Marc L. Melcher
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View article: Donor-Recipient Age Mismatch and Long-Term Graft Outcomes After Adolescent Liver Transplant
Donor-Recipient Age Mismatch and Long-Term Graft Outcomes After Adolescent Liver Transplant Open
Importance Donor-recipient age mismatch is an established risk factor in adult liver transplants (LTs), yet its effect in adolescents, who require long-term graft durability, has not been fully characterized. Despite pediatric prioritizati…
View article: Defining Gene Signature of Tumor-Associated Macrophages in Intrahepatic Cholangiocarcinoma as Target for Immunotherapy Using Single Cell and Bulk RNA Sequencing
Defining Gene Signature of Tumor-Associated Macrophages in Intrahepatic Cholangiocarcinoma as Target for Immunotherapy Using Single Cell and Bulk RNA Sequencing Open
Background: Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis due to late-stage presentation and ineffective systemic therapies. Targeting the tumor microenvironment (TME) in ICC offers new therapeutic possibilities, particularly …
View article: Development and validation of a machine-learning model to reduce futile procurements in donations after circulatory death in liver transplantation in the USA: a multicentre study
Development and validation of a machine-learning model to reduce futile procurements in donations after circulatory death in liver transplantation in the USA: a multicentre study Open
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View article: Insights From Refusal Patterns for Deceased Donor Kidney Offers
Insights From Refusal Patterns for Deceased Donor Kidney Offers Open
Background. The likelihood that a deceased donor kidney will be used evolves during the allocation process. Transplant centers can either decline an organ offer for a single patient or for multiple patients at the same time. We hypothesize…
View article: Revisiting the Prognostic Influences of Donor-Recipient Size Mismatch in Deceased Donor Liver Transplantation
Revisiting the Prognostic Influences of Donor-Recipient Size Mismatch in Deceased Donor Liver Transplantation Open
Background. Liver transplantation (LT) outcomes are influenced by donor-recipient size mismatch. This study re-evaluated the impact on graft size discrepancies on survival outcomes. Methods. Data from 53 389 adult LT recipients from the Un…
View article: Beyond 75: Graft Allocation and Organ Utility Implications in Liver Transplantation
Beyond 75: Graft Allocation and Organ Utility Implications in Liver Transplantation Open
Background. The global surge in aging has intensified debates on liver transplantation (LT) for candidates aged 75 y and older, given the prevalent donor scarcity. This study examined both the survival benefits and organ utility of LT for …
View article: ChatGPT<i>versus</i>Bing: a clinician assessment of the accuracy of AI platforms when responding to COPD questions
ChatGPT<i>versus</i>Bing: a clinician assessment of the accuracy of AI platforms when responding to COPD questions Open
COPD is a global respiratory challenge ranking third in morbidity and mortality, primarily caused by exposure to particulate matter, notably from tobacco smoke [1, 2]. The resulting inflammation and lung damage can lead to symptoms such as…
View article: Where is the perfect triangle in the liver allocation system?
Where is the perfect triangle in the liver allocation system? Open
Fair and equitable allocation of livers for transplantation should consider three components: patient urgency, organ utilisation, and survival benefit. In the UK, the liver allocation algorithm, introduced in March 2018, prioritises maximi…
View article: Impact of donor characteristics on hepatocellular carcinoma recurrence after liver transplantation
Impact of donor characteristics on hepatocellular carcinoma recurrence after liver transplantation Open
Journal Article Impact of donor characteristics on hepatocellular carcinoma recurrence after liver transplantation Get access Miho Akabane, Miho Akabane Division of Abdominal Transplant, Department of Surgery, Stanford University Medical C…
View article: Has the risk of liver re‐transplantation improved over the two decades?
