C4) from both OpenBCI & g.tec Unicorn Naked devices
Motor Cortex EEG (C3, Cz, C4) from both OpenBCI & g.tec Unicorn Naked devices Open
In this experiment we tested if a novel Mobile-EEG Cloud System recording over 4G network based on the OpenBCI board could produce comparable results to an equivalent EEG Local System recording over BLE based on the g.tec Unicorn Naked und…