Michael L. Merchant
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View article: Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function
Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function Open
Mitochondrial dysfunction contributes to various inflammatory‐related diseases by triggering the release of inflammatory molecules. Targeting mitochondrial dysfunction is emerging as a promising avenue for treating inflammatory diseases. H…
View article: Acute and Persistent Cardiovascular Effects of Menthol E‐Cigarettes in Mice
Acute and Persistent Cardiovascular Effects of Menthol E‐Cigarettes in Mice Open
Background Although e‐cigarettes provide an alternative to conventional smoking, the cardiovascular impacts of e‐cigarette use are unresolved. The popularity of menthol e‐cigarettes has surged recently and may escalate further with bans on…
View article: <i>Yersinia pestis</i> Actively Inhibits the Production of Extracellular Vesicles by Human Neutrophils
<i>Yersinia pestis</i> Actively Inhibits the Production of Extracellular Vesicles by Human Neutrophils Open
Yersinia pestis is the etiologic agent of the plague. A hallmark of plague is subversion of the host immune response by disrupting host signalling pathways required for inflammation. This non‐inflammatory environment permits bacterial colo…
View article: Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen
Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen Open
Endogenous pathogens can constrain virulence to ensure survival in the host. Pathogenic state can be controlled by metabolic responses to the prevailing microenvironment; however, the coupling and effector mechanisms are not well understoo…
View article: Preclinical Long-Term Stability and Forced Degradation Assessment of EPICERTIN, a Mucosal Healing Biotherapeutic for Inflammatory Bowel Disease
Preclinical Long-Term Stability and Forced Degradation Assessment of EPICERTIN, a Mucosal Healing Biotherapeutic for Inflammatory Bowel Disease Open
Background/Objectives: EPICERTIN, a biotherapeutic candidate for mucosal healing in inflammatory bowel disease (IBD) and other mucosal disorders, was subjected to an extensive long-term stability program to evaluate its molecular stability…
View article: Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites
Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites Open
Diet has emerged as a key impact factor for gut microbiota function. However, the complexity of dietary components makes it difficult to predict specific outcomes. Here we investigate the impact of plant-derived nanoparticles (PNP) on gut …
View article: CXCL12 ameliorates neutrophilia and disease severity in SARS-CoV-2 infection
CXCL12 ameliorates neutrophilia and disease severity in SARS-CoV-2 infection Open
Neutrophils, particularly low-density neutrophils (LDNs), are believed to contribute to acute COVID-19 severity. Here, we showed that neutrophilia can be detected acutely and even months after SARS-CoV-2 infection in patients and mice, whi…
View article: <i>Yersinia pestis</i>actively inhibits the production of extracellular vesicles by human neutrophils
<i>Yersinia pestis</i>actively inhibits the production of extracellular vesicles by human neutrophils Open
Yersinia pestis is the etiologic agent of the plague. A hallmark of plague is subversion of the host immune response by disrupting host signaling pathways required for inflammation. This non-inflammatory environment permits bacterial colon…
View article: Hepatic Proteomic Changes Associated with Liver Injury Caused by Alcohol Consumption in Fpr2−/− Mice
Hepatic Proteomic Changes Associated with Liver Injury Caused by Alcohol Consumption in Fpr2−/− Mice Open
Alcohol-associated liver disease (ALD) is a prevalent medical problem with limited effective treatment strategies. Although many biological processes contributing to ALD have been elucidated, a complete understanding of the underlying mech…
View article: A plasma peptidomic signature reveals extracellular matrix remodeling and predicts prognosis in alcohol-associated hepatitis
A plasma peptidomic signature reveals extracellular matrix remodeling and predicts prognosis in alcohol-associated hepatitis Open
Background: Alcohol-associated hepatitis (AH) is plagued with high mortality and difficulty in identifying at-risk patients. The extracellular matrix undergoes significant remodeling during inflammatory liver injury and could potentially b…
View article: Ileum Proteomics Identifies Distinct Pathways Associated with Different Dietary Doses of Copper–Fructose Interactions: Implications for the Gut–Liver Axis and MASLD
Ileum Proteomics Identifies Distinct Pathways Associated with Different Dietary Doses of Copper–Fructose Interactions: Implications for the Gut–Liver Axis and MASLD Open
The interactions of different dietary doses of copper with fructose contribute to the development of metabolic dysfunction-associated steatotic liver disease (MASLD) via the gut–liver axis. The underlying mechanisms remain elusive. The aim…
View article: Multiomics Analysis of PCB126’s Effect on a Mouse Chronic-Binge Alcohol Feeding Model
Multiomics Analysis of PCB126’s Effect on a Mouse Chronic-Binge Alcohol Feeding Model Open
Previous work has demonstrated that PCB126 is a modifying factor in metabolic dysfunction-associated steatotic liver disease (MASLD), and our current work suggests that pollutants also modify ALD. PCB126 may, in part, be contributing to th…
View article: Abstract 1487 Fpr2-/- mice fed alcohol had reduced hepatic expression of coagulation factors and antioxidants, as identified by proteomic analysis
Abstract 1487 Fpr2-/- mice fed alcohol had reduced hepatic expression of coagulation factors and antioxidants, as identified by proteomic analysis Open
