Michael E. Mitchell
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View article: Lipid nanoparticle co-delivery of mRNA and a small molecule drug for oral cancer chemoimmunotherapy
Lipid nanoparticle co-delivery of mRNA and a small molecule drug for oral cancer chemoimmunotherapy Open
Oral squamous cell carcinoma (OSCC) represents 90% of all head and neck cancers. Despite decades of research, the 5-year survival rate is 50%, and strikingly, the overall incidence rate is projected to increase by 30% in the next ten years…
View article: 0733 Insomnia Severity Predicts Increased PAP Side Effects and Use in Women Veterans with Newly Diagnosed Apnea
0733 Insomnia Severity Predicts Increased PAP Side Effects and Use in Women Veterans with Newly Diagnosed Apnea Open
Introduction Despite positive airway pressure (PAP) being the gold-standard treatment for sleep disordered breathing (SDB), treatment adherence remains a challenge for providers and patients. Women with SDB are understudied, and understand…
View article: MYH6 Variants Are Associated with Atrial Dysfunction in Neonates with Hypoplastic Left Heart Syndrome
MYH6 Variants Are Associated with Atrial Dysfunction in Neonates with Hypoplastic Left Heart Syndrome Open
Background: MYH6 variants are the most well-known genetic risk factor (10%) for hypoplastic left heart syndrome (HLHS) and are associated with decreased cardiac transplant-free survival. MYH6 encodes for α-myosin heavy chain (α-MHC), a con…
View article: Walking together in friendship: Learning about cultural safety in mainstream mental health services through Aboriginal Participatory Action Research
Walking together in friendship: Learning about cultural safety in mainstream mental health services through Aboriginal Participatory Action Research Open
Objective: Culturally safe service provision is essential to improving social and emotional wellbeing among Aboriginal and Torres Strait Islander communities, and to eliminating health inequities. Cultural safety is about ensuring that all…
View article: Evaluating threshold for donor fraction cell‐free <scp>DNA</scp> using clinically available assay for rejection in pediatric and adult heart transplantation
Evaluating threshold for donor fraction cell‐free <span>DNA</span> using clinically available assay for rejection in pediatric and adult heart transplantation Open
Background The aims of the study were to assess the performance of a clinically available cell‐free DNA (cfDNA) assay in a large cohort of pediatric and adult heart transplant recipients and to evaluate performance at specific cut points i…
View article: Evaluating a social and emotional well-being model of service piloted in Aboriginal Community Controlled Health Services in Western Australia: an Aboriginal Participatory Action Research approach
Evaluating a social and emotional well-being model of service piloted in Aboriginal Community Controlled Health Services in Western Australia: an Aboriginal Participatory Action Research approach Open
Introduction The delivery of services to improve Aboriginal health and well-being must centre culture and integrate a social and emotional well-being understanding and approaches. These approaches are essential in increasing access to, and…
View article: 3D-bioprinting of patient-derived cardiac tissue models for studying congenital heart disease
3D-bioprinting of patient-derived cardiac tissue models for studying congenital heart disease Open
Introduction Congenital heart disease is the leading cause of death related to birth defects and affects 1 out of every 100 live births. Induced pluripotent stem cell technology has allowed for patient-derived cardiomyocytes to be studied …
View article: Altered contractility, Ca<sup>2+</sup> transients, and cell morphology seen in a patient-specific iPSC-CM model of Ebstein’s anomaly with left ventricular noncompaction
Altered contractility, Ca<sup>2+</sup> transients, and cell morphology seen in a patient-specific iPSC-CM model of Ebstein’s anomaly with left ventricular noncompaction Open
We demonstrate here that iPSCs derived from patients with Ebstein’s anomaly and left ventricular noncompaction, when differentiated into cardiomyocytes, display significant structural and functional changes that offer insight into disease …
View article: 0469 Efficacy of In-Person vs Telehealth Positive Airway Set-Up in Veterans
0469 Efficacy of In-Person vs Telehealth Positive Airway Set-Up in Veterans Open
Introduction The SARS-CoV-2 pandemic necessitated a transition to sleep telehealth, including for positive airway pressure (PAP) set up. Prior to this change, the standard of care for initiation of PAP therapy included a face-to-face visit…
View article: 0927 The Evolution of Costs for Telehealth versus In-person PAP Initiation for Patients with Sleep Apnea over the COVID Pandemic
0927 The Evolution of Costs for Telehealth versus In-person PAP Initiation for Patients with Sleep Apnea over the COVID Pandemic Open
Introduction During the COVID pandemic, at the San Francisco VA Healthcare System (VASFHS), positive airway pressure (PAP) set-up visits transitioned from in person to a mix of in person and telehealth for patients newly diagnosed sleep ap…