Has the risk of liver re‐transplantation improved over the two decades? Open
Background Despite advancements in liver transplantation (LT) over the past two decades, liver re‐transplantation (re‐LT) presents challenges. This study aimed to assess improvements in re‐LT outcomes and contributing factors. Methods Data…
View article: Characterizing the risk of human leukocyte antigen-incompatible living donor kidney transplantation in older recipients
Characterizing the risk of human leukocyte antigen-incompatible living donor kidney transplantation in older recipients Open
Older compatible living donor kidney transplant (CLDKT) recipients have higher mortality and death-censored graft failure (DCGF) compared to younger recipients. These risks may be amplified in older incompatible living donor kidney transpl…
View article: Development of a portable device to quantify hepatic steatosis in potential donor livers
Development of a portable device to quantify hepatic steatosis in potential donor livers Open
An accurate estimation of liver fat content is necessary to predict how a donated liver will function after transplantation. Currently, a pathologist needs to be available at all hours of the day, even at remote hospitals, when an organ do…
View article: Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma: Analysis of the US Multicenter HCC Transplant Consortium
Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma: Analysis of the US Multicenter HCC Transplant Consortium Open
HCC recurrence following liver transplantation (LT) is highly morbid and occurs despite strict patient selection criteria. Individualized prediction of post-LT HCC recurrence risk remains an important need. Clinico-radiologic and pathologi…
View article: The impact of geographic location versus center practice on center volume in liver transplantation after the acuity circle policy
The impact of geographic location versus center practice on center volume in liver transplantation after the acuity circle policy Open
Background The allocation system for livers used the acuity circles (AC) beginning in 2020. In this study, we sought to evaluate the effect of the AC policy on center transplant volumes, from geographic and center practice perspectives. Me…
View article: Reevaluating Liver Donor Risk in the Era of Improved Hepatitis C Virus Treatment
Reevaluating Liver Donor Risk in the Era of Improved Hepatitis C Virus Treatment Open
This cohort study examines the risk of graft failure associated with donors with hepatitis C virus (HCV) infection before and after the introduction of direct-acting antiviral medications.
View article: Impact of Donor Liver Macrovesicular Steatosis on Deceased Donor Yield and Posttransplant Outcome
Impact of Donor Liver Macrovesicular Steatosis on Deceased Donor Yield and Posttransplant Outcome Open
Background. The Scientific Registry of Transplant Recipients (SRTR) had not traditionally considered biopsy results in risk-adjustment models, yet biopsy results may influence outcomes and thus decisions regarding organ acceptance. Methods…
View article: Potential Relationships Between NAFLD Fibrosis Score and Graft Status in Liver Transplant Patients
Potential Relationships Between NAFLD Fibrosis Score and Graft Status in Liver Transplant Patients Open
Non-alcoholic fatty liver disease is projected to be the most common cause of liver failure in the coming decade and is a very common reason for liver transplantation. One measure of its severity is the level of hepatic fibrosis, tradition…
View article: Availability of a Web and Smartphone Application to Stratify the Risk of of Early Allograft Failure Requiring Liver Retransplantation
Availability of a Web and Smartphone Application to Stratify the Risk of of Early Allograft Failure Requiring Liver Retransplantation Open
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View article: Predictors of Outcomes of Patients Referred to a Transplant Center for Urgent Liver Transplantation Evaluation
Predictors of Outcomes of Patients Referred to a Transplant Center for Urgent Liver Transplantation Evaluation Open
Liver transplantation (LT) is definitive treatment for end‐stage liver disease. This study evaluated factors predicting successful evaluation in patients transferred for urgent inpatient LT evaluation. Eighty‐two patients with cirrhosis we…
View article: Posttransplant Outcomes in Older Patients With Hepatocellular Carcinoma Are Driven by Non–Hepatocellular Carcinoma Factors
Posttransplant Outcomes in Older Patients With Hepatocellular Carcinoma Are Driven by Non–Hepatocellular Carcinoma Factors Open
The incidence of hepatocellular carcinoma (HCC) is growing in the United States, especially among the elderly. Older patients are increasingly receiving transplants as a result of HCC, but the impact of advancing age on long‐term posttrans…
View article: NuSeT: A deep learning tool for reliably separating and analyzing crowded cells
NuSeT: A deep learning tool for reliably separating and analyzing crowded cells Open
Segmenting cell nuclei within microscopy images is a ubiquitous task in biological research and clinical applications. Unfortunately, segmenting low-contrast overlapping objects that may be tightly packed is a major bottleneck in standard …
View article: Pulmonary Artery Migration of a Peripheral Endovascular Stent Discovered Prior to Renal Transplantation: A Case Report
Pulmonary Artery Migration of a Peripheral Endovascular Stent Discovered Prior to Renal Transplantation: A Case Report Open
Background: Arteriovenous fistulas and grafts are preferred access for hemodialysis. Outflow stenosis is a common complication that can be managed with angioplasty and stenting. Stent placement can be complicated by thrombosis, limited are…
View article: What solid organ transplant healthcare providers should know about renin‐angiotensin‐aldosterone system inhibitors and COVID‐19
What solid organ transplant healthcare providers should know about renin‐angiotensin‐aldosterone system inhibitors and COVID‐19 Open
The data on the outcomes of solid organ transplant recipients who have contracted coronavirus disease 2019 (COVID‐19) are still emerging. Kidney transplant recipients are commonly prescribed renin‐angiotensin‐aldosterone system (AAS) inhib…