Alcohol-associated liver disease (ALD) is a global healthcare problem with limited treatment options. Recently, Fpr2-/- (formyl peptide receptor 2 knockout) mice were shown to develop exacerbated alcohol-induced liver injury and inflammati…
View article: Outer Membrane Vesicles Released from Garlic Exosome‐like Nanoparticles (GaELNs) Train Gut Bacteria that Reverses Type 2 Diabetes via the Gut‐Brain Axis
Outer Membrane Vesicles Released from Garlic Exosome‐like Nanoparticles (GaELNs) Train Gut Bacteria that Reverses Type 2 Diabetes via the Gut‐Brain Axis Open
Gut microbiota function has numerous effects on humans and the diet humans consume has emerged as a pivotal determinant of gut microbiota function. Here, a new concept that gut microbiota can be trained by diet‐derived exosome‐like nanopar…
View article: Site-Specific Identification of Protein S-Acylation by IodoTMT0 Labeling and Immobilized Anti-TMT Antibody Resin Enrichment
Site-Specific Identification of Protein S-Acylation by IodoTMT0 Labeling and Immobilized Anti-TMT Antibody Resin Enrichment Open
Protein S-acylation is a reversible post-translational modification (PTM). It is present on diverse proteins and has important roles in regulating protein function. Aminolysis with hydroxylamine is widely used in the global identification …
View article: A plasma peptidomic signature reveals extracellular matrix remodeling and predicts prognosis in alcohol-related hepatitis
A plasma peptidomic signature reveals extracellular matrix remodeling and predicts prognosis in alcohol-related hepatitis Open
Alcohol-related hepatitis (AH) is plagued with high mortality and difficulty in identifying at-risk patients. The extracellular matrix undergoes significant remodeling during inflammatory liver injury that can be detected in biological flu…
View article: Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration
Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration Open
Activation and transdifferentiation of hepatic stellate cells (HSC) into migratory myofibroblasts is a key process in liver fibrogenesis. Cell migration requires an active remodeling of the cytoskeleton, which is a tightly regulated proces…
View article: Identification of small extracellular vesicle protein biomarkers for pediatric Ewing Sarcoma
Identification of small extracellular vesicle protein biomarkers for pediatric Ewing Sarcoma Open
Ewing Sarcoma (EWS) is the second most common osseous malignancy in children and young adults after osteosarcoma, while it is the fifth common osseous malignancy within adult age population. The clinical presentation of EWS is quite often …
View article: MK2 nonenzymatically promotes nuclear translocation of caspase-3 and resultant apoptosis
MK2 nonenzymatically promotes nuclear translocation of caspase-3 and resultant apoptosis Open
We have previously identified mitogen-activated protein kinase-activated protein kinase 2 (MK2) is required for caspase-3 nuclear translocation in the execution of apoptosis; however, little is known of the underlying mechanisms. Therefore…
View article: Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a “Patient-Specific” Approach
Multiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a “Patient-Specific” Approach Open
These studies confirmed that a novel "patient-specific" bioinformatic approach can integrate disparate omics datasets and identify candidate SRNS biomarkers not observed by separate proteomic or metabolomic analysis.
View article: Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer
Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer Open
MK2, known to promote caspase-3 nuclear translocation in the execution of apoptosis, is reduced in non-small cell lung cancer cells. In adenocarcinomas of patients, higher MK2 expression is associated with early-stage disease, better clini…
View article: The plasma degradome reflects later development of NASH fibrosis after liver transplant
The plasma degradome reflects later development of NASH fibrosis after liver transplant Open
Although liver transplantation (LT) is an effective therapy for cirrhosis, the risk of post-LT NASH is alarmingly high and is associated with accelerated progression to fibrosis/cirrhosis, cardiovascular disease, and decreased survival. La…
View article: An extracellular vesicular mutant KRAS‐associated protein complex promotes lung inflammation and tumor growth
An extracellular vesicular mutant KRAS‐associated protein complex promotes lung inflammation and tumor growth Open
Extracellular vesicles (EVs) contain more than 100 proteins. Whether there are EVs proteins that act as an ‘organiser’ of protein networks to generate a new or different biological effect from that identified in EV‐producing cells has neve…
View article: Methods and kits for predicting a response to an erythropoietic agent
Methods and kits for predicting a response to an erythropoietic agent Open
Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID …
View article: Fibrosis resolution in the mouse liver: Role of Mmp12 and potential role of calpain 1/2
Fibrosis resolution in the mouse liver: Role of Mmp12 and potential role of calpain 1/2 Open
Although most work has focused on resolution of collagen ECM, fibrosis resolution involves changes to several ECM proteins. The purpose of the current study was twofold: 1) to examine the role of MMP12 and elastin; and 2) to investigate th…
View article: Dataset for proteomic analysis of arylamine N-acetyltransferase 1 knockout MDA-MB-231 breast cancer cells
Dataset for proteomic analysis of arylamine N-acetyltransferase 1 knockout MDA-MB-231 breast cancer cells Open
Arylamine N-acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer. An unbiased analysis of proteomes of parental MDA-MB-231 breast cancer cells and two separate NAT1 knockout (KO) cell lines were performed. Among 4,890 prot…