Moshe Levi
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View article: Characterization of the Ocular Phenotype in a <i>Col4a3</i> Knockout Mouse Model of Alport Syndrome
Characterization of the Ocular Phenotype in a <i>Col4a3</i> Knockout Mouse Model of Alport Syndrome Open
Col4a3 KO mice exhibited a differential inflammatory and profibrotic response in the cornea, retina, and lens, which may play a role in the ocular pathology of AS.
View article: Heart Failure: An Underappreciated Complication of Diabetes. A Consensus Report of the American Diabetes Association
Heart Failure: An Underappreciated Complication of Diabetes. A Consensus Report of the American Diabetes Association Open
Traditionally, the prevention and management of chronic complications in individuals with type 1 (T1D) and type 2 diabetes (T2D) has been focused on of nephropathy, retinopathy, neuropathy, and atherosclerotic cardiovascular disease (inc…
View article: Heart Failure: An Underappreciated Complication of Diabetes. A Consensus Report of the American Diabetes Association
Heart Failure: An Underappreciated Complication of Diabetes. A Consensus Report of the American Diabetes Association Open
Traditionally, the prevention and management of chronic complications in individuals with type 1 (T1D) and type 2 diabetes (T2D) has been focused on of nephropathy, retinopathy, neuropathy, and atherosclerotic cardiovascular disease (inc…
View article: Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers
Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers Open
As shown earlier, raft-like domains resembling those thought to be present in natural cell membranes can be formed in supported planar lipid monolayers. These liquid-ordered domains coexist with a liquid-disordered phase and form in monola…
View article: Spaceflight Activates Lipotoxic Pathways in Mouse Liver
Spaceflight Activates Lipotoxic Pathways in Mouse Liver Open
Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations in liver metabolism, particularly with respect to lipids, remain largely unexpl…
View article: Identification and expression analysis of type II and type III P<sub>i</sub> transporters in the opossum kidney cell line
Identification and expression analysis of type II and type III P<sub>i</sub> transporters in the opossum kidney cell line Open
New Findings What is the central question of this study? The opossum kidney (OK) cell line is the main in vitro model of proximal tubular P i transport, but it is incomplete because only the NaPiIIa P i transporter has been identified. Wha…
View article: FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity
FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity Open
Bile acids are ligands for the nuclear hormone receptor farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5. We have shown that FXR and TGR5 have renoprotective roles in diabetes- and obesity-related kidney disease. Here, we…
View article: The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor
The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor Open
Diabetic retinopathy (DR) is a complication secondary to diabetes and is the number one cause of blindness among working age individuals worldwide. Despite recent therapeutic breakthroughs using pharmacotherapy, a cure for DR has yet to be…
View article: Intestinal phosphate absorption is mediated by multiple transport systems in rats
Intestinal phosphate absorption is mediated by multiple transport systems in rats Open
Apical inorganic phosphate (P i ) transport in the small intestine seems to be mainly mediated by the sodium/P i cotransporter NaPi2b. To verify this role, we have studied the combined effects of pH, phosphonoformate, and P i deprivation o…
View article: Aliskiren increases aquaporin-2 expression and attenuates lithium-induced nephrogenic diabetes insipidus
Aliskiren increases aquaporin-2 expression and attenuates lithium-induced nephrogenic diabetes insipidus Open
The direct renin inhibitor aliskiren has been shown to be retained and persist in medullary collecting ducts even after treatment is discontinued, suggesting a new mechanism of action for this drug. The purpose of the present study was to …