Michaël Molinari
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View article: N-formylation modifies membrane damage associated to PSMα3 interfacial fibrillation
N-formylation modifies membrane damage associated to PSMα3 interfacial fibrillation Open
The virulence of Staphylococcus aureus, a multi-drug resistant pathogen, notably depends on the expression of the phenol soluble modulins α3 (PSMα3) peptides, able to self-assemble into amyloid-like cross-α fibrils. Despite remarkable adva…
View article: N-Formylation modifies membrane damage associated with PSMα3 interfacial fibrillation
N-Formylation modifies membrane damage associated with PSMα3 interfacial fibrillation Open
N-Formylation and oligomeric entities, formed along amyloid fibrillation, are critical for PSMα3 to induce lipid-dependent membrane damage.
View article: Interaction of full-length Tau with negatively charged lipid membranes leads to polymorphic aggregates
Interaction of full-length Tau with negatively charged lipid membranes leads to polymorphic aggregates Open
The Tau protein strongly binds to phosphatidylserine membranes, with partial membrane disruption and formation of polymorphic aggregates.
View article: Bioactive hydrogels based on lysine dendrigrafts as crosslinkers: tailoring elastic properties to influence hMSC osteogenic differentiation
Bioactive hydrogels based on lysine dendrigrafts as crosslinkers: tailoring elastic properties to influence hMSC osteogenic differentiation Open
Optimizing hydrogels for tissue engineering with multivalent crosslinking lysine dendrigrafts.
View article: Influence of Surface Chemistry of Fiber and Lignocellulosic Materials on Adhesion Properties with Polybutylene Succinate at Nanoscale
Influence of Surface Chemistry of Fiber and Lignocellulosic Materials on Adhesion Properties with Polybutylene Succinate at Nanoscale Open
The production of bio-based composites with enhanced characteristics constitutes a strategic action to minimize the use of fossil fuel resources. The mechanical performances of these materials are related to the specific properties of thei…
View article: Dynamized ultra-low dilution of <i>Ruta graveolens</i> disrupts plasma membrane organization and decreases migration of melanoma cancer cell
Dynamized ultra-low dilution of <i>Ruta graveolens</i> disrupts plasma membrane organization and decreases migration of melanoma cancer cell Open
Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology.…
View article: Synthesis and Characterization of Conjugated Hyaluronic Acids. Application to Stability Studies of Chitosan-Hyaluronic Acid Nanogels Based on Fluorescence Resonance Energy Transfer
Synthesis and Characterization of Conjugated Hyaluronic Acids. Application to Stability Studies of Chitosan-Hyaluronic Acid Nanogels Based on Fluorescence Resonance Energy Transfer Open
Hyaluronic acid (HA) was functionalized with a series of amino synthons (octylamine, polyethylene glycol amine, trifluoropropyl amine, rhodamine). Sodium hyaluronate (HAs) was first converted into its protonated form (HAp) and the reaction…
View article: Actin Bundle Nanomechanics and Organization Are Modulated by Macromolecular Crowding and Electrostatic Interactions
Actin Bundle Nanomechanics and Organization Are Modulated by Macromolecular Crowding and Electrostatic Interactions Open
The structural and mechanical properties of actin bundles are essential to eukaryotic cells, aiding in cell motility and mechanical support of the plasma membrane. Bundle formation occurs in crowded intracellular environments composed of v…
View article: Carbamylation of elastic fibers is a molecular substratum of aortic stiffness
Carbamylation of elastic fibers is a molecular substratum of aortic stiffness Open
Because of their long lifespan, matrix proteins of the vascular wall, such as elastin, are subjected to molecular aging characterized by non-enzymatic post-translational modifications, like carbamylation which results from the binding of c…
View article: Fluorescent chitosan-based nanohydrogels and encapsulation of gadolinium MRI contrast agent for magneto-optical imaging
Fluorescent chitosan-based nanohydrogels and encapsulation of gadolinium MRI contrast agent for magneto-optical imaging Open
International audience
View article: Pyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies
Pyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies Open
International audience
View article: Interaction of Tau construct K18 with model lipid membranes
Interaction of Tau construct K18 with model lipid membranes Open
AFM imaging of model membranes of controlled composition in interaction with Tau construct K18 showed PIP2 induced K18 fibrillization.
View article: Revealing the elasticity of an individual aortic fiber during ageing at nanoscale by<i>in situ</i>atomic force microscopy
Revealing the elasticity of an individual aortic fiber during ageing at nanoscale by<i>in situ</i>atomic force microscopy Open
Atomic Force Microscopy imaging allows to correlate at high resolution local changes in the structure and the elastic properties of elastin fibers and of the surrounding matrix for mice aorta cross sections.