View article: Co‐designing research with Aboriginal and Torres Strait Islander consumers of mental health services, mental health workers, elders and cultural healers
Co‐designing research with Aboriginal and Torres Strait Islander consumers of mental health services, mental health workers, elders and cultural healers Open
Introduction The disparity in mental health outcomes compared with non‐Indigenous Australians means that there is an urgent need to develop an evidence base around how services can better support Aboriginal and Torres Strait Islander commu…
View article: Sclerosing Pneumocytoma With Pulmonary Sarcoidosis: A Case Report
Sclerosing Pneumocytoma With Pulmonary Sarcoidosis: A Case Report Open
Pulmonary sclerosing pneumocytoma, formally named pulmonary sclerosing hemangioma, is a rare benign tumor with malignant potential often identified as solid pulmonary nodules. Sarcoidosis is an inflammatory, multisystemic disease of unknow…
View article: Rings and Slings: Not Such Simple Things
Rings and Slings: Not Such Simple Things Open
Purpose of Review Vascular rings are congenital malformations resulting from abnormal development of the great vessels, with the consequent encircling and compression of the trachea, esophagus, or both. We conducted a review of the current…
View article: 0362 The Cost of In-Person versus Telehealth PAP Initiation for Patients with Sleep Apnea
0362 The Cost of In-Person versus Telehealth PAP Initiation for Patients with Sleep Apnea Open
Introduction Telehealth has been widely integrated into healthcare systems during the COVID-19 pandemic and is likely to remain a part of routine clinical care. At the VA Greater Los Angeles Healthcare System (VAGLAHS), positive airway pre…
View article: Significance of α-Myosin Heavy Chain (MYH6) Variants in Hypoplastic Left Heart Syndrome and Related Cardiovascular Diseases
Significance of α-Myosin Heavy Chain (MYH6) Variants in Hypoplastic Left Heart Syndrome and Related Cardiovascular Diseases Open
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with complex genetic inheritance. HLHS segregates with other left ventricular outflow tract (LVOT) malformations in families, and can present as either an is…
View article: A Systematic Review of Ebstein’s Anomaly with Left Ventricular Noncompaction
A Systematic Review of Ebstein’s Anomaly with Left Ventricular Noncompaction Open
Traditional definitions of Ebstein’s anomaly (EA) and left ventricular noncompaction (LVNC), two rare congenital heart defects (CHDs), confine disease to either the right or left heart, respectively. Around 15–29% of patients with EA, whic…
View article: 371 Decreased Contraction Rate, Altered Calcium Transients, and Increased Proliferation seen in Patient-specific iPSC-CMs Modeling Ebsteins Anomaly and Left Ventricular Noncompaction
371 Decreased Contraction Rate, Altered Calcium Transients, and Increased Proliferation seen in Patient-specific iPSC-CMs Modeling Ebsteins Anomaly and Left Ventricular Noncompaction Open
OBJECTIVES/GOALS: In a familial case where 10 of 17 members inherited EA/LVNC in an autosomal dominant pattern, we discovered a novel, damaging missense variant in the gene KLHL26 that segregates with disease and comprises an altered elect…
View article: Children’s Data Network
Children’s Data Network Open
The Children's Data Network (CDN) is a data and research collaborative focused on the linkage and analysis of administrative records. In partnership with public agencies, philanthropic funders, affiliated researchers, and community stakeho…
View article: Pulmonary Vein Stenosis: Moving From Past Pessimism to Future Optimism
Pulmonary Vein Stenosis: Moving From Past Pessimism to Future Optimism Open
Pulmonary Vein Stenosis (PVS) is a rare disease with a prevalence of around 1. 7 cases per 100,000 children under 2 years old. Treatment options for this disease have not provided great results and pathophysiology of this condition is stil…
View article: Correction: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease
Correction: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease Open
[This corrects the article DOI: 10.1371/journal.pgen.1009679.].
View article: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease
Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease Open
Numerous genetic studies have established a role for rare genomic variants in Congenital Heart Disease (CHD) at the copy number variation (CNV) and de novo variant (DNV) level. To identify novel haploinsufficient CHD disease genes, we perf…
View article: 77085 Impact of MYH6 Variants on Development and Clinical Course of Hypoplastic Left Heart Syndrome
77085 Impact of MYH6 Variants on Development and Clinical Course of Hypoplastic Left Heart Syndrome Open
IMPACT: This work represents a novel way in which genetic information can be used to improve clinical decision making as it pertains to both treatment and management of congenital heart disease. OBJECTIVES/GOALS: Our lab found that MYH6 va…