View article: Growth of Homogeneous Luminescent Silicon–Terbium Nanowires by One-Step Electrodeposition in Ionic Liquids
Growth of Homogeneous Luminescent Silicon–Terbium Nanowires by One-Step Electrodeposition in Ionic Liquids Open
An electrodeposition method for the growth of homogeneous silicon–terbium nanowires (NWs) with green light emission is described. The method involves template-assisted electrochemical co-deposition of Si/Tb NWs with 90-nm diameter from an …
View article: High Speed AFM and NanoInfrared Spectroscopy Investigation of Aβ1–42 Peptide Variants and Their Interaction With POPC/SM/Chol/GM1 Model Membranes
High Speed AFM and NanoInfrared Spectroscopy Investigation of Aβ1–42 Peptide Variants and Their Interaction With POPC/SM/Chol/GM1 Model Membranes Open
Due to an aging population, neurodegenerative diseases such as Alzheimer's disease (AD) have become a major health issue. In the case of AD, Aβ1 - 42 peptides have been identified as one of the markers of the disease with the formation of …
View article: Dual Antioxidant Properties and Organic Radical Stabilization in Cellulose Nanocomposite Films Functionalized by In Situ Polymerization of Coniferyl Alcohol
Dual Antioxidant Properties and Organic Radical Stabilization in Cellulose Nanocomposite Films Functionalized by In Situ Polymerization of Coniferyl Alcohol Open
A new biobased material based on an original strategy using lignin model compounds as natural grafting additive on a nanocellulose surface through in situ polymerization of coniferyl alcohol by the Fenton reaction at two pH values was inve…
View article: Nanoindentation study of the mechanical properties and deformation behavior of nanoporous alumina films
Nanoindentation study of the mechanical properties and deformation behavior of nanoporous alumina films Open
Over the past decade, anodic aluminium oxide (AAO) has become one of the most widely used materials as a platform for developing new types of devices in micro- and nanotechnology. Due to the potential use of highly ordered honeycomb porous…
View article: Raman and AFM-IR chemical imaging of stratum corneum model membranes
Raman and AFM-IR chemical imaging of stratum corneum model membranes Open
Stratum corneum (SC), the outermost layer of the epidermis, is the primary barrier to percutaneous absorption. The diffusion of substances through the skin occurs through the SC lipid fraction, which is essentially constituted of an equimo…
View article: High speed atomic force microscopy to investigate the interactions between toxic Aβ1-42 peptides and model membranes in real time: impact of the membrane composition
High speed atomic force microscopy to investigate the interactions between toxic Aβ1-42 peptides and model membranes in real time: impact of the membrane composition Open
Due to an aging population, neurodegenerative diseases have become a major health issue, the most common being Alzheimer’s disease. The mechanisms leading to neuronal loss still remain unclear but recent studies suggest that soluble Aβ oli…
View article: Flexible plasmonic and strain sensors: fabrication, design and perspectives
Flexible plasmonic and strain sensors: fabrication, design and perspectives Open
In this paper, we aim at debating the perspectives for plasmonic strain sensors which have attracted interest for the past five years. In particular, we strive to discuss the choice of strategy to increase the sensitivity, either by develo…
View article: Using AlN Coatings to Protect the Surface of AlGaAs/GaAs System Heterostructures from Interaction with Atmospheric Oxygen
Using AlN Coatings to Protect the Surface of AlGaAs/GaAs System Heterostructures from Interaction with Atmospheric Oxygen Open
International audience
View article: Применение покрытий AlN для защиты поверхности гетероструктур системы AlGaAs/GaAs от взаимодействия с атмосферным кислородом
Применение покрытий AlN для защиты поверхности гетероструктур системы AlGaAs/GaAs от взаимодействия с атмосферным кислородом Open
The paper presents the results of the synthesis of thin aluminum nitride films by reactive ion-plasma sputtering and the study of their properties with the aim of using as the protective coatings for the high-power AlxGa1-xAs/GaAs semicond…
View article: Influence of the polarity of the matrix on the breakage mechanisms of lignocellulosic fibers during twin‐screw extrusion
Influence of the polarity of the matrix on the breakage mechanisms of lignocellulosic fibers during twin‐screw extrusion Open
In a series of previous papers, models describing the breakage of lignocellulose fibers during melt mixing process were established and applied to predict fiber size changes when compounding composites in a twin‐screw extruder. Different t…